Last update 21 Nov 2024

Setanaxib

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
2-(2-chlorophenyl)-4-[3-(dimethylamino)phenyl]-5-methyl-1H-pyrazolo[4,3-C]pyridine-3,6(2H,5H)-dione
+ [3]
Mechanism
NOX1 inhibitors(NADPH oxidase 1 inhibitors), NOX4 inhibitors(NADPH oxidase 4 inhibitors)
Originator Organization
Inactive Organization-
Drug Highest PhasePhase 3
First Approval Date-
RegulationOrphan Drug (EU), Fast Track (US)
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Structure

Molecular FormulaC21H19ClN4O2
InChIKeyRGYQPQARIQKJKH-UHFFFAOYSA-N
CAS Registry1218942-37-0

External Link

KEGGWikiATCDrug Bank
-Setanaxib--

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Recurrent Squamous Cell Carcinoma of the Head and NeckPhase 3
SE
30 Jan 2022
Diabetes Mellitus, Type 2Discovery
AU
01 Oct 2013
Diabetes Mellitus, Type 2Discovery
CZ
01 Oct 2013
Diabetes Mellitus, Type 2Discovery
DE
01 Oct 2013
ProteinuriaDiscovery
AU
01 Oct 2013
ProteinuriaDiscovery
CA
01 Oct 2013
ProteinuriaDiscovery
DE
01 Oct 2013
ProteinuriaDiscovery
CZ
01 Oct 2013
ProteinuriaDiscovery
US
01 Oct 2013
ProteinuriaDiscovery
PL
01 Oct 2013
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
55
xhbqwxntyq(ednuxyqhiv) = ufooycoekk epgtkkwulb (xewtkosssu, 9.323)
Positive
14 Sep 2024
xhbqwxntyq(ednuxyqhiv) = ohhbcnxqgh epgtkkwulb (xewtkosssu, 8.997)
Phase 2
76
(pbqkinvkle) = Patients treated with setanaxib showed statistically significant improvements in the primary endpoint of ALP of 19% in the 1600mg arm and 14% in the 1200mg arm and showed positive trends on liver stiffness assessed by FibroScan® at 24 weeks. xlokmsnnrc (gkriamjhzy )
Met
Positive
26 Jul 2024
Placebo
Phase 2
55
(nqhzifcssj) = msxyewvyws noolwcaoyj (tbmydifzwu )
Positive
06 May 2024
Pembrolizumab + Placebo
(nqhzifcssj) = dzfyampiwi noolwcaoyj (tbmydifzwu )
Phase 2
111
(rowcjdfdml) = qglpfvqewm keirvrbjcf (hhfzownrht, 59.6)
Positive
15 May 2023
(rowcjdfdml) = xablzloihl keirvrbjcf (hhfzownrht, 28.9)
Phase 2
111
Placebo oral capsule+GKT137831
(GKT137831 400mg Once Daily)
bupvjlzske(jnlncpxzfs) = ygmrtvicyr bqvwfpvxou (ttvrqchgxy, tqrcgrgbmr - iyowjjwvua)
-
31 Mar 2022
(GKT137831 400mg Twice Daily)
bupvjlzske(jnlncpxzfs) = rgmpwthfyx bqvwfpvxou (ttvrqchgxy, zrfdqmozgr - gavyccjkrq)
Phase 2
111
(cxeszijtmh): P-Value = <0.002
Positive
24 Jun 2019
Placebo
Phase 2
Primary Biliary Cholangitis
ALP | GGT | liver transaminases ...
111
qmdgqswdws(ugxxbulbqc) = rblyfpnqqk qftwzlrtvv (japwckcxaa )
Positive
11 Apr 2019
Placebo
vmmjhggfoq(lafxpagcxi) = wsfpsqbosf xnvsdgjxyn (dtmwgytkdj )
Phase 2
155
(qmedxgmndg) = not achieved within this timeframe lpkcmggxlg (zonidyppir )
Positive
09 Sep 2015
Placebo
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Regulation

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