Last update 06 Jan 2025

Biotin

Last update 06 Jan 2025

Overview

R&D Status

Clinical Result

Translational Medicine

Overview

Basic Info

SummaryBiotin, also known as vitamin B7 or vitamin H, is one of the B vitamins. It is essential for the metabolism of carbohydrates, fats, and proteins. Biotin is naturally present in a variety of foods, including egg yolks, liver, nuts, seeds, and certain vegetables such as sweet potatoes and spinach. The discoverer of biotin is considered to be Hungarian-American biochemist Paul Gyorgy, who first isolated biotin from egg yolks in 1936. Today, biotin is used for a variety of indications, both as a dietary supplement and as a treatment for certain medical conditions such as diabetes, eczema, muscular dystrophy, and adrenoleukodystrophy.

Drug Type

Small molecule drug

Synonyms

(+)-cis-Hexahydro-2-oxo-1H-thieno[3,4]imidazole-4-valeric acid, (3aS,4S,6aR)-Hexahydro-2-oxo-1H-thieno[3,4-d]imidazole-4-valeric acid, 5-(2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanoic acid

+ [16]

Target

ABCD1

Mechanism

ABCD1 inhibitors(ATP Binding Cassette Subfamily D Member 1 inhibitors)

Therapeutic Areas

Endocrinology and Metabolic DiseaseSkin and Musculoskeletal DiseasesNervous System Diseases+ [2]

Active Indication

Diabetes MellitusEczemaAlzheimer Disease+ [2]

Inactive Indication

Amyotrophic Lateral SclerosisCharcot-Marie-Tooth Disease, Type IaCharcot-Marie-Tooth Disease, Type Ib+ [7]

Originator Organization-

Active Organization

Harvard Medical School

Washington & Jefferson CollegeCiberer

+ [1]

Inactive Organization

MedDay Pharmaceuticals SAS

Drug Highest PhaseApproved

First Approval Date-

RegulationOrphan Drug (US)

Structure

Molecular FormulaC10H16N2O3S

InChIKeyYBJHBAHKTGYVGT-ZKWXMUAHSA-N

CAS Registry58-85-5

Clinical Trials associated with Biotin

TCTR20240411004 / CompletedPhase 2IIT

An Experimental Study on the effect of biotin on Measurement of FT3, FT4 and TSH in healthy adults

Start Date22 Aug 2023

Sponsor / Collaborator-

CTRI/2023/07/055359 / CompletedNot Applicable

A Randomized Double-Blind Placebo-Controlled Safety and Efficacy Study of Plant Based Biotin and Plant Based Biotin with Silica in Healthy Adult Human Subjects with complaints of Hair Fall Thin Dry & Brittle Hair and Dry Skin - NIL

Start Date01 Aug 2023

Sponsor / Collaborator-

CTRI/2023/07/055057 / CompletedPhase 3

An Open Label, Prospective, Non-Comparative, Single Arm Clinical Study to Evaluate the Efficacy, Safety and Tolerability of H-Vit Hair Serum of Systopic Laboratories Pvt. Ltd. in Hair Fall Control, Hair Growth Potential and Improvement in Hair Health in Adult Volunteers - NIL

Start Date31 Jul 2023

Sponsor / Collaborator

Systopic Laboratories Private Limited

[+1]

100 Clinical Results associated with Biotin

100 Translational Medicine associated with Biotin

100 Patents (Medical) associated with Biotin

4,457

Literatures (Medical) associated with Biotin

01 Apr 2025·WATER RESEARCH

The alleviation of Cr(Ⅵ) stress on simultaneous nitrification and denitrification process of Acinetobacter haemolyticus RH19

