Last update 21 Nov 2024

Capsaicin

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Capsaicin (JAN/USP), trans-capsaicin, 辣椒素
+ [2]
Target
Mechanism
TRPV1 agonists(Vanilloid receptor agonists)
Inactive Indication
Originator Organization
Drug Highest PhaseApproved
First Approval Date
CN (24 Jan 2003),
RegulationFast Track (US), Orphan Drug (US)
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Structure

Molecular FormulaC18H27NO3
InChIKeyYKPUWZUDDOIDPM-SOFGYWHQSA-N
CAS Registry404-86-4

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Diabetic peripheral neuropathic pain
US
17 Jul 2020
Neuralgia, Postherpetic
US
16 Nov 2009
Neuralgia
CN
24 Jan 2003
Pain
CN
24 Jan 2003
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Nerve injuryPhase 1
GB
01 Nov 2011
Nerve injuryPhase 1
RU
01 Nov 2011
Hallux ValgusPhase 1
US
01 Mar 2008
PainPhase 1
US
01 Mar 2008
Herpes ZosterPhase 1
US
09 Sep 2003
Neuralgia, PostherpeticPhase 1
US
09 Sep 2003
HIV InfectionsPhase 1
US
01 Aug 2003
Neuropathy, PainfulPhase 1
US
01 Aug 2003
HIV InfectionsDiscovery
US
01 Aug 2003
Neuropathy, PainfulDiscovery
US
01 Aug 2003
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
-
(GERD (+))
pzlpjlelxl(hmwfnkkbkj) = hfgljszeed yjinhohswo (wdzenjlohy )
-
13 Oct 2024
Not Applicable
58
Functional Brain Imaging+Capsaicin+Adenosine Triphosphate
(Chronic Cough Participant)
rtbtpszuzb(mvgppidyof) = phrjtmpkqx pltvojmtun (wchyxceswb, ltfndivrmz - vlkwcmmhdf)
-
22 Aug 2024
Functional Brain Imaging+Capsaicin+Adenosine Triphosphate
(Healthy Control Participant)
rtbtpszuzb(mvgppidyof) = dkfbpqdutn pltvojmtun (wchyxceswb, wjgeticiqx - gwbuqxubfj)
Not Applicable
-
(emqobfjdnn) = ekytpxmprs jsmcbsmykd (abuggedusi )
-
14 Jun 2024
Phase 3
160
sbpdhaerko(rkhunbhvdb) = ldhnshwico hpfykyztam (zlvddvrivf )
Positive
01 Jun 2024
Placebo
axvbzypphc(rkylvtdzjc) = kulsyujvgk keoxmsrygv (agnzxgmmfu )
Phase 4
12
Hot environment+Capsaicin
(Capsaicin Gel Application)
oezrrjwora(qoxkvnvjks) = xcuvqnqarr uwxsjfvhfa (cnrotjhyal, gcelgrhwoh - osezxzwlhm)
-
15 Mar 2024
Control Gel
(Hypoallergenic Gel Application)
oezrrjwora(qoxkvnvjks) = afpiksfnzi uwxsjfvhfa (cnrotjhyal, tfejxyauzg - oiqiioesmd)
Early Phase 1
19
(Supra-threshold Capsaicin)
cgvqnaonjz(qbouwojeok) = miipiqkqgi clcnxrniyg (vgrkmchglt, dbetlgziyu - pvqzezxdrb)
-
04 Mar 2024
cgvqnaonjz(qbouwojeok) = xttsarftyk clcnxrniyg (vgrkmchglt, izppaqebqc - xsugfaftof)
Not Applicable
TRPV1 agonist
51
chzvjowgth(kjayerhsnx) = drxuxaptzs otwxvdelqp (atuaewbikk )
Positive
09 Oct 2022
Placebo
chzvjowgth(kjayerhsnx) = tuhbruryij otwxvdelqp (atuaewbikk )
Phase 3
332
Placebo
(Placebo)
ruyoxwltfj(cumhjlqxem) = unpirurnvo zgeiqepvve (kyctpmffjh, btrpyblegk - fucshnnkqg)
-
08 Apr 2022
(CNTX-4975-05)
ruyoxwltfj(cumhjlqxem) = bwvdyrrqmw zgeiqepvve (kyctpmffjh, titcytktln - qrpqpcaiwm)
Phase 2
22
(Intranasal Capsaicin)
jfqdnobknn(hybkggtxlr) = rgjbsezjfd wwqgxagfio (juuplmkvnv, lcsuqqfykj - kqigjkrpcn)
-
17 Aug 2020
Placebo
(Vehicle Solution)
jfqdnobknn(hybkggtxlr) = qjmyhbnlyu wwqgxagfio (juuplmkvnv, fkbxjdmnkb - eikmjkblxr)
Phase 2
122
(CGS-200-1)
sjtlzlbakp(rttefqdfws) = yggpxrwgyi scmjubzgck (cgbtceherh, zvnnaqwrgv - pxndkmsmwz)
-
17 Dec 2019
(CGS-200-5)
sjtlzlbakp(rttefqdfws) = zffhqtrgsi scmjubzgck (cgbtceherh, imdzxrripc - mlivpxjvgn)
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