Delving into the Latest Updates on Sulforadex with Synapse

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

(-)-sulforaphane, (R)-sulforaphane, 4-methylsulfinylbutyl isothiocyanate

+ [9]

Target

HDACs x TFEB

Action

inhibitors, activators

Mechanism

HDAC inhibitors(Histone deacetylase inhibitors), TFEB activators(transcription factor EB activators), Epigenetic drug

Therapeutic Areas

NeoplasmsNervous System DiseasesOther Diseases+ [4]

Active Indication

GlioblastomaNeurodevelopmental DisordersPeriodontitis+ [4]

Inactive Indication

Acute Myeloid LeukemiaAutistic DisorderER-positive/HER2-negative Breast Cancer+ [10]

Originator Organization-

Active Organization

Wuhan University

Zhejiang University of Technology

TheraCryf Plc

+ [2]

Inactive Organization-

License Organization

STALICLA SA

TheraCryf Plc

Imperial College London

Drug Highest PhasePhase 1

First Approval Date-

RegulationOrphan Drug (United States)

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Structure/Sequence

Molecular FormulaC6H11NOS2

InChIKeySUVMJBTUFCVSAD-UHFFFAOYSA-N

CAS Registry4478-93-7

ADHD is a neurodevelopmental disorder. It is the most common neurodevelopmental disorder in children and adolescents. Its prevalence is estimated at 5.9% in this population. The symptoms of ADHD combine attention deficit with behavioural disorders such as hyperactivity and impulsivity. Current treatment for ADHD is based on psychotherapeutic and psychoeducational measures aimed at improving behaviour and its impact on the family, social and school environment. Drug treatments may also be used, depending on the impact of the disorder and the effectiveness of alternative treatments. Psychostimulants such as amphetamine derivatives and methylphenidate are around 80% effective.
Sulforaphane is an active substance derived from broccoli that has already been tested in the treatment of other neurodevelopmental disorders. The main hypothesis is that sulforaphane is effective in treating the symptoms of Attention Deficit Disorder with or without Hyperactivity (ADHD) in children.

Start Date01 Dec 2024

Sponsor / Collaborator

Assistance Publique des Hôpitaux de Paris SA

ACTRN12624000812594

/ RecruitingNot ApplicableIIT

Assessing the effects of a broccoli sprout extract on endothelial function in healthy non-pregnant and pregnant women, and pregnant women with a hypertensive disorder of pregnancy

Start Date01 Nov 2024

Sponsor / Collaborator

Monash Health

100 Clinical Results associated with Sulforadex

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100 Translational Medicine associated with Sulforadex

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100 Patents (Medical) associated with Sulforadex

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4,340

Literatures (Medical) associated with Sulforadex

01 Jan 2026·TALANTA

The effect of graphene oxide-polyethylene glycol on lung cell and treatment of sulforaphane

Article

Author: Menevse, Esma ; Kuvvet, Kübra Yilmaz ; Ozcan, Fatih ; Ertul, Seref ; Nedime Korucu, Emine ; Kose, Hamiyet ; Cagil, Esra Maltas

This study explores the cytotoxic and biochemical effects of PEGylated graphene oxide (GO-PEG) nanoparticles, sulforaphane, and Raphanus sativus L. (black radish) juice on BEAS-2B human bronchial epithelial cells. Sulforaphane was extracted from radish juice through pH-adjusted aqueous treatment followed by organic solvent extraction, and quantified via high-performance liquid chromatography (HPLC) at 202 nm, with a retention time of 11.0 min. GO-PEG nanoparticles produced from graphites (50 nm and 400 nm) were tested at concentrations ranging from 50-225 μg mL^-1 and 100-1000 μg mL^-1 to have IC₅₀ values, respectively. Sulforaphane and black radish juice were also administered. The MTT assay revealed IC₅₀ values of 8.7 μg mL^-1 for sulforaphane, 197.0 mg mL^-1 for black radish juice, 175.8 μg mL^-1 for GO-PEG (50 nm), and 650.6 μg mL^-1 for GO-PEG (400 nm). Biochemical analyses showed that sulforaphane and radish juice decreased IL-6 levels and increased antioxidant enzyme activities (GSH-Px and CAT). These results highlight the therapeutic potential of GO-PEG, sulforaphane, and black radish juice for anti-inflammatory and antioxidant applications.