Article

Author: Chen, Yuancai ; Shi, Yuqi ; Ma, Ruhui

Bioremediation of Cr(Ⅵ) and ammonia is considered as a promising and cost-effective alternative to chemical and physical methods. However, Cr(Ⅵ) could inhibit nitrogen removal by inhibiting intra-/extracellular electron (IET/EET) transfer or nitrifying and denitrifying enzymes activity due to its higher solubility. In this study, we isolated a simultaneous nitrification and denitrification (SND) microorganism Acinetobacter haemolyticus RH19, capable of outcompeting oxygen to take nitrogen oxides/ammonia as electron acceptors, and studied a combined accelerant (cysteine, biotin and cytokinin) to relive the Cr(Ⅵ) stress. Respiratory chain inhibited experiments and intermediates showed that strain RH19 had the intact intracellular respiratory chain. Despite the inhibited complex Ⅳ favoring the electrons transfer to NO_x^--N, the SND process was still greatly inhibited with Cr(Ⅵ), likely attributed to lower electron flow to the electron acceptors (nitration/nitrition/denitrification enzyme). Instead, the accelerant detoxified Cr(Ⅵ) mainly at CoQ site responsible for electron transfer to AMO and NAP, as well as complex Ⅳ (related with aerobic denitrification), favoring the shortcut SND (SSND, NH₄⁺-N→NH₂ON→NO₂^--N→N₂) process by directly converting nitrite to nitrogen gases. Additionally, accelerant could stimulate the secretion of c-Cyts and flavin mononucleotide (FMN) to improve the electron transfer. Overall, this study highlighted the accelerant-alleviated mechanism in the SND process under Cr(Ⅵ) stress, and deepened the theoretical SND basis for the treatment of co-existing pollutants.

01 Jan 2025·INTERNATIONAL JOURNAL OF PHARMACEUTICS

Optimising 3D printed medications for rare diseases: In-line mass uniformity testing in direct powder extrusion 3D printing

Article

Author: Couce, Maria L. ; Rial, Carlos ; Rodríguez-Pombo, Lucía ; Januskaite, Patricija ; Carou-Senra, Paola ; Goyanes, Alvaro ; Mora-Castaño, Gloria ; Caraballo, Isidoro ; Alvarez-Lorenzo, Carmen ; Couce, Maria L ; Millán-Jiménez, Mónica ; Bendicho-Lavilla, Carlos ; Basit, Abdul W ; Basit, Abdul W.

Biotinidase deficiency is a rare inherited disorder characterized by biotin metabolism issues, leading to neurological and cutaneous symptoms that can be alleviated through biotin administration. Three-dimensional (3D) printing (3DP) offers potential for personalized medicine production for rare diseases, due to its flexibility in designing dosage forms and controlling release profiles. For such point-of-care applications, rigorous quality control (QC) measures are essential to ensure precise dosing, optimal performance, and product safety, especially for low personalized doses in preclinical and clinical studies. In this work, we addressed QC challenges by integrating a precision balance into a direct powder extrusion pharmaceutical 3D printer (M3DIMAKER™) for real-time, in-line mass uniformity testing, a critical quality control step. Small and large capsule-shaped biotin printlets (3D printed tablets) for immediate- and extended-release were printed. The integrated balance monitored and registered each printlet's weight, identifying any deviations from acceptable limits. While all large printlet batches met mass uniformity criteria, some small printlet batches exhibited weight deviations. In vitro release studies showed large immediate-release printlets releasing 82% of biotin within 45 min, compared to 100% for small immediate-release printlets. For extended-release formulations, 35% of the drug was released from small printlets, whereas 24% was released from large printlets at the same time point. The integration of process analytical technology tools in 3DP shows promise in enhancing QC and scalability of personalized dosing at the point-of-care, demonstrating successful integration of a balance into a direct powder extrusion 3D printer for in-line mass uniformity testing across different sizes of capsule-shaped printlets.

01 Jan 2025·EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

The effects of ligand distribution and density on the targeting properties of dual-targeting folate/biotin Pluronic F127/Poly (lactic acid) polymersomes

