Last update 13 Dec 2025

OAP-189

Overview

Basic Info

Drug Type
Synthetic peptide
Synonyms
OAP 189, OAP189, PF-05212389
+ [2]
Target
GCGR x GLP-1R
Action
agonists
Mechanism
GCGR agonists(Glucagon receptor agonists), GLP-1R agonists(Glucagon-like peptide 1 receptor agonists)
Therapeutic Areas
Endocrinology and Metabolic Disease
Active Indication-
Inactive Indication
Diabetes Mellitus, Type 2Obesity
Originator Organization
Pfizer Inc.Pfizer Inc.
Active Organization-
Inactive Organization
Pfizer Inc.Pfizer Inc.
License Organization-
Drug Highest PhaseDiscontinuedPhase 1
First Approval Date-
Regulation-
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Related

2
Clinical Trials associated with OAP-189
NCT01472848
/ WithdrawnPhase 1
A Randomized, Double-Blind, Outpatient, Placebo-Controlled, Dose Titration Study Of Gastrointestinal Tolerability Of Pf 05212389 (Oap-189) In Obese Subjects
NCT00970593
/ CompletedPhase 1
A RANDOMIZED, PARALLEL-GROUP, OPEN-LABEL, PLACEBO CONTROLLED STUDY OF THE EFFECT OF OAP-189 ON THE PHARMACOKINETICS AND PHARMACODYNAMICS OF METFORMIN IN DIABETIC SUBJECTS.
100 Clinical Results associated with OAP-189
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100 Translational Medicine associated with OAP-189
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100 Patents (Medical) associated with OAP-189
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100 Deals associated with OAP-189
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
ObesityPhase 1-
Pfizer Inc.Pfizer Inc.
01 Apr 2011
Diabetes Mellitus, Type 2Phase 1
United States
Pfizer Inc.Pfizer Inc.
02 Sep 2009
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
NCT00970593 (3283K1-1008-US, CTgov)
Phase 1
Diabetes Mellitus, Type 2
92
(OAP-189 0.2 mg IR)
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-
02 Nov 2020
(OAP-189 0.4 mg IR)
jdezleradq = qokqvegdpu pislewfjxb (dqqhwacxut, qfqwnnybtt - cyyfjngyff)
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Translational Medicine

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Deal

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Core Patent

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Clinical Trial

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Approval

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Biosimilar

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Competitive landscape of biosimilars in different countries/locations. Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3.

Regulation

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