Two-thirds of the US population, particularly African Americans (AA), is at risk for inadequate or deficient 25-hydroxy-vitamin D (25(OH)VD). Epidemiological studies demonstrate an association between better health outcomes and higher blood levels of 25(OH)VD . Randomized controlled clinical trials have shown that, while supraphysiological high doses of VD are needed to achieve adequate blood levels of 25(OH)VD, not all subjects respond to them. Recent studies have also questioned the therapeutic effects of high-dose VD supplementation. Severe VD deficiency has been associated independently with the future risk of mild cognitive impairment (MCI) and dementia. A reduction in GSH and an increase in the oxidative stress levels of serum, erythrocytes, and circulating lymphocytes has been observed in MCI and Alzheimer disease, findings similar to those in VD deficient persons. Scholarly reviews conclude that excess oxidative stress is one of the major risk factors for AD and support a potential therapeutic role for L-cysteine (LC, a GSH precursor) and vitamin D (VD) supplementation in the treatment of Alzheimer disease symptoms. This application presents the investigators' design for a randomized, double-blind, placebo-controlled clinical trial to test the hypothesis that supplementation with VD in combination with L-cysteine (LC) is more successful at optimizing the statuses of 25(OH)VD [biological signatures] and simultaneously decreasing TNF-α, IR [functional or clinical outcomes], and oxidative stress, suggesting a better therapeutic approach compared with supplementation with VD alone in AA subjects.

Start Date06 Nov 2020

Sponsor / Collaborator

LSU Health Sciences Center

ChiCTR2000032022 / RecruitingEarly Phase 1IIT

Effect of perioperative nebulized inhalation of budesonide and L-Cysteine on pulmonary complications in patients with tumors of the Posterior Skull Base

Start Date30 Apr 2020

Sponsor / Collaborator-

100 Clinical Results associated with L-Cysteine

100 Translational Medicine associated with L-Cysteine

100 Patents (Medical) associated with L-Cysteine

3,592

Literatures (Medical) associated with L-Cysteine

01 Mar 2025·NEUROPHARMACOLOGY

Functional evidence that S-nitroso-L-cysteine may be a candidate carotid body neurotransmitter

Article

Author: Coffee, Gregory A ; Lewis, Stephen J ; Baby, Santhosh M. ; Bates, James N ; Seckler, James M. ; Coffee, Gregory A. ; Baby, Santhosh M ; Seckler, James M ; Palmer, Lisa A ; Getsy, Paulina M ; Lewis, Stephen J. ; Bates, James N. ; Getsy, Paulina M. ; Palmer, Lisa A.

The primary objective of the present study is to provide further evidence that the endogenous S-nitrosothiol, S-nitroso-L-cysteine (L-CSNO), plays an essential role in signaling the hypoxic ventilatory response (HVR) in rodents. Key findings were that (1) injection of L-CSNO (50 nmol/kg, IV) caused a pronounced increase in frequency of breathing (Freq), tidal volume (TV) and minute ventilation (MV) in naïve C57BL/6 mice, whereas injection of D-CSNO (50 nmol/kg, IV) elicited minimal responses; (2) L-CSNO elicited minor responses in (a) C57BL/6 mice with bilateral carotid sinus nerve transection (CSNX), (b) C57BL/6 mice treated neonatally with capsaicin (CAP) to eliminate small-diameter C-fibers, and (c) C57BL/6 mice receiving continuous infusion of L-CSNO receptor antagonists, S-methyl-L-cysteine and S-ethyl-L-cysteine (L-SMC + L-SEC, both at 5 μmol/kg/min, IV); and (3) injection of S-nitroso-L-glutathione (L-GSNO, 50 nmol/kg, IV) elicited pronounced ventilatory responses that were not inhibited by L-SMC + L-SEC. Subsequent exposure of naïve C57BL/6 mice to a hypoxic gas challenge (HXC; 10% O₂, 90% N₂) elicited pronounced increases in Freq, TV and MV that were subject to roll-off. These HXC responses were markedly reduced in CSNX, CAP, and L-SMC + L-SEC-infused C57BL/6 mice. Subsequent exposure of all C57BL/6 mice (naïve, CSNX, CAP, and L-SMC + L-SEC) to a hypercapnic gas challenge (5% CO₂, 21% O₂, 74% N₂) elicited similar robust increases in Freq, TV and MV. Taken together, these findings provide evidence that an endogenous factor with pharmacodynamic properties similar to those of L-CSNO, rather than L-GSNO, mediates the HVR in male C57BL/6 mice.