Article

Author: Wang, Qing Xiao ; Li, Zi Ling ; Gong, Yan Chun ; Xiong, Xiang Yuan

Targeted drug delivery systems modified with two or more ligands were expected to have better anti-tumor ability than those with just one ligand due to the complexity and heterogeneity of tumors. Thus, dual-targeting Pluronic/poly (lactic acid) polymersomes containing biotin (BT) and folic acid (FA) ligands (BT/FA-F127-PLA) were designed to study their targeting properties over human ovarian cancer cells (OVCAR-3). Two kinds of dual-ligand targeting polymersomes, BT/FA-F127-PLA and (BT + FA)-F127-PLA, were prepared to study the effect of the dual-ligand distribution on the cell targeting of polymersomes. BT/FA-F127-PLA had two ligands distributed in the same polymersomes whereas (BT + FA)-F127-PLA had two ligands distributed in different polymersomes. The in vitro cytotoxicity and cellular uptake, and in vivo pharmacokinetic behaviors of BT/FA-F127-PLA were superior to those of (BT + FA)-F127-PLA. It suggested that biotin and folate ligands distributed on the same polymersomes could have the targeting effect of synergistic promotion. Further experiments on cell uptake mechanisms of polymersomes showed that the uptake of targeted polymersomes was associated with energy-dependent endocytosis, involving clathrin, caveolin protein, macropinocytosis and ligand receptor-mediated endocytosis. In addition, the effect of different density ratios of dual ligands for BT/FA-F127-PLA was further studied. The results showed that the cellular targeting effect of BT/FA-F127-PLA was the strongest when the molar ratio of biotin to folic acid was 7.5 %: 7.5 %. In conclusion, BT/FA-F127-PLA dual-targeting polymersomes could be good candidates as targeted drug delivery carriers.

News (Medical) associated with Biotin

17 Jun 2024

·www.sciencedaily.com

Treating the gut-brain connection with B vitamins to treat Parkinson's Disease

A study has revealed a link between gut microbiota and Parkinson's disease. The researchers discovered a decrease in bacterial genes related to the synthesis of vitamins B2 and B7. The lack of these genes was associated with reduced intestinal short-chain fatty acids and polyamines, agents that maintain the intestinal barrier and prevent the leakage of toxins into the blood that can then access the brain. Using B vitamin therapy to address these deficiencies may restore the barrier and treat Parkinson's disease. A study led by Nagoya University Graduate School of Medicine in Japan has revealed a link between gut microbiota and Parkinson's disease (PD). The researchers found a reduction in the gut bacteria of genes responsible for synthesizing the essential B vitamins B2 and B7. They also identified a relationship between the lack of these genes and low levels of agents that help maintain the integrity of the intestinal barrier. This barrier prevents toxins from entering the bloodstream, which causes the inflammation seen in PD. Their findings, published in npj Parkinson's Disease, suggest that treatment with B vitamins to address these deficiencies can be used to treat PD. PD is characterized by a variety of physical symptoms that hinder daily activities and mobility, such as shaking, slow movement, stiffness, and balance problems. While the frequency of PD may vary between different populations, it is estimated to affect approximately 1-2% of individuals aged 55 years or older. Various physiological processes are heavily influenced by the microorganisms found in the gut, which are collectively known as gut microbiota. In ideal conditions, gut microbiota produce SCFAs and polyamines, which maintain the intestinal barrier that prevents toxins entering the bloodstream. Toxins in the blood can be carried to the brain where they cause inflammation and affect neurotransmission processes that are critical for maintaining mental health. To better understand the relationship between the microbial characteristics of the gut in PD, Hiroshi Nishiwaki and Jun Ueyama from the Nagoya University Graduate School of Medicine conducted a metanalysis of stool samples from patients with PD from Japan, the United States, Germany, China, and Taiwan. They used shotgun sequencing, a technique that sequences all genetic material in a sample. This is an invaluable tool because it offers researchers a better understanding of the microbial community and genetic makeup of the sample. They observed a decrease in the bacterial genes responsible for the synthesizing of riboflavin (vitamin B2) and biotin (vitamin B7) in patients diagnosed with PD. Riboflavin and biotin, derived from both food and gut microbiota, have anti-inflammatory properties, which may counteract the neuroinflammation seen in diseases like PD. B vitamins play crucial roles in the metabolic processes that influence the production and functions of short-chain fatty acids (SCFAs) and polyamines, two agents that help maintain the integrity of the intestinal barrier, preventing toxins entering the bloodstream. An examination of fecal metabolites revealed decreases of both in patients with PD. The findings indicate a potential explanation for the progression of PD. "Deficiencies in polyamines and SCFAs could lead to thinning of the intestinal mucus layer, increasing intestinal permeability, both of which have been observed in PD," Nishiwaki explained. "This higher permeability exposes nerves to toxins, contributing to abnormal aggregation of alpha-synuclein, activating the immune cells in the brain, and leading to long-term inflammation." He added, "Supplementation therapy targeting riboflavin and biotin holds promise as a potential therapeutic avenue for alleviating PD symptoms and slowing disease progression." The results of the study highlight the importance of understanding the complex relationship among gut microbiota, metabolic pathways, and neurodegeneration. In the coming years, therapy could potentially be customized based on the unique microbiome pro each patient. By altering bacterial levels in the microbiome, doctors can potentially delay the onset of symptoms associated with diseases like PD. "We could perform gut microbiota analysis on patients or conduct fecal metabolite analysis," Nishiwaki said. "Using these findings, we could identify individuals with specific deficiencies and administer oral riboflavin and biotin supplements to those with decreased levels, potentially creating an effective treatment."

