Delving into the Latest Updates on SENL101 with Synapse

Overview

Basic Info

Drug Type

Autologous CAR-T

Synonyms

CD7-Specific CAR-T Cells(Hebei Senlangbio), DVHH NS7CAR-T(Hebei Senlangbio), KO7CAR

+ [5]

Target

CD7

Mechanism

CD7 inhibitors(T-cell antigen CD7 inhibitors)

Therapeutic Areas

NeoplasmsImmune System DiseasesHemic and Lymphatic Diseases+ [1]

Active Indication

T-cell Acute Lymphoblastic Leukemia/LymphomaPrecursor T-Cell Lymphoblastic Leukemia-LymphomaAdult Lymphoblastic Lymphoma+ [2]

Inactive Indication

CD7 Positive T-Cell LeukemiaNon-Hodgkin LymphomaRefractory T Acute Lymphoblastic Leukemia+ [1]

Originator Organization

Hebei Senlangbio Biotechnology Co., Ltd.

Active Organization

Hebei Senlangbio Biotechnology Co., Ltd.

Inactive Organization-

Drug Highest PhasePhase 1

First Approval Date-

RegulationOrphan Drug (US)

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主要研究目的：评价SENL101对于成人复发或难治性T淋巴母细胞淋巴瘤/白血病（T-LBL/ALL）患者的耐受性、安全性。次要研究目的：初步评价SENL101对于成人复发或难治性T淋巴母细胞淋巴瘤/白血病（T-LBL/ALL）患者治疗的有效性、药代动力学及药效动力学。

[Translation]

Primary study objective: To evaluate the tolerability and safety of SENL101 in adult patients with relapsed or refractory T-lymphoblastic lymphoma/leukemia (T-LBL/ALL). Secondary study objective: To preliminarily evaluate the efficacy, pharmacokinetics and pharmacodynamics of SENL101 in the treatment of adult patients with relapsed or refractory T-lymphoblastic lymphoma/leukemia (T-LBL/ALL).

Start Date04 Sep 2023

Sponsor / Collaborator

Hebei Senlangbio Biotechnology Co., Ltd.

NCT06136364

/ RecruitingPhase 1

Open-label, Dose-escalation Phase 1 Clinical Study of SENL101 Autologous T Cell Injection in the Treatment of Adult Patients With Relapsed or Refractory T-LBL/ALL

To evaluate the tolerability and safety of SENL101 in patients with relapsed or refractory T-LBL/ALL.

Start Date15 Aug 2023

Sponsor / Collaborator

Hebei Senlangbio Biotechnology Co., Ltd.

NCT05626400

/ RecruitingNot Applicable

Clinical Study of Senl-T7 CAR T Cells in the Treatment of Relapsed and Refractory CD7+ Acute T Lymphoblastic Leukemia and T Lymphoblastic Lymphoma

This is an open, prospective, dose-escalation clinical study to evaluate the safety and efficacy of Senl-T7 in patients with relapsed or refractory CD7+ acute T lymphoblastic leukemia or T lymphoblastic lymphoma.Meanwhile, PK/PD indexes of Senl-T7 were collected.

Start Date29 Aug 2022

Sponsor / Collaborator

Hebei Senlangbio Biotechnology Co., Ltd.

100 Clinical Results associated with SENL101

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100 Translational Medicine associated with SENL101

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100 Patents (Medical) associated with SENL101

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100 Deals associated with SENL101

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R&D Status

10 top R&D records.

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Indication	Highest Phase	Country/Location	Organization	Date
T-cell Acute Lymphoblastic Leukemia/Lymphoma	Phase 1	CN	Hebei Senlangbio Biotechnology Co., Ltd.	04 Sep 2023
T-Cell Lymphoma	Phase 1	CN	Hebei Senlangbio Biotechnology Co., Ltd.	01 May 2022
CD7 Positive T-Cell Leukemia	Phase 1	CN	Hebei Senlangbio Biotechnology Co., Ltd.	01 Oct 2020
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	Phase 1	CN	Hebei Senlangbio Biotechnology Co., Ltd.	01 Oct 2020
Refractory T Acute Lymphoblastic Leukemia	Phase 1	CN	Hebei Senlangbio Biotechnology Co., Ltd.	01 Oct 2020
Adult Lymphoblastic Lymphoma	Preclinical	US	Hebei Senlangbio Biotechnology Co., Ltd.	31 Aug 2023
Non-Hodgkin Lymphoma	Preclinical	CN	Hebei Senlangbio Biotechnology Co., Ltd.	12 Oct 2022

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Clinical Result

Indication

Phase

Evaluation

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


NCT04572308 \| NCT04916860 (ASH 12022 \| ASH 22022) Manual	Phase 1/2	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	53	Senl T7	htmtpcgruz(vprinmqgbs) = zubpysqtxz suqimuzkmo (hozcnljwli ) View more	Positive	15 Nov 2022
NCT04938115 \| NCT04916860 (EHA2022) Manual	Phase 1	T-cell lymphoma recurrent \| Refractory Hematologic Malignancy	15	KO7CAR T-cells+Fludarabine Phosphate+Cyclophosphamide	hyarcnwmkj(uuasuehdmq) = jrusymhjpz pztzutmgyf (wmvdqzhgtm ) View more	Positive	12 May 2022
NCT04572308 (Pubmed \| Circulation) Manual	Phase 1	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	20	Senl T7	ntepxvemym(zyotpdcyir) = 2pts neurotoxicity nwtkmxkmqd (xzckocvrno ) View more	Positive	02 May 2022
NCT04938115 (ASH 12021 \| ASH 22021) Manual	Phase 1	Mixed phenotype acute leukemia CD7 Positive	5	Senl T7	yaqgjyxhqa(wuamevzxyp) = vrhmrulavl noiqegmfnz (qehsvyupwq ) View more	Positive	05 Nov 2021