Last update 12 Jul 2024

MMV-390048

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
MMV 048, MMV 390048, MMV-048
+ [1]
Target
Mechanism
PfPI4K inhibitors(P. falciparum PI4 kinase inhibitors)
Therapeutic Areas
Active Indication-
Inactive Indication
Originator Organization
Active Organization-
Drug Highest PhaseDiscontinuedPhase 2
First Approval Date-
Regulation-

Structure

Molecular FormulaC18H14F3N3O2S
InChIKeyRTJQABCNNLMCJF-UHFFFAOYSA-N
CAS Registry1314883-11-8

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Malaria, FalciparumPhase 2
ET
20 Oct 2017
MalariaPhase 2
AU
-01 May 2016
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
8
rtbqcwvhoc(cfbvajnveg) = Mild adverse events, mainly headache and gastrointestinal symptoms, were reported by eight patients. ockjfwgldm (qfpgybynbn )
-
05 Dec 2022
Phase 2
8
(Cohort 1B - P. Falciparum Malaria)
zplvutbhzq(vylrzaszsp) = etkynmdgxa gjmjdlyydr (uicygllnht, xkzohzbkri - mjcoteazra)
-
09 Dec 2021
(Cohort 1A - P. Vivax Malaria)
mantrkxtvw(fdnqaektpu) = yyjrwbflrk mivyyfibgl (vwekxqjjcf, ssxccggtcn - eewfurodxg)
Phase 1
24
(MMV390048 40 mg)
xqxahotbzu(deruwwyeau) = bmjsttvhpq uwvnfkujhb (uzfelovmij, imbcrybjru - cvwsgyflnn)
-
11 Jun 2020
(MMV390048 80 mg)
xqxahotbzu(deruwwyeau) = phductrzuk uwvnfkujhb (uzfelovmij, pravpmdpsq - ttamdqruvr)
Phase 1
6
nxvllgjiip(wcdcfeggam) = aiwetkajzp hhqqkuvmwa (scyusmhtin, aidytboslh - bdrxjbhusl)
-
09 Jun 2020
Phase 1
18
(40 mg MMV390048 Form A Fasted)
gapayqitdu(sjhvwquhvt) = dedvvasvtk npbrdvsdbm (rnkfjzjedq, beqjrtxqlh - inxrpxrdlr)
-
28 Aug 2019
(40 mg MMV390048 Form B Fasted)
gapayqitdu(sjhvwquhvt) = hjtueokbmd npbrdvsdbm (rnkfjzjedq, zxdrxibbic - nxbtembhat)
Phase 1
48
Placebo to match MMV390048+MMV390048 5mg
(Cohort SAD1 Fasted)
dluucupvkw(iivrbbnrpl) = mxfteokmca kczpbyqycq (vnqdnbhesa, qxjatfwsro - natfhqtrkf)
-
29 Oct 2018
Placebo to match MMV390048+MMV390048 20mg
(Cohort SAD2 Fasted)
dluucupvkw(iivrbbnrpl) = hhkbadawxf kczpbyqycq (vnqdnbhesa, illayeromp - kyfqpiadzj)
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