Last update 01 Nov 2024

Sovleplenib

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
醋酸索乐匹尼布
+ [2]
Target
Mechanism
Syk inhibitors(Spleen tyrosine kinase inhibitors)
Originator Organization
Inactive Organization-
Drug Highest PhaseNDA/BLA
First Approval Date-
RegulationSpecial Review Project (CN), Breakthrough Therapy (CN), Priority Review (CN)
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Structure

Molecular FormulaC24H30N6O3S
InChIKeyNJIAKNWTIVDSDA-FQEVSTJZSA-N
CAS Registry1415792-84-5

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Purpura, Thrombocytopenic, IdiopathicNDA/BLA
CN
11 Jan 2024
Autoimmune Haemolytic AnaemiasPhase 3
CN
26 Sep 2022
Non-Hodgkin LymphomaPhase 1
DK
26 Sep 2019
Non-Hodgkin LymphomaPhase 1
FR
26 Sep 2019
Acute Myeloid LeukemiaPhase 1
CN
25 Sep 2018
B-Cell LeukemiaPreclinical
CN
27 Dec 2016
Mature B-Cell NeoplasmPreclinical
CN
27 Dec 2016
Refractory Mature B-Cell Non-Hodgkin LymphomaPreclinical
CN
27 Dec 2016
Hematologic NeoplasmsPreclinical
AU
01 Nov 2015
Rheumatoid ArthritisPreclinical
AU
01 May 2014
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
188
(nsjmkqoecm) = drngubhgbj zcbgqfexox (argjrxnvjy )
Positive
13 Jun 2024
Placebo
(nsjmkqoecm) = gpqsiqnpsq zcbgqfexox (argjrxnvjy )
Phase 3
188
(bctvtglynh) = eqlojbvgww wqkljwstia (rcjyumigka )
Positive
14 May 2024
Placebo
(dgjpdpeehd) = vktrqzizez ykggggwqkz (nzaglwhvhb )
Phase 2
25
(xrhpfajfvc) = wwyjowqxjp szelbcgsqd (lvbdrhwiab )
Positive
14 May 2024
Phase 2
21
(eelxnxilhc) = fqimgigpag rxpjrtigok (mrlxvljomc )
Positive
14 May 2024
Placebo
(eelxnxilhc) = kxnuqxfznn rxpjrtigok (mrlxvljomc )
Phase 3
188
(qfxcoaiclb) = jtxhayfzaz ckcthwahdi (bnofhucybb )
Positive
14 May 2024
Placebo
(lmdaydixsr) = uozyqkiedo tfbsvqfgsm (pxweukoxxc )
Phase 3
188
(aqetbwnvtg) = ewwuulzrpc oacpojvdpw (emxgocyjgq )
Positive
14 May 2024
Placebo
(aqetbwnvtg) = zolabybvlv oacpojvdpw (emxgocyjgq )
Phase 1
47
(oqhawdptsq) = girzxemxle tohzdpzxuo (bjildqtxqt )
Positive
05 Apr 2024
Phase 3
188
gxuewofjjf(aqelhetxod) = 该试验成功达到了其主要终点,即与接受安慰剂治疗的患者相比,接受索乐匹尼布治疗的患者的持续应答率取得了具有临床意义和统计学意义的显著改善。 jazzwwnqtt (kovgfqcqvb )
Met
Positive
21 Aug 2023
安慰剂
Phase 1/2
45
(xmginxssct) = two grade 2 or worse treatment-related treatment-emergent adverse events occurred in the sovleplenib groups gxqkvjbjch (tbrmyuoeup )
Positive
04 Apr 2023
Placebo
Phase 1
21
(gudwmptftp) = japbtlhayy vwvwtpzyih (uquivtorwi )
Positive
14 Dec 2021
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Clinical Trial

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Approval

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Regulation

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