Microbial therapy

12 Mar 2024

·www.prnewswire.com

Bizz Energy Can Help Build Muscle and Boost Metabolism

The Nutrition-Filled Beverage Is Rewriting the Script When It Comes to Energy Drinks FORT LAUDERDALE, Fla., March 12, 2024 /PRNewswire/ -- Traditional energy beverages have a negative reputation for unhealthy ingredients and sugary crashes. Bizz Energy was designed to be the ultimate zero-sugar energy drink. The healthy alternative to the classic concept was developed by a team led by entrepreneur Gavin Jacono. Part of the goal with Bizz Energy is to provide a potent dose of clean, sugar-free, crashless energy. However, Jacono and his team have gone above and beyond to ensure that the nutritional elements of their formula deliver more than a punchy pick-me-up. "Part of the point with Bizz Energy has always been to be a clean energy drink option," explains Jacono. "We want health-conscious individuals to be able to use it as a way to tap energy without compromising their health in the process. But our goal from day one was much bigger than that. We wanted a drink that could enhance performance on a nutritional level. We wanted something that brought together the ideas of an energy drink and a supplement." The first step in achieving this was to avoid classic sweet tooth ingredients, like sugar, high fructose corn syrup, and even aspartame. In addition, the group avoided any harmful chemicals or additives. When it came to the energy part of the process, the R&D team managed to create a unique form of soluble Turkesterone. The natural ecdysteroid has a reputation for stimulating physical and mental energy. This works alongside a punchy per-can dose of 200mg of caffeine anhydrous. Jacono's team also looked for ingredients that could provide a net nutritional positive to the consumer. They included ingredients like creatine and essential amino acids to help with muscle growth and protein synthesis. They also included Niacin and Biotin to support an active metabolism. In the end, the Bizz Energy formula is much more than an average energy drink — or even an improved one. It functions as a dual energy booster and supplement. It can supercharge the mind, energize the body, improve physical performance, and enhance whatever mental or physical activity an individual is attempting to accomplish. Bizz Energy is a refreshing new take on a classic concept. It is a clean, crashless, and nutritious energy drink built to help people reach their goals and go the distance. A bout Bizz Energy Bizz Energy was founded by Gavin Jacono. The fitness and nutrition fanatic hails from New York City and is obsessed with boxing, weightlifting, and soccer. As an aspiring 17-year-old entrepreneur, Jacono launched Bizz Energy as a way to create the ultimate energy drink he had always wanted to fuel his athletic pursuits. Along with a potent dose of caffeine, the Bizz Energy formula taps into a unique form of soluble Turkesterone. It is delicious, clean, and effective. Learn more at bizzenergy.com. Contact: Gavin Jacono 516-637-8701 374108@email4pr.com SOURCE Bizz Energy

20 Nov 2023

·www.prnewswire.com

Designs for Health Launches Two Collagen Formulas, Whole Beauty Collagen™ & Collagen + MCT

