Synonyms GH receptor, GH-binding protein, GHBP + [7] |
Introduction Receptor for pituitary gland growth hormone (GH1) involved in regulating postnatal body growth (PubMed:1549776, PubMed:2825030, PubMed:8943276). On ligand binding, couples to the JAK2/STAT5 pathway (PubMed:1549776, PubMed:15690087, PubMed:2825030, PubMed:8943276).
The soluble form (GHBP) acts as a reservoir of growth hormone in plasma and may be a modulator/inhibitor of GH signaling.
Up-regulates the production of the soluble Growth hormone-binding protein form (GHBP) and acts as a negative inhibitor of growth hormone signaling. |
Target |
Mechanism GHR agonists |
Active Org. |
Originator Org. |
Inactive Indication- |
Drug Highest PhaseApproved |
First Approval Ctry. / Loc. Canada |
First Approval Date26 Oct 2021 |
Target |
Mechanism GHR agonists |
Active Org. |
Originator Org. |
Active Indication |
Inactive Indication |
Drug Highest PhaseApproved |
First Approval Ctry. / Loc. United States |
First Approval Date28 Aug 2020 |
Target |
Mechanism GHR agonists |
Active Org. |
Originator Org. |
Active Indication |
Inactive Indication- |
Drug Highest PhaseApproved |
First Approval Ctry. / Loc. China |
First Approval Date02 Dec 2015 |
Start Date01 Jun 2025 |
Sponsor / Collaborator [+2] |
Start Date01 Jun 2025 |
Sponsor / Collaborator Integrant Pty Ltd [+1] |
Start Date01 May 2025 |
Sponsor / Collaborator |