Delving into the Latest Updates on Glyminox with Synapse

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

Glyminox gel, SAVVY

+ [2]

Target

Membrane lipids

Mechanism

Membrane lipids inhibitors

Therapeutic Areas

Immune System DiseasesInfectious DiseasesUrogenital Diseases

Active Indication-

Inactive Indication

HIV Infections

Originator Organization

Biosyn, Inc.

Active Organization-

Inactive Organization

Biosyn, Inc.

Drug Highest PhasePendingPhase 3

First Approval Date-

Regulation-

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Structure

Molecular FormulaC36H74N2O4

InChIKeyKALYGJOYPFFBRF-UHFFFAOYSA-N

CAS Registry664323-11-9

Aim: This study compared the effectiveness of three different mouthrinses (alcohol and non-alcohol chlorhexidine, alkyl dimethyl glycine / alkyl dimethyl amine oxide - C31G) in plaque control and early wound healing, postoperatively.
Materials and Methods: In this, randomized, double-blind, controlled clinical trial 42 patients were allocated to three groups assigned to two weeks rinsing after periodontal surgery with C31G (group A), alcohol-free chlorhexidine 0.12% (group B) or alcohol-based chlorhexidine 0.12% (group C). At weeks 1 and 2, plaque and early wound healing indices were recorded. At day 14, total bacterial counts were estimated utilizing real - time qPCR. Statistics included linear and generalized linear mixed models.

Start Date01 Nov 2015

Sponsor / Collaborator

National & Kapodistrian University of Athens

NCT00130078 / Unknown statusPhase 3

Randomized Controlled Trial of SAVVY and HIV in Nigeria

Heterosexual contact is now the primary route of transmission for HIV worldwide. This study is a phase 3 trial designed to determine the effectiveness and safety of the 1.0% C31G (SAVVY) vaginal gel for the prevention of male-to-female transmission of HIV among women at high risk.

Start Date01 Sep 2004

Sponsor / Collaborator

biosyn Corp.

[+1]

NCT00274261 / CompletedPhase 3

A Phase II/III Multicenter, Randomized, Double-masked, Study of the Safety and Contraceptive Efficacy of C31G Compared to Conceptrol®

This is a multicenter, randomized, double-masked, controlled, phase III study of repeated use of C31G vaginal gel compared to Conceptrol® Vaginal Gel as the primary method of contraception over six months (183 days) and at least six cycles of use. In addition, there is an opportunity for subjects to continue with study treatment for up to twelve months (365 days) and twelve cycles of treatment upon completion of the first six months of treatment.

Start Date01 Jun 2004

Sponsor / Collaborator

Health Decisions, Inc.

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100 Clinical Results associated with Glyminox

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100 Translational Medicine associated with Glyminox

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100 Patents (Medical) associated with Glyminox

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42

Literatures (Medical) associated with Glyminox

01 Sep 2018·Clinical Oral InvestigationsQ2 · MEDICINE

A randomized controlled clinical trial on the effectiveness of three different mouthrinses (chlorhexidine with or without alcohol and C31G), adjunct to periodontal surgery, in early wound healing

Q2 · MEDICINE

Article

Author: Kaminari, Archontia ; Vassilopoulos, Spyridon I ; Vrotsos, Ioannis A ; Gkatzonis, Anastasios M ; Karoussis, Ioannis K ; Madianos, Phoebus N

OBJECTIVESThe use of chlorhexidine (CHX) with or without alcohol has been recommended for a number of clinical applications. On the other hand, there is a plethora of widely subscribed antiseptics, such as agent C31G (alkyl dimethyl glycine/alkyl dimethyl amine oxide), which has not yet been evaluated postsurgically. The effectiveness of three different mouthrinses (CHX with and without alcohol, C31G) in plaque control and early wound healing was compared postoperatively.MATERIALS AND METHODSIn this, randomized, double-blind, controlled clinical trial 42 patients were allocated to three groups assigned to 2 weeks rinsing after non-regenerative periodontal flap surgery with or without osseous surgery with C31G (group A), alcohol-free CHX 0.12% (group B) or alcohol-based CHX 0.12% (group C). At days 7 and 14, plaque and early wound healing indices were recorded. At day 14, total bacterial counts were estimated utilizing real-time quantitative polymerase chain reaction (qPCR). Statistics included linear and generalized linear mixed models.RESULTSAt day 7, healing response was not significantly different among groups. At day 14, group A revealed the highest while group C demonstrated the lowest plaque index values (B vs A, odds ratio-OR = 0.18, p = 0.012; C vs A, OR = 0.01, p < 0.001; C vs B, OR = 0.06, p < 0.001). Group C demonstrated the lowest bacterial counts levels at day 14 (38.470 × 10⁶, 48.190 × 10⁶, and 3.020 × 10⁶ for groups A, B, and C, respectively). At day 14, healing was significantly better in group C compared to B (p = 0.007). Group A showed no significant differences compared to other groups.CONCLUSIONS(1) The presence of alcohol may increase the effectiveness of CHX in early wound healing, (2) C31G might be an alternative solution prescribed during early postoperative period after non-regenerative periodontal flap surgery.CLINICAL RELEVANCEThe present study found that active agent C31G displayed no significant differences to CHX formulations regarding periodontal wound healing improvement and might be used alternatively after non-regenerative periodontal flap surgery. In addition, an alcohol based 0.12% CHX mouthwash was more effective than an alcohol-free 0.12% CHX and C31G mouthrinse on plaque control in the absence of mechanical oral hygiene.

