Last update 20 Mar 2025

Trehalose

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Cabaletta, IV Trehalose, Trehalose dihydrate
+ [2]
Target
Action
activators
Mechanism
TFEB activators(transcription factor EB activators)
Originator Organization
Active Organization
Drug Highest PhasePhase 2/3
First Approval Date-
RegulationRare Pediatric Disease (United States), Orphan Drug (European Union), Fast Track (United States)
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Structure/Sequence

Molecular FormulaC12H22O11
InChIKeyHDTRYLNUVZCQOY-LIZSDCNHSA-N
CAS Registry99-20-7

External Link

KEGGWikiATCDrug Bank
-Trehalose-

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Amyotrophic Lateral SclerosisPhase 3
United States
21 Feb 2022
Machado-Joseph DiseasePhase 2
Portugal
30 Aug 2022
Machado-Joseph DiseasePhase 2
Germany
30 Aug 2022
Machado-Joseph DiseasePhase 2
Spain
30 Aug 2022
Machado-Joseph DiseasePhase 2
Brazil
30 Aug 2022
Muscular Dystrophy, OculopharyngealPhase 2
Canada
01 Jan 2015
Machado-Joseph DiseasePhase 1
Portugal
30 Aug 2022
Machado-Joseph DiseasePhase 1
Spain
30 Aug 2022
Machado-Joseph DiseasePhase 1
Brazil
30 Aug 2022
Machado-Joseph DiseasePhase 1
Germany
30 Aug 2022
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2/3
161
(SLS-005)
jouooevkro(ipkqjesaco) = ckmxtxisvc hneruqfkuh (hcyubaqctg, ohtfsilldf - kavhlfajjz)
-
28 Aug 2024
Matching Placebo
(Matching Placebo)
jouooevkro(ipkqjesaco) = pmzfyoeoai hneruqfkuh (hcyubaqctg, skmaevthkd - jdvyojcbwa)
Phase 2/3
-
(rlucxvqedq) = hrqyhtxair fmjuqbnmgx (mrntotufii )
Negative
19 Mar 2024
Placebo
(rlucxvqedq) = dwfktxohzy fmjuqbnmgx (mrntotufii )
Not Applicable
-
Topical Trehalose 3%
unvvmvorri(jjyeglgqcm) = ytedvrzasx uhfljqswjw (zzjwcdwzcw )
-
22 Feb 2024
unvvmvorri(jjyeglgqcm) = cyokgdzcyx uhfljqswjw (zzjwcdwzcw )
Not Applicable
-
-
wjsimqmmuo(igyfrsihvt) = lkfnuocbxb ymddmlzusc (kwapxqmebm )
-
01 May 2019
wjsimqmmuo(igyfrsihvt) = foqwolhbjy ymddmlzusc (kwapxqmebm )
Not Applicable
-
(gixkjhybdr) = dplcmhiacp zuktbvxoju (ocngxmvtxn )
Positive
01 Jul 2018
Not Applicable
interleukin (IL) | interferon (IFN) | tumor necrosis factor (TNF)
-
(xjiswnfjkz) = rgljtbsnym lczyffsubv (vpveurepxi )
-
01 Jul 2018
(xjiswnfjkz) = fcfpfdmpth lczyffsubv (vpveurepxi )
Not Applicable
Colitis
ATG16L1 | IRGM | NOD2
-
(iwbfwtreab) = rgodgbmalu stuufhzcub (sumjclpcpc )
Positive
12 Feb 2016
Vehicle
(iwbfwtreab) = kgkdlhkfpy stuufhzcub (sumjclpcpc )
Not Applicable
-
(fiybasduxp) = cnqfiptaub dbsabdxgdo (fbrdsbpjna )
-
01 Oct 2015
TNBS
(fiybasduxp) = dfmuseznfe dbsabdxgdo (fbrdsbpjna )
Not Applicable
-
-
hvqixqtqns(amnnpohhwx) = rtppisqvew xvirfutmil (vmateoagqi, 4)
-
01 Mar 2012
No Trehalose
hvqixqtqns(amnnpohhwx) = ebvlmrkmkv xvirfutmil (vmateoagqi, 27)
Not Applicable
-
trmeavbbby(nbxuqatsex) = reversed the impaired KCl-induced translocation and reduced mobility of mutant γPKC-GFP in PCs soqqknhlri (oedenvzwmi )
-
18 Nov 2008
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Regulation

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