01 Feb 2025·FOOD CHEMISTRY

Smartphone-integrated inkjet-printed paper sensor and UV/Vis spectrophotometric method for on-site detection of As3+ and L-cysteine in food samples using novel AMTPP-functionalized silver nanoparticles

Article

Author: Arif, Shan ; Hussain, Kashif ; Yasmeen, Kousar ; Muhammad, Haji ; Rasheed, Sufian ; Umar, Abdul Rehman ; Anwar, Syeda Bushra ; Tuzen, Mustafa ; Shah, Muhammad Raza

The increasing prevalence of arsenic (As³⁺) in water and its health impacts necessitate advanced detection methods. Similarly, monitoring L-Cysteine, a vital thiol-containing amino acid, is crucial for assessing physiological processes and disorders. This study presents a novel method for detecting As³⁺ and L-Cysteine in food samples using 4-amino-3-(D-galactopentitol-1-yl)-5-mercapto-1,2,4-triazole (AMTPP) functionalized silver nanoparticles (AMTPP-AgNPs) by UV/Vis spectrophotometric method and smartphone-assisted inkjet-printed paper-based sensors. AMTPP-AgNPs, synthesized through a detailed process, show exceptional selectivity and sensitivity to As³⁺ and L-Cysteine, undisturbed by other metal ions and amino acids. Characterization techniques like FTIR, DLS, Zeta Potential, AFM, and SEM detailed their morphological and interaction properties. Optimizing detection parameters, such as response time, pH, and temperature, improved sensitivity and achieved low detection limits. The limits of detection (LODs) were 0.0052 μM for L-cysteine and 0.0092 μM for As³⁺, as calculated using UV-Vis spectrophotometric methods. The method also demonstrated high recovery rates in spiked meat and corn samples. This research offers a cost-effective, rapid method for on-site food analysis, significantly aiding environmental and public health monitoring.

01 Feb 2025·SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY

A Multimode fluorescent sensor for sequential detection of Cu2+ and cysteine as well as pH sensor with real sample Applications: Extensive experimental and DFT studies

Article

Author: Rauf, Waqar ; Ali Khan, Zulfiqar ; Shabbir, Alam ; Shahzad, Sohail Anjum ; Yahya Abdullah Alzahrani, Abdullah ; Yar, Muhammad ; Anjum Shahzad, Sohail ; Alzahrani, Abdullah Yahya Abdullah ; Khan, Zulfiqar Ali

Highly responsive and optically selective (E)-1-((4-phenoxyphenyl) diazenyl)naphthalen-2-ol) sensor PDN with aggregation induced emission enhancement (AIEE) properties has been developed for the sequential detection of Cu²⁺ and L- Cysteine through fluorescence On-Off-On strategy. The selectivity of sensor depends on the presence of a diazo functional group and its appropriate cavity location in sensor molecule. Azo dye-based (E)-1-((4-phenoxyphenyl) diazenyl)naphthalen-2-ol) sensor PDN has been synthesized by utilizing a simple diazotization synthetic methodology that showed extraordinary AIEE behavior with bathochromic shift owing to the formation of J-aggregates. The morphology and size of aggregates were analyzed by SEM and DLS analysis, respectively. The calculated LOD of sensor PDN for Cu²⁺, and L-cysteine is 0.113 nM, and 84 nM, respectively. Fluorescence, UV-visible, LC-MS, ¹H and ¹³C NMR titration were carried out to understand the interaction of sensor with Cu²⁺. The sensor was practically utilized in the sequential sensing of Cu²⁺ and Cys in real samples. Interestingly, sensor PDN was successfully employed for the sensing of a strong acid and base as well as the detection of Cu²⁺ ions in the solid state. Moreover, these experimental results were supported through DFT calculations.

