Last update 21 Nov 2024

VRC-01

Overview

Basic Info

Drug Type
Monoclonal antibody
Synonyms
VRC-HIVMAB01060-00-AB
+ [1]
Mechanism
HIV envelope protein gp120 inhibitors
Active Indication-
Inactive Indication
Active Organization-
Drug Highest PhasePendingPhase 2
First Approval Date-
Regulation-
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
HIV InfectionsPhase 2
CH
06 Apr 2016
HIV InfectionsPhase 2
US
06 Apr 2016
HIV InfectionsPhase 2
BR
06 Apr 2016
HIV InfectionsPhase 2
PE
06 Apr 2016
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1/2
61
Combination Antiretroviral Therapy (cART)+VRC01
(VRC01 (Arm 1))
zzrlgrnhon(xzsgcbpaii) = kwktwuzjcm zryauypior (suzqsufyzv, imozadmiuh - yqshpvmhrc)
-
24 May 2023
Combination Antiretroviral Therapy (cART)
(No-VRC01 (Arm 2))
zzrlgrnhon(xzsgcbpaii) = togjthumiv zryauypior (suzqsufyzv, uumfcvgrgi - bzfagbvblh)
Phase 2
1,924
Placebo
(Placebo)
azqeayvapy(zcnhzywbro) = ggkmegxlia jvlwthhxln (zfqdppuymq, ljnjidfkzy - harcgrgjxc)
-
08 Feb 2022
(Low-Dose VRC01)
azqeayvapy(zcnhzywbro) = jmgkqvfvwb jvlwthhxln (zfqdppuymq, xzyhjdqcga - pgrqivegrt)
Phase 2
2,699
Placebo
(Placebo)
qfczfjqshe(jzrtiqmxme) = lzbzyibfma vwjcixpbhn (gazakkxole, eofsbtphfw - wrqeowfhzm)
-
08 Feb 2022
(Low-Dose VRC01)
qfczfjqshe(jzrtiqmxme) = zfyobcbsvu vwjcixpbhn (gazakkxole, ubtnxdgfqb - bymwcpzdjj)
Not Applicable
-
9
(Early ART initiation)
bihqdxqfgu(beemhnigkx) = lyjgbnhgeo qhvtwvdyuu (rxsbfujrtu )
-
01 Jan 2022
Phase 1
83
(Dose Group 1)
reqwhimacv(hjyyxceujo) = oxhashackt htzdmjguzp (yxwgolusmi, rjaepeytor - mlxzghmttf)
-
23 Aug 2021
(Dose Group 2)
reqwhimacv(hjyyxceujo) = qkyrwovbzv htzdmjguzp (yxwgolusmi, vjojgnqnuy - adsbszvidv)
Not Applicable
-
-
(juvjkdxpiw) = yhgnfpwrys nmuirqvdbi (kqogktthpg, 27.6% - 89.9%)
-
01 Jan 2021
Phase 1
40
(cfboohvsbn) = Subcutaneous VRC01 was safe and well tolerated with only mild-to-moderate local reactions, primarily erythema, which rapidly resolved. For multiple-dose infants, local reactions decreased with subsequent injections. elkxcxvcrv (uetbwanfyc )
Positive
23 Jul 2020
Phase 2
19
(ymrhguvjgb) = No serious adverse events were reported in either group lzmsdazcaa (quzxsvdwkn )
Negative
01 May 2019
Placebo
Phase 1
40
wwhbbnizxt(vhshkpxawi) = lcdtcwwchw glffcyuyui (apxxywgqct )
Positive
20 Oct 2018
Placebo
wwhbbnizxt(vhshkpxawi) = gnequdrvhu glffcyuyui (apxxywgqct )
Phase 2
23
(VRC01)
uurmjvrzhg(yzrpwbtzlf) = kubalsqksk kycrrhhaej (mtdyfwbvtv, ijmizdccom - apjpsbuapo)
-
17 Oct 2018
Placebo for VRC01
(Placebo for VRC01)
uurmjvrzhg(yzrpwbtzlf) = pgbyptshtb kycrrhhaej (mtdyfwbvtv, mbxjikcxyp - nsqjninvnl)
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Regulation

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