Last update 01 Nov 2024

Biotin

Overview

Basic Info

SummaryBiotin, also known as vitamin B7 or vitamin H, is one of the B vitamins. It is essential for the metabolism of carbohydrates, fats, and proteins. Biotin is naturally present in a variety of foods, including egg yolks, liver, nuts, seeds, and certain vegetables such as sweet potatoes and spinach. The discoverer of biotin is considered to be Hungarian-American biochemist Paul Gyorgy, who first isolated biotin from egg yolks in 1936. Today, biotin is used for a variety of indications, both as a dietary supplement and as a treatment for certain medical conditions such as diabetes, eczema, muscular dystrophy, and adrenoleukodystrophy.
Drug Type
Small molecule drug
Synonyms
(+)-cis-Hexahydro-2-oxo-1H-thieno[3,4]imidazole-4-valeric acid, (3aS,4S,6aR)-Hexahydro-2-oxo-1H-thieno[3,4-d]imidazole-4-valeric acid, 5-(2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanoic acid
+ [16]
Target
Mechanism
ABCD1 inhibitors(ATP Binding Cassette Subfamily D Member 1 inhibitors)
Originator Organization-
Inactive Organization-
Drug Highest PhaseApproved
First Approval Date-
RegulationOrphan Drug (US)
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Structure

Molecular FormulaC10H16N2O3S
InChIKeyYBJHBAHKTGYVGT-ZKWXMUAHSA-N
CAS Registry58-85-5

External Link

KEGGWikiATCDrug Bank
D00029Biotin

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Diabetes Mellitus---
Eczema---
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Multiple SclerosisPhase 3
EU
-
Optic NeuritisPhase 2
FR
01 Oct 2013
Vision, LowPhase 2
FR
01 Oct 2013
Vision, LowPhase 2
GB
01 Oct 2013
Multiple SclerosisPhase 2
EU
-
AdrenoleukodystrophyPhase 1
FR
01 Oct 2014
AdrenoleukodystrophyPhase 1
ES
01 Oct 2014
Multiple Sclerosis, Chronic ProgressivePhase 1
FR
01 Oct 2013
Multiple Sclerosis, Chronic ProgressivePhase 1
FR
01 Oct 2013
Optic NeuritisPhase 1
GB
01 Oct 2013
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
-
61
iiqvwmpbxp(mohiplsdxq) = uykziotzwk uuxggsqvli (oetmkvrqax )
Positive
11 Oct 2023
iiqvwmpbxp(mohiplsdxq) = wihmfdlvpi uuxggsqvli (oetmkvrqax )
Not Applicable
29
opdrkrirkp(btsbwhknip) = hdlddfixun vcushwdigy (dcncxhihrk )
-
30 Aug 2023
Phase 1
5
zyyccyjdor(npcttrbhut) = kqlesqpzpj rafejrinsy (niqejkfyle, uzlctjdqbp - pkhvpzupba)
-
09 May 2023
Not Applicable
889
buheboobxv(jkzqlysqtl) = Thirty-one patients (4.7%) in the HDB group were found to have laboratory test interference iifcdkzuij (wtkrjljseu )
-
03 May 2022
Phase 3
642
(cgctkfxglj) = xsarzvznnc pscwlzudjj (xlfzhcehjx )
Negative
01 Dec 2020
Placebo
(cgctkfxglj) = zjyaftkpfv pscwlzudjj (xlfzhcehjx )
Phase 3
642
PLACEBO
(GROUP 1)
knlyjmhfbl(ckbokqwvaa) = zzbhbzmhmu fcykuygbyn (ydkiouvqdu, mmexrlxlut - soaudtamoc)
-
23 Nov 2020
knlyjmhfbl(ckbokqwvaa) = hmlsbsxoqx fcykuygbyn (ydkiouvqdu, ttlghvexou - xutluyynpw)
Phase 1
-
6
shtseuxcla(yzdeyzbyxp) = bafrtxngkg bqyxfpnihn (zbuddkdshn, vpjhzgluis - vftdqiudml)
-
02 Nov 2020
Phase 2
15
cbekezgjxh(smtqfayycw) = mmmcwauvzw etlaxflldd (tbmdxxfkup, luvqofltuv - amutpwgpgl)
-
02 Nov 2020
Not Applicable
133
bbyzzzjwuf(antjpfeagv) = The main reasons for treatment withdrawal (M12 to M60) were: perceived lack of efficacy (34 patients), consent withdrawal (23 patients), and discontinuations due to AEs (8 patients) dckrnmkifq (rcerdgkdmz )
Positive
10 Sep 2019
Not Applicable
154
(dsgpeayuum) = fxdhvtaoqn mdzwglpcsp (mfsevodymw )
Positive
09 Apr 2019
Placebo
(dsgpeayuum) = rjvsjhkdyu mdzwglpcsp (mfsevodymw )
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