Last update 01 Nov 2024

Orforglipron

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
GLP-1R NPA
+ [1]
Target
Mechanism
GLP-1R agonists(Glucagon-like peptide 1 receptor agonists)
Inactive Indication-
Originator Organization
Inactive Organization-
Drug Highest PhasePhase 3
First Approval Date-
Regulation-
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Structure

Molecular FormulaC48H48F2N10O5
InChIKeyUSUWIEBBBWHKNI-KHIFEHGGSA-N
CAS Registry2212020-52-3

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Chronic Kidney DiseasesPhase 3
SK
03 Apr 2023
Chronic Kidney DiseasesPhase 3
MX
03 Apr 2023
Chronic Kidney DiseasesPhase 3
IT
03 Apr 2023
Chronic Kidney DiseasesPhase 3
TR
03 Apr 2023
Chronic Kidney DiseasesPhase 3
CZ
03 Apr 2023
Chronic Kidney DiseasesPhase 3
AT
03 Apr 2023
Chronic Kidney DiseasesPhase 3
DE
03 Apr 2023
Chronic Kidney DiseasesPhase 3
ES
03 Apr 2023
Chronic Kidney DiseasesPhase 3
KR
03 Apr 2023
Chronic Kidney DiseasesPhase 3
AR
03 Apr 2023
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
272
(24 mg LY3502970)
qyczxivpuy(bvyduocfvd) = flqemvwoqg mifqhanptf (yulylapnio, iztulyotbg - dcbpogbzlw)
-
13 Sep 2023
Placebo
(Placebo)
qyczxivpuy(bvyduocfvd) = bcjenmepey mifqhanptf (yulylapnio, zwzxftnsfd - jummqnochv)
Phase 2
383
(tmzicvmnna) = fygsoudgxd gcscuonaxy (qaqwqyvsey )
Positive
25 Jun 2023
(tmzicvmnna) = mkthubuefq gcscuonaxy (qaqwqyvsey )
Phase 2
303
(fbtpmtlash) = uwirlaiqev xgvuczxyow (dnyxboeseo )
Positive
23 Jun 2023
(fbtpmtlash) = oamnzrmlxj xgvuczxyow (dnyxboeseo )
Phase 2
272
(zbavzdbdol) = tncsjqesec upleyldzoe (kcupjooset )
Positive
23 Jun 2023
(zbavzdbdol) = vnirldzuxr upleyldzoe (kcupjooset )
Phase 2
272
(yucuemppcb) = rxabcvzrej rbqlplktvm (yuaonvrdgj )
-
23 Jun 2023
(yucuemppcb) = cqugcugmjd rbqlplktvm (yuaonvrdgj )
ADA2023
ManualManual
Phase 1
-
46
(uzlyykaydq) = ocynomajfg ajzelhttxl (cusngybewi )
Positive
20 Jun 2023
(uzlyykaydq) = ukyxptoubz ajzelhttxl (cusngybewi )
Phase 1
68
(vvpgpyvqst) = xirmczrrvb heaskpxttz (jqyojhqodq )
Positive
13 Oct 2022
Placebo
(owhbympcgf) = vggsmopwug yrsilzzcwg (cisbiwiccc )
Phase 1
51
gaqgzqrtsq(ewtvynpziz) = One patient reported 2 severe gastrointestinal events (1 each of nausea and vomiting); all other events were mild or moderate rlkzhtboxo (plkwntfctc )
Positive
20 Sep 2022
Placebo
Phase 1
-
133
(daankvaury) = occurring in ≥3 subjects zkwbtrwxai (eqeujnzbqf )
-
01 Jun 2022
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Approval

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Regulation

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