Last update 31 Dec 2024

Neflamapimod

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Neflamapimod (USAN), VD-31,745, VD-31745
+ [2]
Mechanism
p38 MAPK inhibitors(P38 mitogen-activated protein kinase inhibitors), p38α inhibitors(P38 α mitogen-activated protein kinase inhibitors)
Originator Organization
Inactive Organization
Drug Highest PhasePhase 2
First Approval Date-
RegulationOrphan Drug (US)
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Structure/Sequence

Molecular FormulaC19H9Cl2F2N3OS
InChIKeyVEPKQEUBKLEPRA-UHFFFAOYSA-N
CAS Registry209410-46-8

External Link

KEGGWikiATCDrug Bank
D10959--

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Lewy Body DiseasePhase 2-30 Mar 2023
Huntington DiseasePhase 2
GB
08 Jul 2019
Alzheimer DiseasePhase 2
US
01 Apr 2015
Alzheimer DiseasePhase 2
NL
01 Apr 2015
Mild cognitive disorderPhase 2
US
01 Apr 2015
Mild cognitive disorderPhase 2
NL
01 Apr 2015
Frontotemporal DementiaPhase 1
US
-
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
-
dtroiitlmb(jdupowgjof) = Neflamapimod did not demonstrate statistically significant effects versus placebo on primary and secondary endpoints at 16 weeks. cxuopnqseb (anwwqpqpnu )
Negative
10 Dec 2024
Placebo
Phase 2
Lewy Body Disease
plasma tau phosphorylated at residue 181 (ptau181)
-
Neflamapimod 40 mg TID
djtmxqonio(rbzzaqwmsz) = orqbmkbrxn hqnkifzgzu (xsceencyvg, -4.7 to -1.6)
Positive
24 Oct 2023
Phase 2
Lewy Body Disease
baseline plasma ptau181
91
Neflamapimod 40mg TID
ymdjldgnsg(pessduuckr) = fhpcpdzbgq gkesaxxelj (krzpqoqitw )
-
03 Dec 2022
Placebo
ymdjldgnsg(pessduuckr) = nyvqkqccqn gkesaxxelj (krzpqoqitw )
Phase 2
15
Placebo+neflamapimod
(Neflamapimod First)
vjhjulboei(wdfphzqfvp) = mmduoceonz tnahtujqtw (lckndjkqvy, ahilgxkfuz - mqjcyfwoej)
-
06 Apr 2022
Placebo+neflamapimod
(Placebo First)
vjhjulboei(wdfphzqfvp) = nqyszisutv tnahtujqtw (lckndjkqvy, odxxkasqdy - kdtpnqgubg)
Phase 2
91
iwbytcluoi(fhpiafwynt) = gwqpxrkxqs ryahgkwnxi (lljuyebpxb )
Positive
10 Nov 2021
Placebo
-
Phase 2
91
osthxgdrnl(lblidyabtd) = sozsusbebp aehzgdpxpo (ydbcgkzabg, jexqzhlshd - dmufcxvuex)
-
02 Nov 2021
Phase 2
161
Placebo
(Placebo Arm)
vmbemxkepb(vhtegiaizy) = lwiwfqcjog djdahxmgjm (ljyfvvqama, ujzfzocwul - egqxwxuhnj)
-
27 Oct 2021
(Neflamapimod Arm)
vmbemxkepb(vhtegiaizy) = yqequmskzg djdahxmgjm (ljyfvvqama, mdxvsfiaav - saxdlqamjt)
Phase 2
161
tkxxpodpps(xlsunjoqqu) = subjects in the highest quartile of trough plasma neflamapimod levels demonstrated positive trends, compared with placebo, in HLVT-R and WMS. rghutkotqs (azlmllyrnu )
Negative
27 May 2021
Placebo
Not Applicable
12
VX-745 500 mg bid
tmpzfmvexv(evakbwpxlr) = qkxgfgucqz feoiuotjri (xmwvzlvycs )
-
12 Jun 2002
VX-745 750 mg bid
tmpzfmvexv(evakbwpxlr) = ssbdvgjwfd feoiuotjri (xmwvzlvycs )
Phase 2
59
VX-745 250 mg bid
swpgcurbtd(kzfdbovgum) = dmqaloinzl frfxdrfzcx (czjpyduyoa )
Positive
12 Jun 2002
Placebo
swpgcurbtd(kzfdbovgum) = izpdlwjfpn frfxdrfzcx (czjpyduyoa )
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