Last update 01 Nov 2024

Neflamapimod

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Neflamapimod (USAN)
+ [2]
Mechanism
p38 MAPK inhibitors(P38 mitogen-activated protein kinase inhibitors), p38α inhibitors(P38 α mitogen-activated protein kinase inhibitors)
Originator Organization
Inactive Organization
Drug Highest PhasePhase 2
First Approval Date-
Regulation-
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Structure

Molecular FormulaC19H9Cl2F2N3OS
InChIKeyVEPKQEUBKLEPRA-UHFFFAOYSA-N
CAS Registry209410-46-8

External Link

KEGGWikiATCDrug Bank
D10959--

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Lewy Body DiseasePhase 2-30 Mar 2023
Frontotemporal DementiaPhase 1
US
-
Huntington DiseasePreclinical
GB
08 Jul 2019
Alzheimer DiseaseDiscovery
NL
01 Apr 2015
Alzheimer DiseaseDiscovery
US
01 Apr 2015
Mild cognitive disorderDiscovery
NL
01 Apr 2015
Mild cognitive disorderDiscovery
US
01 Apr 2015
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
15
Placebo+neflamapimod
(Neflamapimod First)
tocrqvvbgv(vlihdqkvmm) = zxdabjtvjg rtmlwnasai (pzjpyggvxw, ezrxlokmej - caeygtnbjc)
-
06 Apr 2022
Placebo+neflamapimod
(Placebo First)
tocrqvvbgv(vlihdqkvmm) = oceweeedhu rtmlwnasai (pzjpyggvxw, jgvpdjvako - peuktzyeja)
Phase 2
91
(ujuxymbukt) = megvdaauwy uovrzuobaq (vckxljubnq )
Positive
10 Nov 2021
Placebo
-
Phase 2
91
ebsdrlewrw(ykfomkvjpv) = fgrefzfrij qqcajmkayb (edhesyrytp, mhhtwtchpm - mndnxrrlqd)
-
02 Nov 2021
Phase 2
161
Placebo
(Placebo Arm)
hroaydqnyy(jxnmbbgntk) = zkxctiiuuz dmxhydnuqw (mpqvygwvvn, gccgzzdofc - vtemeuwxwu)
-
27 Oct 2021
(Neflamapimod Arm)
hroaydqnyy(jxnmbbgntk) = ploafvmmyz dmxhydnuqw (mpqvygwvvn, gcmaciusct - qeeltckfig)
Phase 2
161
unlqmsnfwl(bufdvgrobn) = subjects in the highest quartile of trough plasma neflamapimod levels demonstrated positive trends, compared with placebo, in HLVT-R and WMS. myqjyxflkh (hxyuunuvou )
Negative
27 May 2021
Placebo
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Regulation

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