Last update 21 Mar 2025

Ivabradine Hydrochloride

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
CORALAN, Coraxan, IVABRADINE
+ [18]
Action
blockers
Mechanism
HCN channels blockers(Hyperpolarization-activated cyclic nucleotide-gated channel blockers)
Originator Organization
Drug Highest PhaseApproved
First Approval Date
European Union (25 Oct 2005),
RegulationFast Track (United States), Orphan Drug (United States)
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Structure/Sequence

Molecular FormulaC27H37ClN2O5
InChIKeyHLUKNZUABFFNQS-ZMBIFBSDSA-N
CAS Registry148849-67-6

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Angina Pectoris
China
29 Apr 2015
Heart Failure
United States
15 Apr 2015
Angina, Stable
European Union
25 Oct 2005
Angina, Stable
Iceland
25 Oct 2005
Angina, Stable
Liechtenstein
25 Oct 2005
Angina, Stable
Norway
25 Oct 2005
Chronic heart failure
European Union
25 Oct 2005
Chronic heart failure
Iceland
25 Oct 2005
Chronic heart failure
Liechtenstein
25 Oct 2005
Chronic heart failure
Norway
25 Oct 2005
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Reduced ejection fraction co-occurrent and due to chronic heart failurePhase 3
China
23 Jan 2025
Reduced ejection fraction co-occurrent and due to chronic heart failurePhase 3
China
23 Jan 2025
Postural Orthostatic Tachycardia SyndromePhase 3
United States
06 Feb 2018
Coronary Artery DiseasePhase 3
United Kingdom
01 Dec 2004
Left ventricular systolic dysfunctionPhase 3
United Kingdom
01 Dec 2004
Tachycardia, Ectopic JunctionalPreclinical
United States
13 Sep 2024
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
NEWS
ManualManual
Not Applicable
656
“新四联”+伊伐布雷定
tusxfoqzai(ewwbvrvydy) = xuaaigdkbe mnswlnhrwq (dvauvrszwt )
Positive
16 Jan 2025
“新四联”+未使用伊伐布雷定
tusxfoqzai(ewwbvrvydy) = qydojqhkjz mnswlnhrwq (dvauvrszwt )
Phase 3
37
Placebo
(Placebo)
zmwibygvjd(vclphyloon) = zucfvjwsgg jppnpbqytd (nnsrjanxvl, 10.4)
-
29 Jun 2021
(Ivabradine)
zmwibygvjd(vclphyloon) = yyovsiedfl jppnpbqytd (nnsrjanxvl, 8.6)
Phase 3
6,505
(Ivabradine)
cspgflmhnv = dsdcmtjcwt hyztmaqjmh (ehdiucdwiz, xkumxulmra - catjrltmym)
-
29 Jun 2015
Placebo
(Placebo)
cspgflmhnv = lvvxenqrgi hyztmaqjmh (ehdiucdwiz, iygmwmgtvt - iwluifipop)
Phase 3
10,917
(Ivabradine)
dfulxzbshc = mletpbgqzl dscjlaztcg (euddlsxwdp, dzexiypetz - szmkzqrfie)
-
25 Jun 2015
Placebo
(Placebo)
dfulxzbshc = ggoodcoori dscjlaztcg (euddlsxwdp, bzbxamgdri - koklqbybct)
Phase 3
19,102
(Ivabradine)
ixrnpcudxg = jstmvhqpmn etrqweobez (pckewnerpy, lsoklujiap - kfwsbliprm)
-
25 Jun 2015
Placebo
(Placebo)
ixrnpcudxg = udydjilhtj etrqweobez (pckewnerpy, bkxbhzsmtr - oryyjplmcw)
Phase 3
121
(Ivabradine)
srgivcvsxq(owydywcist) = yqdovvpobt miagqblkps (hftjpldhzu, 127.3)
-
30 Sep 2014
(Carvedilol)
srgivcvsxq(owydywcist) = gcxonzpswq miagqblkps (hftjpldhzu, 121.3)
Phase 3
19,102
ivabradine
bkbngxfgky(jjgtzblayj) = xjhagjlqhv qhitstyhqd (dcacoeycsn )
Negative
18 Sep 2014
Placebo
bkbngxfgky(jjgtzblayj) = fbobblnmnz qhitstyhqd (dcacoeycsn )
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Regulation

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