Last update 11 Jul 2024

Ningetinib Tosylate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Ct-053 free base, Ct-053-ptsa free base, Ct053ptsa free base
+ [4]
Mechanism
AXL inhibitors(AXL receptor tyrosine kinase inhibitors), FLT3 inhibitors(Tyrosine-protein kinase receptor FLT3 inhibitors), MerTK inhibitors(Tyrosine-protein kinase Mer inhibitors)
+ [2]
Drug Highest PhasePhase 2
First Approval Date-
Regulation-

Structure

Molecular FormulaC38H37FN4O8S
InChIKeyNAUYISNCVNUUDK-UHFFFAOYSA-N
CAS Registry1394820-77-9
View All Structures (2)

External Link

KEGGWikiATCDrug Bank
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Metastatic Renal Cell CarcinomaPhase 2
CN
25 Jun 2018
Renal Cell CarcinomaPhase 2
CN
25 Jun 2018
FLT3 positive Acute Myeloid LeukemiaPhase 2
CN
13 Nov 2017
Relapsing acute myeloid leukemiaPhase 2
CN
13 Nov 2017
Non-Small Cell Lung CancerPhase 2
CN
01 Nov 2016
Hepatocellular CarcinomaPhase 2
CN
-
Kidney NeoplasmsPhase 1
CN
30 Jan 2022
LeukemiaPhase 1
CN
30 Jan 2022
Acute Myeloid LeukemiaPhase 1--
Advanced Malignant Solid NeoplasmDiscovery
CN
08 Feb 2014
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1
20
(rqaorwabcs) = No grade 3 or higher CRS or neurotoxicity was observed. Twelve of 14 subjects (86%) experienced grade 1 or 2 CRS, including 2 subjects who experienced grade 2 CRS and 1 subject who had grade 2 neurotoxicity. rzvoktixzd (jbmgvorzvh )
Positive
05 Nov 2020
Phase 1
86
(gqekqveeyp) = ebqbdbdpzj ksjjgffvpc (pkyxsnskyz )
Positive
29 May 2020
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Clinical Trial

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Approval

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Regulation

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