31 Dec 2025·Epigenetics

An overview of potential of natural compounds to regulate epigenetic modifications in colorectal cancer: a recent update

Review

Author: Duttaroy, Asim K. ; Philip, Neha ; Pathak, Surajit ; Siripragada, Sravani ; Roy, Susmita ; Banerjee, Antara ; Deka, Dikshita ; Ayyadurai, Pavithra ; Kondaveeti, Suresh Babu

Colorectal cancer (CRC) remains an alarming global health concern despite advancements in treatment modalities over recent decades. Among the various factors contributing to CRC, this review emphasizes the critical role of epigenetic mechanisms in its pathogenesis and progression. This review also describes the potential role of natural compounds in altering the epigenetic landscape, focused mainly on DNA methylation, histone modification, and non-coding RNAs. Publications from the previous five years were searched and retrieved using well-known search engines and databases like PubMed, Google Scholar, and ScienceDirect. Keywords like CRC/colorectal cancer, CAC/Colitis associated CRC, inflammasomes, epigenetic modulation, genistein, curcumin, quercetin, resveratrol, anthocyanins, sulforaphane, and epigallocatechin-3-gallate were used in various combinations during the search. These natural compounds predominantly affect pathways such as Wnt/β-catenin, NF-κB, and PI3K/AKT to suppress CRC cell proliferation and oxidative stress and enhance anti-inflammation and apoptosis. However, their clinical use is restricted due to their low bioavailability. However, multiple methods exist to overcome challenges like this, including but not limited to structural modifications, nanoparticle encapsulations, bio-enhancers, and novel advanced delivery systems. These methods improve their potential as supportive therapies that target CRC progression epigenetically with fewer side effects. Current research focuses on enhancing epigenetic targeting to control CRC progression while minimizing side effects, emphasizing improved specificity, bioavailability, and efficacy as standalone or synergistic therapies.

31 Dec 2025·Bioengineered

Statement of Retraction: Sulforaphane ameliorates amyloid-β-induced inflammatory injury by suppressing the PARP1/SIRT1 pathway in retinal pigment epithelial cells

Article

17

News (Medical) associated with Sulforadex

29 Jul 2025

·www.businesswire.com

Broc Shot Becomes the First Supplement to Receive the Seal of Recognition From the National Psoriasis Foundation