28 Jul 2014·Journal of Microbiology and BiotechnologyQ4 · ENGINEERING & TECHNOLOGY

In Vitro Virucidal Effect of Mouthrinse Containing C31G on Seasonal Influenza Viruses

Q4 · ENGINEERING & TECHNOLOGY

Article

Author: Lee, Dong-Hun ; Lee, Joong-Bok ; Kang, Jae-Hoon ; Choi, In-Soo ; Youn, Ha-Na ; Kang, Byung-Hwa ; Song, Chang-Seon ; Lee, Sang-Won ; Park, Jae-Keun ; Park, Seung-Yong

C31G is a potent antimicrobial agent and can disrupt the microbial membrane by the alkyl portion of the molecule. The objective of this study was to evaluate the virucidal effectiveness of C31G and mouthrinse containing C31G (Sense-Time) on seasonal influenza viruses. Evaluation of the virucidal activity against influenza viruses was performed with end-point titration in 10-day-old chicken embryos and Madin-Darby canine kidney cells. In vitro studies demonstrated that C31G and Sense-Time inhibited the growth of seasonal influenza viruses even in the presence of 5% organic material. Gargling with C31G or Sense-Time would enhance oropharyngeal hygiene, which would be helpful for reducing influenza transmission.

01 Oct 2013·Antiviral ResearchQ2 · MEDICINE

The antimicrobial agent C31G is effective for therapy for HSV-1 ocular keratitis in the rabbit eye model

Q2 · MEDICINE

Article

Author: Augusto C. Ochoa ; Christian Clement ; Harris E. McFerrin ; James M. Hill ; Timothy P. Foster ; Walter J. Lukiw ; Daniel Malamud ; Ethan M. Stern ; Paulo Rodriguez ; Cruz Velasco ; Partha S. Bhattacharjee

The amphoteric C31G solution contains equimolar alkyl dimethlyglycine and alkyl dimethyl amine oxide buffered with citric acid. C31G acts as a broad spectrum antiviral and an antibacterial. No previous in vivo studies have been done to test C31G in an animal model of HSV-1 ocular keratitis. We assessed the anti-herpetic activity of C31G in the rabbit eye model using three treatment groups: (1) 1% trifluorothymidine (TFT); (2) 0.25% C31G plus 0.5% hydroxypropyl methylcellulose (HPMC); and (3) vehicle, 0.5% HPMC. Scarified rabbit corneas were inoculated with the HSV-1 strain McKrae. On post inoculation (PI) day 3, rabbits were placed in three balanced groups based on slit-lamp examination (SLE) scores. Treatment began on PI day 3, five times a day for five consecutive days. In addition to the daily, masked SLE scoring, the eyes were assessed daily for stromal opacity, scleral inflammation, neovascularization, eyelid inflammation, inflammatory discharge, and epiphora. C31G and TFT were very effective in reducing the lesions and pathogenesis associated with HSV-1 ocular keratitis. The vehicle control scores were significantly higher and did not effectively treat HSV-1 keratitis. C31G has the potential to be used to treat herpetic keratitis as well as other herpetic topical lesions in humans.

100 Deals associated with Glyminox

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External Link

KEGG	Wiki	ATC	Drug Bank
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R&D Status

10 top R&D records.

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Indication	Highest Phase	Country/Location	Organization	Date
HIV Infections	Phase 3	GH	Biosyn, Inc.	01 Jan 2004

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Clinical Result

Indication

Phase

Evaluation

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


NCT00274261 (CTgov)	Phase 3	Pregnancy	1,565	C31G (C31G)	biokykleyr(shewvbqyht) = blryfuunad xrjithysca (xphutftmoy, spxvaolgec - fmgpwphitw) View more	-	06 Jun 2013
				Conceptrol (Conceptrol)	biokykleyr(shewvbqyht) = hegejzstfi xrjithysca (xphutftmoy, keypcnjjwl - xcqftajdui) View more
NCT00274261 (Pubmed \| Obstet Gynecol)	Phase 3	Pregnancy	1,565	C31G gel	(pttwgzfwqd) = yxaqivaija qetbxfkaps (mxlxetanfi, 9.3 - 14.7)	-	01 Dec 2010
				Nonoxynol-9 gel	(pttwgzfwqd) = zubtktjbxx qetbxfkaps (mxlxetanfi, 8.7 - 15.3)
NCT00130078 (Pubmed \| J Biol Chem)	Phase 3	HIV Infections	2,153	SAVVY	eunxdbgtiq(jyuasosfzj): hazard ratio = 1.7 (95% CI, 0.9 - 3.5), P-Value = 0.121	Negative	23 Jan 2008
				Placebo