News (Medical) associated with L-Cysteine

23 Jan 2021

·www.globenewswire.com

Zenith Lab’s Hair Revital X – Do This Supplement Ingredients Really Effective? Hair Revital X Reviews by Nuvectramedical

McHenry, IL, Jan. 23, 2021 (GLOBE NEWSWIRE) -- A frustrating problem that both men and women face over the age of 40 is hair fall. The most important feature of your body is your hair. It makes you look more beautiful and is also a factor that gives you confidence about yourself. Already Planned to Order? Click Here to Buy Hair Revital X Supplement Won't you feel completely lost if you start losing your hair? Each morning when you wake up from the bed, how would you feel when you see your hair all over the pillow? Or right after taking a shower, your hair getting clogged on the shower sink? Nothing could be more devastating than seeing your own hair shedding in front of your eyes. It becomes more painful if you're not able to find the right solution for it. But not to worry anymore! This never-ending problem of yours has now got an incredible solution. Hair Revital X is going to be your hair growth remedy that you can completely trust on. It activates the growth factors of your hair and stops further hair fall so that you will not be losing any more of your valuable hair. Know About the Hair Revital X Hair Revital X is an extraordinary combination of a dietary supplement and a topical solution that is specially made to address the most common and unavoidable problem which is hair fall. None of the hair fall control shampoos provides a permanent solution to your hair fall problem. They only make you spend nearly $60 a month. But all you end up having is the same hair fall problem and a complete loss of the money that you invested on the shampoo. But Hair Revital X stands apart from this. The natural substances present in it, destroys all the factors that are stopping your hair growth and makes your hair grow from the root. This concentrates both on hair growth and hair fall control. You no longer need to worry about your hair fall issue or try out shampoos and hair transplant treatments. Hair transplantation is only going to take your problem forward. Hair Revital X is going to take care of every strand of your hair that you will witness a positive result and a huge difference where you will see that your hair has grown better than before. Without causing any side effects Hair Revital X is going to give you back each and every single hair that you've lost and even much more than what you've lost! How Does Hair Revital X Work? Hair Revital X is formulated with a blend of natural ingredients to accelerate and maximise the hair growth in different ways like counteracting that short genetic straw and boost reducing DHT level and get free from follicles. You can get an opportunity to increase the number of follicle cells to make you feel younger and also stop damaging your follicles to stimulate better hair growth directly. Hair Revital X ingredients will quickly reduce the DHT levels to maintain in right level for stimulating hair growth and retrieves your lost hair back during the right time. Hair Revital X can realise the benefit of using blends to protect and regrow new hair by balancing DHT and Follicles to maximise the natural Hair Growth Cycle rapidly. The given regrowth extender blend is clinically tested and shortens your follicles “Shed” stage and expands the “regrowth” stage to experience better results. Read Full List of Hair Revital X Ingredients and Side Effects Before You Buy What Will You Get from Hair Revital X? By using Hair Revital X, you can improve the hair follicle cycle to start growing new healthy hair again by spending 17 hours per day in the regrowth stage for having a faster result. Once you start following Hair Revital X formulation in your daily life, it supports for healthy and shimmering hair to keep your hair young, hydrated and healthy forever. Here it supports for healthy nail, kin, and hair tissue by keeping healthy hair cell with water and oxygen to get better results on stronger hair growth, less breaking and less greying. Hair Revital X helps to lengthen your hair follicles, balance your DHT, regrowth stage and start to keep nourishing your hair cells to get healthy hair growth as much as