Leading supplement brand now offers three unique researched-back collagen products PALM COAST, Fla., Nov. 20, 2023 /PRNewswire/ -- Designs for Health, the expert-recommended and preferred brand for high-quality, professional strength, research-backed supplements, and recipient of the 2023 Top Supplement Manufacturing Company award ** today announced the launch of Whole Beauty Collagen™ and Collagen + MCT. These products complement the company's bestselling Whole Body Collagen, now offering consumers three superior, efficacious collagen formulas. Whole Beauty Collagen™ is a convenient once-daily powder featuring hydrolyzed collagen peptides and Lustriva®, a patented, clinically researched blend of stabilized biotin and silica, to provide comprehensive support for hair, skin, and nails.* Evidence suggests that Lustriva® may help promote hair fullness, optimal skin texture, and nail strength.* Additionally, the magnesium biotinate used in this formula may have 40 times greater dissolvability and absorption than the biotin used in common beauty products. Collagen + MCT is a keto-friendly powder featuring hydrolyzed collagen peptides from grass-fed, pasture-raised bovine sources and medium-chain triglycerides (C8 & C10 MCTs) from highly refined coconut oil. MCTs metabolize differently than other fats; the body converts them into ketones, even when not on a ketogenic diet, and provide a quick source of energy that most cells and tissues can use. They are especially known for fueling the brain, heart, and skeletal muscles. Research also suggests that MCTs may provide fuel for brain cells, helping to support cognitive function and mental clarity.* Whole Body Collagen is a synergistic formulation designed to benefit the health of bones, joints, and skin.* It contains the research-backed collagen peptide blends Verisol®, Fortigel®, and Fortibone® derived from specific dietary collagen proteins and produced with proprietary hydrolyzation technologies to optimize their beneficial properties. This unique blend is supported by clinical research showing its efficacy for collagen production, bone strength, joint health and integrity, and skin elasticity.* "While the market for collagen supplements has skyrocketed in recent years, all collagen products are not created equal, which is why we are proud to offer three high-quality research-backed formulations that consumers and practitioners can trust," said Chief Medical Officer, Dr. David M. Brady at Designs for Health. "Collagen makes up roughly 30% of the body's protein and 75% of the skin's structure; however, we start to produce less of it as we age, making supplementation vital to helping the body rebuild the collagen that it depends on. Our three unique SKUs have been carefully formulated to provide adults with an easy and convenient way to incorporate specific molecular weight clinically studied collagen into their daily wellness routines at any age." Designs for Health began in 1989 as a small educational services company with deep roots in natural medicine – and big ambitions to revolutionize the industry. More than 30 years later, the company is pioneering new approaches to nutritional science, breaking barriers in quality standards, and ultimately transforming the healthcare ecosystem. Through a robust product pipeline and a diverse portfolio of more than 300 nutritional products, Designs for Health is leading the charge in the natural and integrative medicine movement to design a well world for all. Whole Beauty Collagen, Collagen + MCT, and Whole Body Collagen are unflavored and unsweetened, making them easy to add to any beverage or shake. They are gluten-free, dairy-free, soy-free, and non-GMO, and available to purchase at . To learn more about Designs for Health and its comprehensive portfolio of products, including its line of oral health products, visit . Please tune in to Designs for Health's new podcast, Conversations for Health, and immerse yourself in the current landscape of Functional Medicine to empower you to design a well world with us. About Designs for Health, Inc. Family-owned Designs for Health, Inc. offers high-quality dietary supplements and functional foods to healthcare professionals and their patients. Guided by its founding philosophy of "Science-First™," the company holds an unwavering commitment to creating research-driven formulations with meaningful quantities of functional ingredients that maximize the potential for successful health outcomes. For over 30 years, Designs for Health has been many healthcare professionals' trusted source for not only product innovation but also leadership in clinical education and practice development solutions. **Awarded by Food Business Review *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Contact: 5WPR 212-999-5585 [email protected] SOURCE Designs for Health

100 Deals associated with Biotin

External Link

KEGG	Wiki	ATC	Drug Bank
D00029	Biotin	A11HA05	DB00121

R&D Status

Approved

10 top approved records.

to view more data

Indication	Country/Location	Organization	Date
Diabetes Mellitus	-	-	-
Eczema	-	-	-

Developing

10 top R&D records.

to view more data

Indication	Highest Phase	Country/Location	Organization	Date
Multiple Sclerosis	NDA/BLA	EU	MedDay Pharmaceuticals SAS	-
Adrenoleukodystrophy	Phase 3	FR	MedDay Pharmaceuticals SAS	01 Oct 2014
Adrenoleukodystrophy	Phase 3	DE	MedDay Pharmaceuticals SAS	01 Oct 2014
Adrenoleukodystrophy	Phase 3	ES	MedDay Pharmaceuticals SAS	01 Oct 2014
Multiple Sclerosis, Chronic Progressive	Phase 3	FR	MedDay Pharmaceuticals SAS	01 Oct 2013
Optic Neuritis	Phase 3	FR	MedDay Pharmaceuticals SAS	01 Oct 2013
Optic Neuritis	Phase 3	GB	MedDay Pharmaceuticals SAS	01 Oct 2013
Vision, Low	Phase 3	FR	MedDay Pharmaceuticals SAS	01 Oct 2013
Vision, Low	Phase 3	GB	MedDay Pharmaceuticals SAS	01 Oct 2013
Charcot-Marie-Tooth Disease, Type Ia	Phase 2	FR	MedDay Pharmaceuticals SAS	05 Dec 2016

