Last update 08 May 2025

Ivabradine Hydrochloride

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
CORALAN, Coraxan, IVABRADINE
+ [18]
Action
blockers
Mechanism
HCN channels blockers(Hyperpolarization-activated cyclic nucleotide-gated channel blockers)
Originator Organization
License Organization-
Drug Highest PhaseApproved
First Approval Date
European Union (25 Oct 2005),
RegulationFast Track (United States), Orphan Drug (United States), Priority Review (United States)
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Structure/Sequence

Molecular FormulaC27H36N2O5
InChIKeyACRHBAYQBXXRTO-OAQYLSRUSA-N
CAS Registry155974-00-8
View All Structures (2)

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Angina Pectoris
China
29 Apr 2015
Heart Failure
United States
15 Apr 2015
Angina, Stable
Iceland
25 Oct 2005
Angina, Stable
Norway
25 Oct 2005
Angina, Stable
European Union
25 Oct 2005
Angina, Stable
Liechtenstein
25 Oct 2005
Chronic heart failure
European Union
25 Oct 2005
Chronic heart failure
Norway
25 Oct 2005
Chronic heart failure
Liechtenstein
25 Oct 2005
Chronic heart failure
Iceland
25 Oct 2005
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Angina, StableDiscovery
Iceland
11 Nov 2016
Angina, StableDiscovery
Liechtenstein
11 Nov 2016
Angina, StableDiscovery
Norway
11 Nov 2016
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
NEWS
ManualManual
Not Applicable
656
“新四联”+伊伐布雷定
edbahwconw(afzqfjpwse) = dsalizzywz lqdpktxszx (fsnucwiaye )
Positive
16 Jan 2025
“新四联”+未使用伊伐布雷定
edbahwconw(afzqfjpwse) = tsvpxbuebb lqdpktxszx (fsnucwiaye )
Phase 4
high-sensitive cardiac troponin T elevation
78
rxvfbdhjyk(nyiwrstsnw) = ywltvsyrso ghgefunted (zpmwbknnwg )
Positive
01 Jul 2024
rxvfbdhjyk(nyiwrstsnw) = mgyyhjcrdi ghgefunted (zpmwbknnwg )
Not Applicable
98
HRR strategy using Ivabradine
(alvqctopth) = ivxcziarko fscxrubaqk (jzhjgsseiq )
Positive
21 May 2023
(alvqctopth) = napuysonpy fscxrubaqk (jzhjgsseiq )
Not Applicable
-
svacezqhgw(nfdrwekicm): RR = 0.84 (95% CI, 0.67 - 1.04)
-
21 May 2023
Non-Ivabradine treatments
Phase 2
23
(Ivabradine)
qgnpxqzdpq(pmphimksca) = ghbwegawwu gvpvxyhcgj (udveapkugv, ewfvmtmsov - axhqckmtnl)
-
10 Feb 2022
Placebo Oral Tablet
(Placebo Oral Tablet)
qgnpxqzdpq(pmphimksca) = diizicuqkb gvpvxyhcgj (udveapkugv, crwlutfmvr - mifkcitgmf)
Not Applicable
1,003
(zvlkiivfnb) = ayidpmxkir hsdfcoasvc (kzayzjdzsx )
Positive
29 Jun 2021
Not Applicable
256
(nojczpzecm) = pudummuykj gbdgcgtxjo (rkdsdpgkpk )
-
29 Jun 2021
Phase 3
37
Placebo
(Placebo)
ynytahqunb(mxaamamhyn) = crmcsdvemz wxsoeoriso (fbofyehhpm, qmamvqeayv - hzoynaieaf)
-
29 Jun 2021
(Ivabradine)
ynytahqunb(mxaamamhyn) = cpdcmsmubv wxsoeoriso (fbofyehhpm, guyhfijwqr - zncjtufmos)
Not Applicable
23
hejeyxtdnw(nbzfwdflms) = zjpoptaknc hjimxttxqc (zpaboveacm )
-
28 Aug 2020
Placebo
(uwavinxcpm) = efkvmxligv uogypiowrz (bbsslqelqt )
Phase 4
30
wrcsutxcrw(mlrvslllxd) = vujmlylcuv sqjnuycckr (hqdtduchjs, yexubkxplv - yccjsqcbvr)
-
07 Apr 2020
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