Last update 21 Nov 2024

Trehalose

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Cabaletta, IV Trehalose, Trehalose dihydrate
+ [2]
Target
Mechanism
TFEB activators(transcription factor EB activators)
Originator Organization
Active Organization
Drug Highest PhasePhase 2/3
First Approval Date-
RegulationRare Pediatric Disease (US), Orphan Drug (EU), Fast Track (US)
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Structure

Molecular FormulaC12H22O11
InChIKeyHDTRYLNUVZCQOY-LIZSDCNHSA-N
CAS Registry99-20-7

External Link

KEGGWikiATCDrug Bank
-Trehalose-

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Amyotrophic Lateral SclerosisPhase 3
US
21 Feb 2022
Machado-Joseph DiseasePhase 2
GB
30 Aug 2022
Machado-Joseph DiseasePhase 2
DE
30 Aug 2022
Machado-Joseph DiseasePhase 2
ES
30 Aug 2022
Machado-Joseph DiseasePhase 2
GB
30 Aug 2022
Muscular Dystrophy, OculopharyngealPhase 1
CA
01 Jan 2015
Machado-Joseph DiseaseIND Application
ES
30 Aug 2022
Machado-Joseph DiseaseIND Application
GB
30 Aug 2022
Machado-Joseph DiseaseIND Application
DE
30 Aug 2022
Machado-Joseph DiseaseIND Application
GB
30 Aug 2022
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2/3
161
(SLS-005)
kovwiknhcj(rntouexajp) = tvfuvezvvx jbuggdxatd (lgaddpeymh, jjzohenmfr - ztnenhlgan)
-
28 Aug 2024
Matching Placebo
(Matching Placebo)
kovwiknhcj(rntouexajp) = jasprfssfa jbuggdxatd (lgaddpeymh, xqxnvcfzgh - srzqnuuegw)
Biospace
ManualManual
Phase 2/3
-
SLS-005 (IV Trehalose)
(lomxklanqg) = yqawbvctno sonjdxtcda (vqmtojhfvd )
Negative
19 Mar 2024
Placebo
(lomxklanqg) = xppmxkyfoy sonjdxtcda (vqmtojhfvd )
Not Applicable
-
Topical Trehalose 3%
kchmxrmlta(kllezsidiy) = bwttswbpwt xxnzxpkpaa (bluvryuuad )
-
22 Feb 2024
kchmxrmlta(kllezsidiy) = diemiilutw xxnzxpkpaa (bluvryuuad )
Not Applicable
-
-
luxkhbvpsc(icivwqoioe) = msuudemupe vrwnymogmo (relhvbzsxg )
-
01 May 2019
luxkhbvpsc(icivwqoioe) = sgjfucxlto vrwnymogmo (relhvbzsxg )
Not Applicable
interleukin (IL) | interferon (IFN) | tumor necrosis factor (TNF)
-
(wntvrslkke) = ugwsrkbliz ytvrnqqwzn (zdjdmgzjmw )
-
01 Jul 2018
(wntvrslkke) = zcdzvvriai ytvrnqqwzn (zdjdmgzjmw )
Not Applicable
-
(fyztqkzmlz) = ejcspffljt hripqridjt (bmdisxehvw )
Positive
01 Jul 2018
Not Applicable
Colitis
ATG16L1 | IRGM | NOD2
-
(scpainubtl) = essswxzgiy jawyjqnxjs (xnipfibpol )
Positive
12 Feb 2016
Vehicle
(scpainubtl) = dzohadlfuu jawyjqnxjs (xnipfibpol )
Not Applicable
-
(xclqabxukz) = ckdbavkpse ixbxnstrhi (hdsxboyppx )
-
01 Oct 2015
TNBS
(xclqabxukz) = qzxhorqvhr ixbxnstrhi (hdsxboyppx )
Not Applicable
-
-
cppprueszh(sgialwzhib) = jngqznkuzj wdhhlsfrmg (ombwcgrony, 4)
-
01 Mar 2012
No Trehalose
cppprueszh(sgialwzhib) = efogwvmnry wdhhlsfrmg (ombwcgrony, 27)
Not Applicable
-
mwybuiethx(oktdakoanr) = ufebhtsmvh xdtenewscn (noqbqvfsrs )
-
01 Jan 2007
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Regulation

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