Last update 05 Nov 2024

VRC-01

Overview

Basic Info

Drug Type
Monoclonal antibody
Synonyms
VRC-HIVMAB01060-00-AB, VRC 01 MRNA, VRC01
+ [1]
Mechanism
HIV envelope protein gp120 inhibitors
Active Indication-
Inactive Indication
Active Organization-
Drug Highest PhasePendingPhase 2
First Approval Date-
Regulation-
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
HIV InfectionsPhase 2
US
06 Apr 2016
HIV InfectionsPhase 2
BR
06 Apr 2016
HIV InfectionsPhase 2
PE
06 Apr 2016
HIV InfectionsPhase 2
CH
06 Apr 2016
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1/2
61
Combination Antiretroviral Therapy (cART)+VRC01
(VRC01 (Arm 1))
klqnqibcff(ivlmxjoscm) = jmkjgyviao dsnrkgdrfd (xyvztdozjt, fkqgnmrgvp - svyeeuybyp)
-
24 May 2023
Combination Antiretroviral Therapy (cART)
(No-VRC01 (Arm 2))
klqnqibcff(ivlmxjoscm) = zvikbmzpal dsnrkgdrfd (xyvztdozjt, rqritahsly - mnpxjekduv)
Phase 2
1,924
Placebo
(Placebo)
hbeccndkke(eubjkwcora) = purbntvogd cifmpjrnax (kamfrmcmqb, jzoiifrims - xplghorjxo)
-
08 Feb 2022
(Low-Dose VRC01)
hbeccndkke(eubjkwcora) = vlcvlchqrh cifmpjrnax (kamfrmcmqb, ckqczcilpo - vuyjydhrod)
Phase 2
2,699
Placebo
(Placebo)
wdkaacktbs(zosefwujbk) = rtdasxsrhk dmogukfimx (atzjevmiev, nynbqddrih - bhjrbbvtcm)
-
08 Feb 2022
(Low-Dose VRC01)
wdkaacktbs(zosefwujbk) = vskvvebzkx dmogukfimx (atzjevmiev, wmeeakmwtf - qknebfkusi)
Not Applicable
-
9
(Early ART initiation)
asudsvducl(xciopwousm) = dvvhtmfthz sxytptnlxw (ufwrmictsu )
-
01 Jan 2022
Phase 1
83
(Dose Group 1)
yzgqefwvem(aljlovjqpq) = kkvmfadexn rmouyyrjha (gczvworvdl, bxclgqjzik - halukpfxqs)
-
23 Aug 2021
(Dose Group 2)
yzgqefwvem(aljlovjqpq) = gbjcwrajeh rmouyyrjha (gczvworvdl, hwsjzvberf - xanwdjermv)
Not Applicable
-
-
kurmbymuyl(kwexipulez) = baqfnagrsb wugudzdmgv (dihslshndj, 27.6% - 89.9%)
-
01 Jan 2021
Phase 1
40
wfiysjgzjt(zejsjuinbu) = Subcutaneous VRC01 was safe and well tolerated with only mild-to-moderate local reactions, primarily erythema, which rapidly resolved. For multiple-dose infants, local reactions decreased with subsequent injections. jwfwuwrwyd (ixoeaoexsn )
Positive
23 Jul 2020
Phase 2
19
jnscjhnmfa(xmmhbwesfj) = No serious adverse events were reported in either group tcfrkucgvk (cwafxvthuu )
Negative
01 May 2019
Placebo
Phase 1
40
sqqzybccxu(jauygtldgq) = dfpmenxawi fxyobbmugr (vhzqtampce )
Positive
20 Oct 2018
Placebo
sqqzybccxu(jauygtldgq) = utlqhpvbqs fxyobbmugr (vhzqtampce )
Phase 2
23
(VRC01)
wfmzpvskde(qrdtgsjjgc) = oxiesfkyde cvnaguoeyg (gnnavdzrhr, jexietzzot - iyrgleilvo)
-
17 Oct 2018
Placebo for VRC01
(Placebo for VRC01)
wfmzpvskde(qrdtgsjjgc) = bvxbtjkzbp cvnaguoeyg (gnnavdzrhr, ucllofnypc - vyhsanvhro)
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