Author: Asghar, Muhammad Sohaib ; Khanzada, Shafqat Waqar ; Ahsan, Muhammad Nadeem ; Khalid, Faran ; Asif, Naila ; Fareed, Shameen ; Irshad, Syeda Ghazala ; Yasmin, Farah

BACKGROUND AND OBJECTIVESAnemia is a prevalent complication endured by patients with chronic renal disease. Renal anemia also leads to the development of cardio-vascular complications. Epoetin alpha and beta are recombinant human erythropoietin prioritized for managing anemia in hemodialysis patients. The current study aimed to compare the therapeutic efficacy of both erythropoietin alpha and erythropoietin beta in treating renal anemia.MATERIALS AND METHODSThis prospective observational study was conducted in a Renal Dialysis Centre at a tertiary care Hospital of Karachi, Pakistan for a period of 3 months. The two erythropoietin products used were human recombinant erythropoietin alpha (Tropin®) and erythropoietin beta (Recormon®). Both groups were age-matched, BMI, eGFR, gender, and comorbidities like diabetes and hypertension were indifferent. The comparative analysis was performed after the completion of 3 months.RESULTSA total of 94 participants were included in the analysis, 54 in group A and 40 in group B. Mean albumin, urea, creatinine, ferritin, iron, and transferrin saturation at inclusion were statistically insignificant, TIBC was higher in group A (p = 0.005) and CRP levels were slightly higher in group B (p = 0.050). There was significant improvement in Hb level (p = 0.025), PCV (p = 0.001), and RBC count (p = 0.007) in group B. While in group A, there was significantly increased MCV (p = 0.005) and MCHC (p = 0.002). In intention to treat analysis, 22.2% of subjects in group A and 40.0% in group B reached desired Hb levels of ≥11 g/l after 3 months.CONCLUSIONIn our assessment of hemodialysis patients, erythropoietin beta was found more effective than erythropoietin alpha.

01 Jan 2016·Journal of Pediatric Endocrinology and MetabolismQ4 · MEDICINE

Unusual phenotype of congenital adrenal hyperplasia (CAH) with a novel mutation of the CYP21A2 gene

Q4 · MEDICINE

Article

Author: Kluge, Michelle L. ; Prasad, Kris ; David, Raphael ; Shah, Bina ; Pappas, John G. ; Raisingani, Manish ; Contreras, Maria F.

AbstractGonadotropin independent sexual precocity (SP) may be due to congenital adrenal hyperplasia (CAH), and its timing usually depends on the type of mutation in the

03 Aug 1962·ScienceQ1 · CROSS-FIELD

On the Use of -tropin or -trophin in Connection with Anterior Pituitary Hormones

Q1 · CROSS-FIELD

Article

Author: Li, Choh Hao ; Stewart, Josephine

The divergent usage that has persisted in the literature in connection with the terminology of anterior pituitary hormones is discussed, and the reasons for proposing the acceptance of -tropins and tropic hormones for standard use are outlined.

100 Deals associated with Somatropin biosimilar (Daewoong Pharmaceutical Co., Ltd.)

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Indication	Country/Location	Organization	Date
Growth hormone deficiency	KR	Daewoong Pharmaceutical Co., Ltd.	05 Feb 2007

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