This is an open-label dose escalation study designed to evaluate the safety and pharmacokinetics of ABBV-085 and determine the recommended Phase 2 dose (as monotherapy or in combination with standard therapies) in subjects with advanced solid tumors.

Start Date18 Sep 2015

Sponsor / Collaborator

AbbVie, Inc.

100 Clinical Results associated with Samrotamab vedotin

100 Translational Medicine associated with Samrotamab vedotin

100 Patents (Medical) associated with Samrotamab vedotin

589

Literatures (Medical) associated with Samrotamab vedotin

01 Apr 2025·Bioorganic & Medicinal Chemistry

Fine-tuning phenoxy silyl scaffolds for the development of glutathione-responsive prodrugs and antibody–drug conjugates

Article

Author: Jiang, Yuecheng ; Wang, Huihui ; Huangfu, Shangwei ; Jiang, Biao ; Chen, Hongli ; Wei, Ding ; Qi, Cheng ; Yu, Xianqiang

Silyl ether is particularly attractive for application in drug development for its easy preparation, non-toxicity and remarkable biocompatibility. Earlier studies relied on the use of intracellular acidic conditions to induce the cleavage of alkoxy silyl ethers. However, acidic conditions are not suitable to trigger the release of phenoxy silyl ethers, since they are more stable under acidic conditions compared with neutral conditions. We explored the vulnerability of the phenoxy silyl ether towards biological nucleophilic reagents and found that glutathione (GSH) could effectively and selectively induce the cleavage of phenoxy silyl ether. We also demonstrated that the rate of cleavage was controllable by adjusting the substituents on the phenyl ring. Phenoxy silyl ether-based prodrugs and antibody-drug conjugates (ADCs) were designed and synthesized, which could be effectively activated in cells with high GSH levels and there was an obvious therapeutic window between cells with different GSH levels.

19 Feb 2025·Bioconjugate Chemistry

A Unique Prodrug Targeting the Prostate-Specific Membrane Antigen for the Delivery of Monomethyl Auristatin E

Article

Author: Berkman, Clifford E. ; Savoy, Emily A. ; Bomba, Hunter N. ; Fulton, Melody D. ; Langton-Webster, Beatrice

Monomethyl auristatin E (MMAE) is a promising treatment option for patients diagnosed with prostate cancer (PCa); however, toxicities prevent MMAE from being administered as free drug. No MMAE-based treatment is currently marketed for PCa. Herein, we describe a small-molecule-drug conjugate, CTT2274, for the selective delivery of MMAE. CTT2274 is composed of a prostate-specific membrane antigen (PSMA)-binding scaffold, a biphenyl motif, a pH-sensitive phosphoramidate linker, and MMAE payload. We demonstrate that CTT2274 shows selective binding to PSMA, which is overexpressed on PCa cells, and induces tumor cell death in vitro. In a patient-derived xenograft tumor model of PCa in mice, we show that weekly intravenous dosing of CTT2274 at 3.6 mg/kg for six weeks is superior to treatment with free MMAE at equivalent doses. Mice treated with CTT2274 experienced prolonged tumor suppression and significantly greater overall survival than mice treated with PBS. Additionally, the safety of CTT2274 compared to an equivalent dose of MMAE was assessed in healthy, non-tumor-bearing mice. Our results demonstrate that CTT2274 therapy is as efficacious as MMAE, results in superior overall survival, and has a more favorable safety profile. Together, these data indicate that CTT2274 is a candidate for clinical translation for the treatment of PCa.

18 Feb 2025·ACS Nano

Nanobody-Mediated Cellular Uptake Maximizes the Potency of Polylysine Dendrimers While Preserving Solid Tumor Penetration

Article

Author: Feeney, Orlagh M. ; Johnston, Angus P.R. ; Humphries, James ; Noi, Leo ; Owen, David J. ; Porter, Christopher J.H. ; Cullinane, Carleen ; Fletcher, Nicholas L. ; Yuen, Daniel ; Houston, Zachary H ; Thurecht, Kristofer J. ; Reitano, Pauline ; Hufton, Richard ; McLeod, Victoria M. ; Shengule, Sudhir ; Tsegay, Sammi

Dendrimers are branched macromolecular structures that are useful nanocarriers for small-molecule drugs, such as cancer therapeutics. Their small size permits penetration into solid tumors, coupled with functionalization with a low-fouling PEG coating that minimizes transient cellular interactions and enhances plasma circulation time. While PEGylated dendrimers show significant promise as anticancer therapeutics, there is potential to increase tumor cell specificity and drive uptake of drugs into cells by conjugating cell-targeting ligands onto the dendrimers. To achieve this, we used an expanded genetic code and bio-orthogonal click chemistry to functionalize monomethyl auristatin E (MMAE)-loaded PEGylated dendrimers with a single tumor cell-targeting nanobody per dendrimer. The uniform addition of a single nanobody ligand facilitated greater intracellular uptake of the drug payload into HER2-positive target cells, while preserving the desirable circulatory characteristics of dendrimers. While the nanobody-dendrimer conjugates show similar levels of tumor infiltration over 24 h compared to unmodified dendrimers, the targeted dendrimers had significantly greater inhibition of tumor growth and long-term retention in the tumors. Our results highlight that biodistribution studies alone are poor predictors of therapeutic performance. The controlled conjugation strategy presented here preserves the size advantage and tissue penetration of dendrimers while maximizing targeted cellular uptake and potency in difficult-to-access solid tumor tissue.

100 Deals associated with Samrotamab vedotin

R&D Status

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Indication	Highest Phase	Country/Location	Organization	Date
Advanced Malignant Solid Neoplasm	Phase 1	United States	AbbVie, Inc.	18 Sep 2015
Breast Cancer	Phase 1	France	AbbVie, Inc.	18 Sep 2015
Breast Cancer	Phase 1	United States	AbbVie, Inc.	18 Sep 2015
Breast Cancer	Phase 1	Spain	AbbVie, Inc.	18 Sep 2015
Malignant Fibrous Histiocytoma	Phase 1	Spain	AbbVie, Inc.	18 Sep 2015
Malignant Fibrous Histiocytoma	Phase 1	France	AbbVie, Inc.	18 Sep 2015
Malignant Fibrous Histiocytoma	Phase 1	United States	AbbVie, Inc.	18 Sep 2015
Squamous Cell Carcinoma of Head and Neck	Phase 1	Spain	AbbVie, Inc.	18 Sep 2015
Squamous Cell Carcinoma of Head and Neck	Phase 1	United States	AbbVie, Inc.	18 Sep 2015
Squamous Cell Carcinoma of Head and Neck	Phase 1	France	AbbVie, Inc.	18 Sep 2015

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


NCT02565758 (ASCO2019)	Phase 1	Sarcoma \| Solid tumor	78	ABBV-085	(jfqexujmfv) = Dose-limiting toxicities occurred at 3.6 mg/kg (n = 1; anemia) ogkkrdyrne (mqolhqeqlk ) View more	Positive	26 May 2019

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