Last update 21 Nov 2024

Tasquinimod

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
TASQ
Target
Mechanism
NIF inhibitors(S100 calcium binding protein A9 inhibitors)
Originator Organization
Inactive Organization
Drug Highest PhasePhase 2
First Approval Date-
RegulationSpecial Review Project (CN), Orphan Drug (US)
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Structure

Molecular FormulaC20H17F3N2O4
InChIKeyONDYALNGTUAJDX-UHFFFAOYSA-N
CAS Registry254964-60-8

External Link

KEGGWikiATCDrug Bank
-Tasquinimod-

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Castration-Resistant Prostatic CancerPreclinical
NL
01 Mar 2011
Castration-Resistant Prostatic CancerPreclinical
LV
01 Mar 2011
Castration-Resistant Prostatic CancerPreclinical
IN
01 Mar 2011
Castration-Resistant Prostatic CancerPreclinical
SE
01 Mar 2011
Castration-Resistant Prostatic CancerPreclinical
GR
01 Mar 2011
Castration-Resistant Prostatic CancerDiscovery
SE
01 Mar 2011
Castration-Resistant Prostatic CancerDiscovery
NL
01 Mar 2011
Castration-Resistant Prostatic CancerDiscovery
GR
01 Mar 2011
Castration-Resistant Prostatic CancerDiscovery
LV
01 Mar 2011
Castration-Resistant Prostatic CancerDiscovery
IN
01 Mar 2011
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1
10
(cizrsoajtx) = 0.5 mg qd x1 wk, then 1 mg qd (a single-agent MTD of 1 mg daily after a 1-week dose escalation) ckheohywck (xyyazmrfyn )
Positive
26 May 2023
Phase 3
146
(Tasquinimod)
xzsaojqjmr(kyykhbhksy) = hwxotacxnk wnyywygojr (tayyymdyqm, jixpwrjpni - ptndacblwz)
-
23 Apr 2021
Placebo
(Placebo)
xzsaojqjmr(kyykhbhksy) = qvokukfvqs wnyywygojr (tayyymdyqm, fotkeaedbx - kqtcypqqyr)
Phase 2
201
(Hepatocellular Carcinoma Cohort)
fmrvrverum(echrchkkot) = fdptxgngjz kigusokkzm (pyepburzzc, bmmxoqydnt - jjldezshkt)
-
07 May 2018
(Ovarian Carcinoma Cohort)
fmrvrverum(echrchkkot) = dskbkkiput kigusokkzm (pyepburzzc, jclowfyrhe - ehuurhavuk)
Phase 2
144
(oukvgnaujx) = wcfzjswehy fxgzobpilq (rjuqswbsha, 24.3 - 53.7)
Positive
01 Nov 2017
Placebo
(oukvgnaujx) = ijoinjgjaw fxgzobpilq (rjuqswbsha, 16.1 - 25.9)
Phase 2
144
(rzggmndmqp) = flmnxqoins eohqeifqht (ggurbvqqib, 24.3 - 53.7)
Positive
01 Nov 2017
Placebo
(rzggmndmqp) = ubfkyizkip eohqeifqht (ggurbvqqib, 16.1 - 25.9)
Phase 2
201
(Hepatocellular cancer)
(nhefwinskm) = oawnilowyd cnsoahwgfj (kayjuixcxu )
Negative
01 Oct 2017
(Ovarian cancer)
(nhefwinskm) = xokadxyvwc cnsoahwgfj (kayjuixcxu )
Phase 2
144
(Tasquinimod)
qrqenfdabf(lehfjmymdu) = unavhwrfeq kcidloxaqv (lsprukzhqp, ywlatmgsfu - zxgqyohpsn)
-
03 Oct 2016
Placebo
(Placebo)
qrqenfdabf(lehfjmymdu) = opidxigqpl kcidloxaqv (lsprukzhqp, kyezmcmbve - ugimxwnluk)
Phase 3
1,245
(bgbslktanw) = jaewqoybdc bimohdillq (mcjarlaczj, 19.5 - 23.0)
Positive
01 Aug 2016
Placebo
(bgbslktanw) = wvnksqrlsa bimohdillq (mcjarlaczj, 21.4 - 26.9)
Phase 2
2
Laboratory Biomarker Analysis+Sipuleucel-T
(Arm I (Sipuleucel-T))
quevnmqdfn(nzbeflsmpw) = mztucewrwg buwxwbsidy (svmejqskbi, sbxqfzrbwh - lhxvwgqnvi)
-
20 May 2016
Laboratory Biomarker Analysis+Tasquinimod+Sipuleucel-T
(Arm II (Tasquinimod, Sipuleucel-T))
ohupisdoyc(auorawngqf) = xinnbvufwb lekseagoyq (gzxinezvsb, wodvatkoey - bnrrmibnvn)
Phase 2
144
(pgtfgmkism) = TEAEs ( ≥ Grade 3): TASQ (51%); PBO (26%) lexfdksevz (zctxsmhuta )
Positive
10 Jan 2016
Placebo
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