Clinical Result

Indication

Phase

Evaluation

View All Results

Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


ENDO2024	Not Applicable	Hyperandrogenism	-	Biotin	rkhmeqonqc(arjoejyeah) = lavbsckgfo ksztvgprbd (lbycoieton ) View more	-	01 Jun 2024
EADV2023	Not Applicable	-	61	Oral biotin	gugnavwekv(imtbcutbbe) = sbhnzftkwf qbneahykxi (ctfbzbvgys ) View more	Positive	11 Oct 2023
EADV2023	Not Applicable	-	61	Pyridoxine	gugnavwekv(imtbcutbbe) = cfqutfytls qbneahykxi (ctfbzbvgys ) View more	Positive	11 Oct 2023
SSIEM2023	Not Applicable	Congenital Disorders of Glycosylation biotinidase activity	29	biotin	ojwrpikbcn(bufxhmtlti) = znzthwkmqq riqabcevnc (rdipygmzzn )	-	30 Aug 2023
NCT02757898 (b-RBCs, CTgov)	Phase 1	Anemia	5	Biotin-Labeled Red Blood Cells (RBCs)	ycyqiuuobd(bwwyvgxcyi) = skazyvbxfq uuowazwowf (isudrftvqg, pmwacfmbhd - axlckufotk) View more	-	09 May 2023
PMON224 (ENDO2022)	Not Applicable	postmenopausal disorder	-	Biotin	votiososnl(gxnfcpauww) = oktayxlhxm kvwbiosiko (nypwjuibub )	-	01 Nov 2022
AAN2022	Not Applicable	Multiple Sclerosis	889	High-dose biotin (HDB)	canzlyycfo(fhlitsoant) = Thirty-one patients (4.7%) in the HDB group were found to have laboratory test interference jwonehjocp (bfkvgkrlww )	-	03 May 2022
AAI2022	Not Applicable	-	-	Biotin (SLC5A6 mutations)	gquwztbapw(enwruylhpu) = qsadmihepn hayorbgktn (ljeayjnrgf ) View more	-	01 May 2022
AAI2022	Not Applicable	-	-	Biotin replenishment	gquwztbapw(enwruylhpu) = ghbysropbr hayorbgktn (ljeayjnrgf ) View more	-	01 May 2022
ENDO2021	Not Applicable	Adrenal Insufficiency ACTH \| morning cortisol \| DHEA-S	-	Hydrocortisone therapy	adfoweixme(hudvjdndnt) = fvprbldbdz qeregtnqmk (egzpzrgbss, 7.2–63.3)	-	03 May 2021
NCT02936037 (SPI2, Pubmed) Manual	Phase 3	Multiple Sclerosis, Chronic Progressive	642	MD1003	uulhtbtjzk(hicthiwweu) = yfgcokcyfv yoasmcvmkr (koaxftaswx ) View more	Negative	01 Dec 2020
NCT02936037 (SPI2, Pubmed) Manual	Phase 3	Multiple Sclerosis, Chronic Progressive	642	Placebo	uulhtbtjzk(hicthiwweu) = vdyltvdxwx yoasmcvmkr (koaxftaswx ) View more	Negative	01 Dec 2020
NCT02936037 (SPI2, CTgov)	Phase 3	Multiple Sclerosis, Chronic Progressive	642	PLACEBO (GROUP 1)	xoidbtsipq(mfxncjannq) = nuohuluyno mmaydhldsl (alckkpnbob, jjvnwdutgq - rswbngndcy) View more	-	23 Nov 2020
NCT02936037 (SPI2, CTgov)	Phase 3	Multiple Sclerosis, Chronic Progressive	642	MD1003 100mg capsule (GROUP 2)	xoidbtsipq(mfxncjannq) = tkgudxltqq mmaydhldsl (alckkpnbob, szinkdingx - qyrxqsoqcw) View more	-	23 Nov 2020

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