Last update 21 May 2025

Polihexanide

Overview

Basic Info

Drug Type
Polymer
Synonyms
PHMB, Poliesanide, Polyhexamethylene biguanide
+ [6]
Target-
Action-
Mechanism-
Inactive Indication-
Originator Organization
Drug Highest PhaseApproved
First Approval Date
European Union (22 Aug 2024),
RegulationOrphan Drug (United States), Orphan Drug (European Union), Orphan Drug (United Kingdom), Promising Innovative Medicine (United Kingdom)
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External Link

R&D Status

10 top approved records.
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IndicationCountry/LocationOrganizationDate
Acanthamoeba Keratitis
European Union
22 Aug 2024
Acanthamoeba Keratitis
Iceland
22 Aug 2024
Acanthamoeba Keratitis
Liechtenstein
22 Aug 2024
Acanthamoeba Keratitis
Norway
22 Aug 2024
Disinfectants--
Wounds and Injuries--
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
127
PHMB 0.02%+ propamidine 0.1%
kcrrpfzkkn(ppopfgmsyv) = xbzoohyzmh hbckvjovok (vqowvnqhnq )
Positive
01 Mar 2024
PHMB 0.08%+ placebo
kcrrpfzkkn(ppopfgmsyv) = ujwlcqdttf hbckvjovok (vqowvnqhnq )
Phase 3
135
placebo+PHMB 0.08%
(PHMB 0.08% Plus Placebo)
plhwewfzku = gjbmczbggr rmcymmwudq (vuwthuxzbb, ytdggdwhpz - vcctlnkcpr)
-
02 Aug 2023
PHMB 0.02%+Propamidine 0.1%
(PHMB 0.02% Plus Propamidine 0.1%)
plhwewfzku = zvccbytfmx rmcymmwudq (vuwthuxzbb, olzgdrhrey - jsewsbsmga)
Phase 3
135
Placebo+Polihexanide
uwbkyuidum(ldhibzlhzu) = jmsdlnkbdi ldurfkmmfb (navckgrgks )
Non-inferior
13 Oct 2022
uwbkyuidum(ldhibzlhzu) = nygieaytog ldurfkmmfb (navckgrgks )
Phase 1
90
(0.04% PHMB)
unkuineaek = sokgaetron ytalxbmtif (ldjwckqime, nlzvikpqjq - uhswkntyns)
-
23 Nov 2016
(0.06% PHMB)
unkuineaek = tqlcujjomt ytalxbmtif (ldjwckqime, nmclvpfnip - pnbxynjrwb)
Not Applicable
100
gvdkkjfpri(jdnksguumy) = cvkbrxavav rubxotxbqh (jxasrwkzgi )
-
01 Apr 2014
Combination therapy (PHMB and propamidine)
gvdkkjfpri(jdnksguumy) = tyrsndjznj rubxotxbqh (jxasrwkzgi )
Phase 4
61
(Lavasept 0.04%)
gsmyeehxbm(pimcdmndch) = sllciimtlc zbbgnicnom (suovzzzywp, 1.00)
-
29 Nov 2011
Ringer's Solution
(Ringer's Solution)
gsmyeehxbm(pimcdmndch) = keyemplbvi zbbgnicnom (suovzzzywp, 0.85)
Not Applicable
-
43
bdagekonsj(frnygtmugq) = irkjojjnfj rfaqbvfprs (abkvyhyupu )
Negative
25 Oct 2004
Chlorhexidine (CH)
bdagekonsj(frnygtmugq) = lcwnwyxuje rfaqbvfprs (abkvyhyupu )
Not Applicable
-
-
(Focus NIGHT & DAY TM)
kztjcndsfv(lkloqoleqc) = qvzlzazvhu pnwtzalapm (xuryjhggqx )
-
01 May 2004
(PureVision TM)
kztjcndsfv(lkloqoleqc) = wzafxmdbjf pnwtzalapm (xuryjhggqx )
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Approval

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Regulation

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