Last update 19 Aug 2025

Capsaicin

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Capsaicin (JAN/USP), trans-capsaicin, 辣椒素
+ [7]
Action
inhibitors, agonists
Mechanism
PRDX2 inhibitors(peroxiredoxin 2 inhibitors), TRPV1 agonists(Transient receptor potential cation channel subfamily V member 1 agonists)
Originator Organization
License Organization
Drug Highest PhaseApproved
First Approval Date
China (24 Jan 2003),
RegulationFast Track (United States), Orphan Drug (United States)
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Structure/Sequence

Molecular FormulaC18H27NO3
InChIKeyYKPUWZUDDOIDPM-SOFGYWHQSA-N
CAS Registry404-86-4

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Diabetic peripheral neuropathic pain
United States
17 Jul 2020
Neuralgia, Postherpetic
United States
16 Nov 2009
Neuralgia
China
24 Jan 2003
Pain
China
24 Jan 2003
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Peripheral Nervous System DiseasesPhase 3
France
20 Oct 2023
Sensory neuropathyPhase 3
France
20 Oct 2023
Pain, PostoperativePhase 3
United States
13 Jul 2021
Pain, PostoperativePhase 3
France
13 Jul 2021
Pain, PostoperativePhase 3
Netherlands
13 Jul 2021
Pain, PostoperativePhase 3
Poland
13 Jul 2021
Pain, PostoperativePhase 3
Spain
13 Jul 2021
Pain, PostoperativePhase 3
United Kingdom
13 Jul 2021
Breast CancerPhase 3
France
19 Mar 2019
Nerve injuryPhase 3
Belgium
01 Nov 2011
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
58
Functional Brain Imaging+Capsaicin+Adenosine Triphosphate
(Chronic Cough Participant)
teobocotgx(uwcouhtcrz) = qonubtwbts qtkejlryyf (utvfwtyiuc, 0.60)
-
22 Aug 2024
Functional Brain Imaging+Capsaicin+Adenosine Triphosphate
(Healthy Control Participant)
teobocotgx(uwcouhtcrz) = xmtkysbgqt qtkejlryyf (utvfwtyiuc, 0.47)
Phase 3
160
beuypmanip(ympvqsrryq) = qcjhxbgxoo fmngxzzteo (oemwlqhlpd )
Positive
01 Jun 2024
Placebo
gxgfveobeo(flbwicqqbt) = obducmdlvk mkajwlrxyj (mcucrvqshy )
Phase 4
12
Hot environment+Capsaicin
(Capsaicin Gel Application)
avhdwgiugq(lknmbnnhbq) = bwrzmkoemc pmzzazprby (lykvmqmsee, 104.9)
-
15 Mar 2024
Control Gel
(Hypoallergenic Gel Application)
avhdwgiugq(lknmbnnhbq) = ygqnxkscva pmzzazprby (lykvmqmsee, 56.7)
Early Phase 1
19
uwblcnubmx(gjxuutiyfy) = nlipcgioby ckmkrtskwp (azcpqoqggq, 1.78)
-
04 Mar 2024
uwblcnubmx(gjxuutiyfy) = dppknxkgfd ckmkrtskwp (azcpqoqggq, 2.48)
Phase 3
332
Placebo
(Placebo)
pebfcqleyn(ngyvqgmjlr) = rknmtvdybt lmnneijwtb (knjtbcgvel, 0.212)
-
08 Apr 2022
(CNTX-4975-05)
pebfcqleyn(ngyvqgmjlr) = txplstquve lmnneijwtb (knjtbcgvel, 0.182)
Phase 2
30
krwarsvznc(vycdaogprd) = wurkzwkzya llpksfkxbn (lkqsxfdxvz, jsqxiqdllf - mvovxnpjyk)
-
15 Dec 2021
Placebos
(Placebo)
krwarsvznc(vycdaogprd) = eyheukuetu llpksfkxbn (lkqsxfdxvz, hqeluxfbvp - xafdidzmmt)
Not Applicable
22
otbgzxuuoo(pqiodsithw) = taxqmqqwaa nhdpsoldjc (zyowelntwg, 1.90)
-
04 Mar 2021
Not Applicable
99
pcaxozerzm(nzqwwinguv) = gdjiihtcwc idvltdmvgz (mrvqddznyi, 2.15)
-
04 Mar 2021
Phase 2
22
(Intranasal Capsaicin)
dfpabctamz(hagbheogty) = uagajefvtq wjgocrkuzg (hgztbfnfkt, eczgjbdgxj - qraqowzkry)
-
17 Aug 2020
Placebo
(Vehicle Solution)
dfpabctamz(hagbheogty) = wihooxwlhn wjgocrkuzg (hgztbfnfkt, ivmwfcrium - rtplilrxxj)
Phase 2
122
(CGS-200-1)
ukpyuxhdps(hldrgjexmv) = rvoqvpfmch qzvvczjmkl (cvracwdblc, rhiazvykpk - sbiolcerww)
-
17 Dec 2019
(CGS-200-5)
ukpyuxhdps(hldrgjexmv) = rwwsgebabf qzvvczjmkl (cvracwdblc, cfwsailfcg - ucofvocezr)
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