faster. The oral capsule provides an internal tool for solving problems in the body, and topical solutions target issues directly through the skin. What Formulates the Hair Revital X? We need to know the origin of this problem before getting to know the perfect solution. Your body has a hormone called Dihydrotestosterone (DTH). It is a natural hormone that carries messages between the organs. It is responsible for a lot of growth during puberty. As you reach adulthood, their growth becomes considerably less. But when your body produces too much DTH, you experience hair fall. Every hair generally stays for a period of 4 years after which it sheds itself completely and grows again. When there is a wild growth of DTH in your body, it sends signals to your follicles and tells them to stop regrowing. As a result, many follicles get stuck at the shedding stage without reaching the regrowing stage which is why you end up losing a huge chunk of hair regularly. And this DTH imbalance could partly be a genetic reason. Hair Revital X can be stopped by what we call as DTH inhibitors. They reduce the growth of DTH. It matches the DTH hormones and makes the DTH hormones think that they have already delivered a message to the follicles. As your follicles aren't receiving any messages to stop regrowing, they automatically start growing and they get used to the normal cycle of growing, shedding and regrowing. The Hair Revital X is that DTH inhibitor that is going to help you regrow your hair. It has got the most powerful natural hair growth plant called Saw Palmetto which is said to be one of the most powerful DTH inhibitors. This can ensure that your hair stops falling and you end up getting back nothing but thick and long hair. The Hair Revital X comes up with a dietary supplement and a topical solution and now I'm about to share with you the essential natural ingredients that make up t Hair Revital X amazing hair fall rescue solution. The oral Hair Revital X supplement has got three ingredient blends. The Anti- Genetics Blend They concentrate on reducing the genetic reasons that increase the DTH growth. It has got, Nettle Leaf Extract Pygeum Bark Extract (the bark of African cherry tree ) L- Methionine (an essential amino acid that is found in your body ) The Regrowth Extender Blend Its main goal is to shorten each follicle's shed stage and increase their regrowth stage. It consists of four main ingredients Vitamin A Palmitate Phytosterols (a component from sunflower) Vitamin B5 Zinc The Healthy Hair Blend This blend supports the growth of healthy shinning hair. It is made up of four main ingredients. L- Cysteine & Vitamin B6 (they keep the hair hydrated and healthy) Folic Acid and Biotin (they produce stronger hair and supports less breaking and less greying of your hair) Together the dietary supplement of the Hair Revital X reduces the DTH growth and improves the life and growth of each hair. Likewise, the topical solution has got four ingredient blends. Anti- Genetics It has got three main ingredients. Saw Palmetto Rosemary Extract & Carthamus Thistle Extract Regrowth Extender It has got two natural ingredients. Apigenin (a component found in parsley and chamomile) Centella (a plant also called as Asian Pennywort) Healthy Hair The two ingredients that are present in this blend are, Biotinoyl Tri-Peptide 1 Panax The additional blend that's there on the topical solution is the Deep Absorption Blend. It has got three main ingredients which are, Butylene Glycol Lecithin (comes from egg yolks, sunflower seeds and soybeans) Capsaicin (comes from red pepper) These three massages your scalp from the root and helps your follicles absorb the solution. Lowest Price Guaranteed – Get Hair Revital X Supplement for The Most Discounted Price Online Known Benefits of Using Hair Revital X Hair Revital X nourishes your hair from the root. Hair Revital X can make your hair 184% denser than before. Hair Revital X reduces the DTH growth which is the main cause for your hair fall problem. Hair Revital X can give you younger looking hair. Hair Revital X comes with no side effects. All you are going to get is healthier looking thick hair. Say goodbye to your hair fall problem. Hair Revital X decreases the shedding stage of your follicles and increases