Last update 02 Dec 2024

Estradiol/Trimegestone

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Trimegestone/estradiol, 曲美孕酮/雌二醇, PSK-3987
+ [3]
Target
ER x PR
Mechanism
ERs agonists(Estrogen receptors agonists), PR agonists(Progesterone receptor agonists)
Therapeutic Areas
Endocrinology and Metabolic DiseaseSkin and Musculoskeletal DiseasesOther Diseases
Active Indication
Menopausal syndromeMenopausal symptomsOsteoporosis, Postmenopausal
Inactive Indication-
Originator Organization
SanofiSanofi
Active Organization
Pfizer Inc.Pfizer Inc.Pfizer AB
Inactive Organization-
Drug Highest PhaseApproved
First Approval Date
SE (01 Jan 2000),
Menopausal symptomsOsteoporosis, Postmenopausal
Regulation-
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Structure

Molecular FormulaC22H30O3
InChIKeyJUNDJWOLDSCTFK-MTZCLOFQSA-N
CAS Registry74513-62-5
View All Structures (2)

Related

2
Clinical Trials associated with Estradiol/Trimegestone
NCT00472004 / CompletedPhase 4
A Prospective, Randomized, Open Label Study To Compare The Efficacy, Safety And Tolerability Of 17-B Estradiol/Trimegestone CC 1 Mg (Totelle) And Tibolone (Livial) In Postmenopausal Women.
NCT00195520 / CompletedPhase 4
An Open Assessment of the Effect of Low-Dose Totelle® 1 mg on Menopausal Symptoms, Sexual Function and Quality of Life
100 Clinical Results associated with Estradiol/Trimegestone
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100 Translational Medicine associated with Estradiol/Trimegestone
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100 Patents (Medical) associated with Estradiol/Trimegestone
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1
Literatures (Medical) associated with Estradiol/Trimegestone
01 Jun 2002Revue medicale de Liege
[Pharma-Clinics. Medication of the month. Totelle Cycle: new sequential estrogen/progesterone regimen for hormone replacement therapy in menopause].
100 Deals associated with Estradiol/Trimegestone
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External Link

KEGGWikiATCDrug Bank
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G03FB
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R&D Status

10 top approved records.
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IndicationCountry/LocationOrganizationDate
Menopausal syndrome
ZA
Pfizer Inc.Pfizer Inc.
17 Mar 2009
Menopausal symptoms
SE
-01 Jan 2000
Osteoporosis, Postmenopausal
SE
-01 Jan 2000
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Clinical Result

Indication
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Approval

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Regulation

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