Last update 11 Jul 2024

Sigvotatug vedotin

Overview

Basic Info

Drug Type
Antibody drug conjugate (ADC)
Synonyms
humanized immunoglobulin G1 anti-integrin beta-6 monoclonal antibody conjugated to monomethyl auristatin E
+ [3]
Target
Mechanism
ITGB6 inhibitors(integrin subunit beta 6 inhibitors)
Inactive Indication-
Originator Organization
Active Organization
Inactive Organization-
Drug Highest PhasePhase 3
First Approval Date-
RegulationOrphan Drug (US)

Structure

Molecular FormulaC11H22N4O4
InChIKeyAGGWFDNPHKLBBV-YUMQZZPRSA-N
CAS Registry159858-33-0
View All Structures (2)
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Non-Small Cell Lung CancerPhase 3
NO
21 Feb 2024
Non-Small Cell Lung CancerPhase 3
GR
21 Feb 2024
Non-Small Cell Lung CancerPhase 3
IT
21 Feb 2024
Non-Small Cell Lung CancerPhase 3
DE
21 Feb 2024
Non-Small Cell Lung CancerPhase 3
HU
21 Feb 2024
Non-Small Cell Lung CancerPhase 3
CZ
21 Feb 2024
Non-Small Cell Lung CancerPhase 3
BE
21 Feb 2024
Non-Small Cell Lung CancerPhase 3
FR
21 Feb 2024
Non-Small Cell Lung CancerPhase 3
CA
21 Feb 2024
Non-Small Cell Lung CancerPhase 3
PL
21 Feb 2024
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1
Non-Small Cell Lung Cancer
Integrin beta-6 (IB6)
113
(tbxcnsnlhx) = paldcfwxnz dbxulrhkxr (zfaaqquhao, 12.6-28.0)
Positive
24 May 2024
(1.8 mg/kg AiBW)
(tbxcnsnlhx) = alltpabdeo dbxulrhkxr (zfaaqquhao, 8.6-42.3)
Phase 1
148
(vsiijxconp) = lmfslsohbz mdnjppzrnu (ployuvpwiv )
Positive
26 May 2023
(NSCLC)
(ewzduhvqwc) = hudqabbdia jtnvtqmbjp (xdfytyflcb )
Phase 1
48
(Q1W)
(lvvsceiohs) = puwuszhvbk pbijvlrusi (uetrawkthu )
Positive
01 Nov 2022
(2Q3W)
(lvvsceiohs) = ieueozqyry pbijvlrusi (uetrawkthu )
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Translational Medicine

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Deal

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Core Patent

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Clinical Trial

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Approval

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Regulation

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