the regrowing stage. How to Get the Hair Revital X? You can get this incredible solution to hair fall at an affordable cost. 30- day supply for Hair Revital X $49; 90- day supply for Hair Revital X $117 6-month supply for Hair Revital X $198 Each of which comes with a 180-day Money- Back Guarantee where you can get a refund if you're not satisfied with the product. Who should not use Hair Revital X? If you are under 18 or pregnant, you better avoid taking dietary supplements generally! It is always a good idea to consult your doctor before taking any supplement. FDA and Supplements: The FDA will never approve a dietary supplement. According to the Food and Drug Administration, dietary supplements are a category of their own, and they are not subject to FDA regulation or approval. If a company is claiming that the FDA approves their diet supplement, run. This is a clear misrepresentation. These statements have not been evaluated by the Food and Drug Administration. Hair Revital X product is not intended to diagnose, treat, cure, or prevent any disease. Conclusion – Hair Revital X Reviews Your hair fall problem is going to be long gone. With Hair Revital X all you're going to have is younger looking healthy hair that is going to boost your inner confidence like never before. Throw away those expensive shampoos that are going to cost you your hair as well as your money. Super looking thicker hair isn't too far away from you anymore. Hair Revital X promises you your every single lost hair and you're going to see the amazingly improved hair for yourself once you start using it. Visit the Official Hair Revital X Here for Huge Discount Pricing Media Contact: Zenith Labs 4610 Prime Parkway McHenry, IL, 60050, USA Email: support@tryzenith.co Phone: +1 (800) 928-1184 This product review is for informational purposes only. The information does not constitute advice or an offer to buy. Any purchase made from this story is made at your own risk. Consult an expert advisor/health professional before any such purchase. Any purchase made from this link is subject to the final terms and conditions of the website selling the product. The content on this release does not take any responsibility directly or indirectly. Contact Nuvectramedical at vijai@nuvectramedical.com This news has been published for the above source. 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IN NO EVENT SHALL KISS PR BE LIABLE OR RESPONSIBLE TO YOU OR ANY OTHER PERSON FOR ANY DIRECT, INDIRECT, INCIDENTAL, CONSEQUENTIAL, SPECIAL, OR EXEMPLARY DAMAGES OF ANY KIND, INCLUDING WITHOUT LIMITATION, LOST PROFITS OR LOST OPPORTUNITIES, EVEN IF ADVISED OF THE POSSIBILITY OF SUCH DAMAGES IN ADVANCE AND REGARDLESS OF THE CAUSE OF ACTION UPON WHICH ANY SUCH CLAIM IS BASED, INCLUDING, WITHOUT LIMITATION, ANY CLAIM ARISING OUT OF OR IN CONNECTION WITH ANY OF THE CONTENT, INCLUDING, WITHOUT LIMITATION, AUDIO, PHOTOGRAPHS, AND VIDEOS, OF OR THE ACCURACY OF ANY STATEMENT MADE IN OR OMITTED FROM ANY ADVERTISEMENT, SPONSORSHIP, ENDORSEMENT, TESTIMONIAL, OPINION, OR OTHER PRODUCT-RELATED OR SERVICE-RELATED STATEMENT OR REVIEW APPEARING IN THE WEBSITES OR IN ANY POST OR ARTICLE DISTRIBUTED VIA THE WEBSITES. © 2021 KissPR.com LLC Media Contact Website: [KISS PR Brand Story PressWire] - Email: Media@kisspr.com Attachment Zenith Lab’s Hair Revital X – Do This Supplement Ingredients Really Effective? Hair Revital X Reviews by Nuvectramedical

100 Deals associated with L-Cysteine

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Indication	Country/Location	Organization	Date
Acne Vulgaris	JP	Hisamitsu Pharmaceutical Co., Inc.	23 May 1987
Drug Eruptions	JP	Hisamitsu Pharmaceutical Co., Inc.	23 May 1987
Eczema	JP	Hisamitsu Pharmaceutical Co., Inc.	23 May 1987
Erythema exudativum	JP	Hisamitsu Pharmaceutical Co., Inc.	23 May 1987
Leukopenia	JP	Hisamitsu Pharmaceutical Co., Inc.	23 May 1987
Urticaria	JP	Hisamitsu Pharmaceutical Co., Inc.	23 May 1987

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ARVO2006	Not Applicable	-	100	Cistein (Group 1)	paouysqmgs(ldmtafnktq) = okhsaugisd qtmfsdjqgw (lplxpyflqb ) View more	Positive	01 May 2006
				Cistein (Group 2)	paouysqmgs(ldmtafnktq) = ttrqmqudqv qtmfsdjqgw (lplxpyflqb ) View more

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