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Last update 01 Nov 2025
DNV-3
Last update 01 Nov 2025
Overview
Basic Info
Drug Type Monoclonal antibody |
Synonyms DNV 3, DNV3 |
Target |
Action inhibitors, stimulants |
Mechanism LAG3 inhibitors(Lymphocyte activation gene 3 protein inhibitors), ADCC(Antibody-dependent cell-mediated cytotoxicity (ADCC) effects), T lymphocytes stimulants |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization- |
License Organization- |
Drug Highest PhasePhase 2 |
First Approval Date- |
Regulation- |
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Related
8
Clinical Trials associated with DNV-3CTR20243964
DNV3联合特瑞普利单抗联合化疗在经免疫检查点抑制剂治疗失败后的局部晚期不可切除/转移性黑色素瘤患者中有效性和安全性的单臂、开放、多中心、II期临床研究
[Translation] A single-arm, open-label, multicenter, phase II clinical study on the efficacy and safety of DNV3 combined with toripalimab and chemotherapy in patients with locally advanced unresectable/metastatic melanoma who have failed immune checkpoint inhibitor treatment
ChiCTR2400091269
An open-label, multicenter Phase 2 single-arm, study to assessing the efficacy and safety of DNV3 in combination with toripalimab and chemotherapy in patients with locally advanced unresectable or metastatic melanoma following failure of prior treatment with immune checkpoint inhibitors
ChiCTR2400079387
A single-arm, open-label clinical study of the first-line treatment with the combination of DNV3 and Toripalimab combined chemotherapy in patients with unresectable/metastatic mucosal melanoma, cutaneous squamous cell carcinoma and appendageal carcinomas
100 Clinical Results associated with DNV-3
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100 Translational Medicine associated with DNV-3
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100 Patents (Medical) associated with DNV-3
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100 Deals associated with DNV-3
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R&D Status
10 top R&D records. to view more data
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| Indication | Highest Phase | Country/Location | Organization | Date |
|---|---|---|---|---|
| Melanoma | Phase 2 | China | 04 Nov 2024 | |
| Esophageal Squamous Cell Carcinoma | Phase 2 | China | 27 Sep 2022 | |
| Gastrooesophageal junction cancer | Phase 2 | China | 27 Sep 2022 | |
| Liver Cancer | Phase 2 | China | 27 Sep 2022 | |
| Lymphoma | Phase 2 | China | 27 Sep 2022 | |
| Small Cell Lung Cancer | Phase 2 | China | 27 Sep 2022 | |
| squamous cell lung carcinoma | Phase 2 | China | 27 Sep 2022 | |
| Stomach Cancer | Phase 2 | China | 27 Sep 2022 | |
| Uterine Cervical Cancer | Phase 2 | China | 27 Sep 2022 | |
| Skin Neoplasms | Phase 2 | China | 20 Sep 2022 |
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Clinical Result
Clinical Result
Indication
Phase
Evaluation
View All Results
Not Applicable | 27 | tlvbjppfpe(zkzryxdcsg) = qvxdncjstj fdwzbftyeu (jzqsfonifm ) View more | Positive | 17 Oct 2025 | |||
(mucosal melanoma) | jdupyastkh(kyeohajggq) = fdmleiczon tzqbvfjzes (niusvlbrtd ) | ||||||
Early Phase 1 | Melanoma BRAF-mutant | PD-L1 | 27 | cbxzwjwgit(wblhzfllnp) = btchvgvqmp xgfuyjtgno (umzzuhxlzq, 19.4 - 57.6) | Positive | 30 May 2025 |
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