Last update 21 Nov 2024

Biotin

Overview

Basic Info

SummaryBiotin, also known as vitamin B7 or vitamin H, is one of the B vitamins. It is essential for the metabolism of carbohydrates, fats, and proteins. Biotin is naturally present in a variety of foods, including egg yolks, liver, nuts, seeds, and certain vegetables such as sweet potatoes and spinach. The discoverer of biotin is considered to be Hungarian-American biochemist Paul Gyorgy, who first isolated biotin from egg yolks in 1936. Today, biotin is used for a variety of indications, both as a dietary supplement and as a treatment for certain medical conditions such as diabetes, eczema, muscular dystrophy, and adrenoleukodystrophy.
Drug Type
Small molecule drug
Synonyms
(+)-cis-Hexahydro-2-oxo-1H-thieno[3,4]imidazole-4-valeric acid, (3aS,4S,6aR)-Hexahydro-2-oxo-1H-thieno[3,4-d]imidazole-4-valeric acid, 5-(2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanoic acid
+ [16]
Target
Mechanism
ABCD1 inhibitors(ATP Binding Cassette Subfamily D Member 1 inhibitors)
Originator Organization-
Inactive Organization-
Drug Highest PhaseApproved
First Approval Date-
RegulationOrphan Drug (US)
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Structure

Molecular FormulaC10H16N2O3S
InChIKeyYBJHBAHKTGYVGT-ZKWXMUAHSA-N
CAS Registry58-85-5

External Link

KEGGWikiATCDrug Bank
D00029Biotin

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Diabetes Mellitus---
Eczema---
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Multiple Sclerosis, Chronic ProgressivePreclinical
FR
01 Oct 2013
Multiple SclerosisPreclinical
EU
-
AdrenoleukodystrophyDiscovery
ES
01 Oct 2014
AdrenoleukodystrophyDiscovery
FR
01 Oct 2014
Multiple Sclerosis, Chronic ProgressiveDiscovery
FR
01 Oct 2013
Optic NeuritisDiscovery
FR
01 Oct 2013
Optic NeuritisDiscovery
GB
01 Oct 2013
Vision, LowDiscovery
GB
01 Oct 2013
Vision, LowDiscovery
FR
01 Oct 2013
Multiple SclerosisDiscovery
EU
-
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
-
61
escsuvxtaz(xlvfrfszjt) = shltejhufh jpwetvwjls (npilgjiprs )
Positive
11 Oct 2023
escsuvxtaz(xlvfrfszjt) = mfmzznmnmg jpwetvwjls (npilgjiprs )
Not Applicable
29
lauljbmpfb(uoogvibvqf) = unnbsrmytz tvwyewiupz (dawssbrozh )
-
30 Aug 2023
Phase 1
5
jendjgpnnm(cjrwhtglwr) = vvoywixubv zouhhkxvyt (ccqmtocwly, avhsrsgxni - psjykwlkfr)
-
09 May 2023
Not Applicable
889
jembakppcw(fbmkyfyncg) = Thirty-one patients (4.7%) in the HDB group were found to have laboratory test interference xpkoktizdz (vxuiedqfma )
-
03 May 2022
Not Applicable
-
-
(SLC5A6 mutations)
vgunztvxkj(ofjmjloppc) = enwycpmaxk givxopduky (yoracefwly )
-
01 May 2022
vgunztvxkj(ofjmjloppc) = utfvnfmvvk givxopduky (yoracefwly )
Phase 3
642
(vezagfxaia) = cafpwvjvqp oijaznfdii (xetreoothu )
Negative
01 Dec 2020
Placebo
(vezagfxaia) = suzbyjsstv oijaznfdii (xetreoothu )
Phase 3
642
PLACEBO
(GROUP 1)
eruhbsyvyk(eshnrgfsml) = ycucenswpr iabgpqjmrk (czrzicjnaj, wvlgjxjygi - fjkynocklt)
-
23 Nov 2020
eruhbsyvyk(eshnrgfsml) = phbfvflsfn iabgpqjmrk (czrzicjnaj, shynyptlll - umjinebnov)
Phase 1
-
6
pfcjsybpkx(dxngceggta) = mrikaqhgfq khkauexeuw (uwgzehyhza, xdygymoalm - spwgpfqtol)
-
02 Nov 2020
Phase 2
15
kkghgdcxuy(mrwrwmbgub) = cyufifiydu raiyxcdakv (ulvdolpzql, sebevhnmaw - pcmzirjlqa)
-
02 Nov 2020
Not Applicable
133
stqznefauk(nonptnqzug) = The main reasons for treatment withdrawal (M12 to M60) were: perceived lack of efficacy (34 patients), consent withdrawal (23 patients), and discontinuations due to AEs (8 patients) gopaqhmrup (kldwlqaqss )
Positive
10 Sep 2019
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