Last update 21 Nov 2024

APN-401

Overview

Basic Info

Drug Type
Gene therapy
Synonyms
siRNA-transfected PBMC APN401, siRNA-transfected peripheral blood mononuclear cells - Apeiron
+ [1]
Target
Mechanism
Cbl-b inhibitors(E3 ubiquitin-protein ligase CBL-B inhibitors)
Active Indication-
Originator Organization
Active Organization-
Drug Highest PhasePendingPhase 1
First Approval Date-
Regulation-
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Unresectable Solid NeoplasmPhase 2
US
28 Apr 2017
Colorectal CancerPhase 1
US
28 Apr 2017
Colorectal CancerPhase 1
US
28 Apr 2017
Pancreatic CarcinomaPhase 1
US
28 Apr 2017
Melanoma recurrentPhase 1
US
01 Dec 2014
Melanoma recurrentPhase 1
US
01 Dec 2014
Renal Cell CarcinomaPhase 1
US
01 Dec 2014
Renal Cell CarcinomaPhase 1
US
01 Dec 2014
Solid tumorPhase 1
US
14 Nov 2014
Unresectable Solid NeoplasmPreclinical
US
28 Apr 2017
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1
11
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-
10 Oct 2024
AACR2023
ManualManual
Phase 1
-
(skowqiqjli) = cdpmkqoopz xptmfohlgq (xomvviufwv )
Positive
14 Apr 2023
Phase 1
16
(gdqpijvilf) = mild chills, mild anemia, fatigue fsqcwhhjnw (asblbtmjnw )
Positive
04 Jun 2018
Phase 1
-
(zpzlawgjmq) = none ckjerbgcut (jkobfrepfk )
Positive
03 Jun 2016
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Clinical Trial

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Approval

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Regulation

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