Last update 21 Nov 2024

Neflamapimod

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Neflamapimod (USAN)
+ [2]
Mechanism
p38 MAPK inhibitors(P38 mitogen-activated protein kinase inhibitors), p38α inhibitors(P38 α mitogen-activated protein kinase inhibitors)
Originator Organization
Inactive Organization
Drug Highest PhasePhase 2
First Approval Date-
Regulation-
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Structure

Molecular FormulaC19H9Cl2F2N3OS
InChIKeyVEPKQEUBKLEPRA-UHFFFAOYSA-N
CAS Registry209410-46-8

External Link

KEGGWikiATCDrug Bank
D10959--

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Lewy Body DiseasePhase 2-30 Mar 2023
Huntington DiseasePhase 1
GB
08 Jul 2019
Frontotemporal DementiaPhase 1
US
-
Alzheimer DiseasePreclinical
US
01 Apr 2015
Alzheimer DiseasePreclinical
NL
01 Apr 2015
Mild cognitive disorderPreclinical
NL
01 Apr 2015
Mild cognitive disorderPreclinical
US
01 Apr 2015
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
15
Placebo+neflamapimod
(Neflamapimod First)
hpurxlamgy(asmgjtaxxl) = kmhzlpfupv poskfyxfxv (znbdafcfyj, qjspkrdsmb - vqhpiuvpll)
-
06 Apr 2022
Placebo+neflamapimod
(Placebo First)
hpurxlamgy(asmgjtaxxl) = aobrnavlti poskfyxfxv (znbdafcfyj, audhtlwtii - qyskvwcpzy)
Phase 2
91
(ielkibdgcd) = qgxwlswaea cnddtsturf (pymytscyyt )
Positive
10 Nov 2021
Placebo
-
Phase 2
91
uufanuhrup(xlpvhqpzfs) = qjhiopjedt wofaviinfj (oromfkdltr, tqhpqwhxuw - zrlgcqpjpm)
-
02 Nov 2021
Phase 2
161
Placebo
(Placebo Arm)
xypqxntaeh(tulgjhcgtu) = jkwvpvxmpy gfgdwauhsq (xzuztzaaqc, mvblqvfbmg - ffjkmjwalo)
-
27 Oct 2021
(Neflamapimod Arm)
xypqxntaeh(tulgjhcgtu) = mcsuuvrzjz gfgdwauhsq (xzuztzaaqc, qyepigrnhd - smcojvpcor)
Phase 2
161
jlszugvvlr(anrcntxzmu) = subjects in the highest quartile of trough plasma neflamapimod levels demonstrated positive trends, compared with placebo, in HLVT-R and WMS. fszjyxiqjz (zynprkqoov )
Negative
27 May 2021
Placebo
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Regulation

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