LOS ANGELES--(BUSINESS WIRE)--Broc Shot is the first supplement to earn the Seal of Recognition from the National Psoriasis Foundation (NPF). This recognition highlights Broc Shot’s support for skin health from within, offering a natural, gentle and non-irritating option for those living with psoriasis-prone skin. A Breakthrough for Psoriasis: Broc Shot Earns First-Ever NPF Supplement Seal. What is Psoriasis-prone skin? Currently, over 8 million Americans—about 2-3% of the global population—live with psoriasis. This lifelong inflammatory disease is not a simple skin rash. It impacts the skin, joints, and other organs, and is often misunderstood as merely a cosmetic issue. Nearly 60% of those with psoriasis-prone skin report it significantly affects their daily lives. Psoriasis is also linked to other health issues, including heart disease, metabolic syndrome, depression, and psoriatic arthritis. While severity varies, many people experience a notable impact on their quality of life. Conventional treatments like corticosteroids or UV therapy are common but can cause side effects such as dryness, irritation, or long-term skin sensitivity. Additionally, these treatments may lose effectiveness over time and can contribute to other health concerns. Introducing Broc Shot: Natural Supplement Powered by Sulforaphane to Calm Skin from Within Broc Shot is a unique supplement formulated with natural sulforaphane, a compound derived from whole broccoli seed powder. Sulforaphane has been clinically studied for its ability to support cellular health1 and help the body respond to oxidative stress2 and inflammation3—key drivers of skin issues like psoriasis. In 3 distinct studies, sulforaphane was clinically demonstrated to improve psoriasis-prone skin. What is Sulforaphane and How Sulforaphane Can Help Psoriasis-Prone Skin Sulforaphane is a sulfur-rich phytochemical found in cruciferous vegetables with the highest levels derived from broccoli seeds. Sulforaphane has over 1000 peer reviewed studies and articles demonstrating its ability to repair and nurture our gut, detoxify the body and reduce and prevent inflammation. Sulforaphane benefits include: - Supports Cellular Health: Sulforaphane is clinically studied to help the body respond to oxidative stress and inflammation — two root causes of psoriasis flare-ups. - Supports Immune Balance for psoriasis-prone skin: May help slow the rapid skin cell turnover process seen in psoriasis. - Supports Detoxification and Gut Health: Natural sulforaphane enhances the body’s ability to neutralize environmental toxins and supports gut barrier integrity, which can influence skin health. "NPF is pleased to recognize Broc Shot and its potential to support the overall health of people with psoriasis," said the National Psoriasis Foundation. "This is the first supplement to earn the NPF Seal, and Broc Shot in conjunction with proper treatment can help our community live healthier lives." Broc Shot is a simple daily ritual—just one sachet mixed with water— delivering 12 mg of natural sulforaphane. As one of the most effective supplements for psoriasis-prone skin, Broc Shot offers a non-irritating, long-term solution backed by science. Whether you’re newly exploring sulforaphane benefits or looking for gentle support to help minimize skin flare-ups, Broc Shot is a trusted option to support healthier skin from within. Broc Shot is Non-GMO certified, Vegan, pesticide-free, gluten-free, plastic-free and never stabilized. “We are honored that the National Psoriasis Foundation has awarded Broc Shot its Seal of Recognition. Our mission is to deliver a potent, natural source of sulforaphane to support rapid and lasting improvements in skin health. This recognition affirms our commitment to providing those with psoriasis-prone skin a safe and effective solution—and it inspires us to keep innovating science-backed formulas that truly make a difference in people’s lives,” said Benjamin Silver, co-founder of Broc Shot. About Broc Shot: Broc Shot is dedicated to providing natural, science-backed supplements that support overall health and wellness. Founded on the principles of transparency and quality, Broc Shot features natural sulforaphane derived from whole broccoli seed powder, formulated to help promote detoxification and gut health, and reduce inflammation. Committed to innovation and safety, Broc Shot is Non-GMO certified, vegan, pesticide-free, gluten-free, and plastic-free in compostable packaging. For additional information about Broc Shot, visit www.brocshot.com About the National Psoriasis Foundation: NPF is the leading research, advocacy, and support organization representing more than 8 million people in the U.S. and over 125 million people worldwide who live with psoriasis or psoriatic arthritis. The mission of NPF is to drive efforts to cure psoriatic disease and improve the lives of all those affected. NPF is committed to creating a world free from the burdens of psoriatic disease and immediately optimizing the health of our constituents. 1 https://pubmed.ncbi.nlm.nih.gov/35126161/ 2 https://pubmed.ncbi.nlm.nih.gov/38007430/ 3 https://pubmed.ncbi.nlm.nih.gov/22453842/

07 Apr 2025

·www.prnewswire.com

Clinical Study Shows Modulation of Ki-67 Markers by those taking Avmacol® in Former Smokers at High-risk for Lung Cancer

LANCASTER, S.C., April 7, 2025 /PRNewswire/ -- Nutramax Laboratories Consumer Care, Inc. is pleased to share the results of a newly published human clinical study by Yuan et al., in the Cancer Prevention Research journal. The study indicates that Avmacol®, an oral sulforaphane-producing supplement with glucoraphanin and active myrosinase enzyme, is safe and effective at reducing the number of cells with positive Ki-67 in bronchial biopsies in former smokers that are at high-risk for lung cancer. These results significantly add to the growing body of knowledge using Avmacol® as the study product, contributing to the #1 researched sulforaphane-producing brand^. Sulforaphane is an isothiocyanate widely studied for its' detoxification, cellular health, and antioxidant benefits. Sulforaphane is naturally created in the body with glucoraphanin and an active myrosinase enzyme. In this double-blind, placebo-controlled, randomized clinical study, 43 former smokers were assigned to either the sulforaphane (Avmacol®) or placebo group. Subjects in the sulforaphane group took 120 milligrams of glucoraphanin per day for 12 months. One of the primary targets included the Ki-67 index, which is a cancer proliferation marker. Results indicated a 20% decrease of Ki-67 in the sulforaphane group as compared to a 65% increase in the placebo group. "The promising results from this phase II clinical trial provides support for a phase III intervention trial with a large sample size and long-term period to directly examine the efficacy of lung cancer prevention by sulforaphane," said Dr. Jian-Min Yuan, principial investigator on this study from the University of Pittsburgh Medical Center Hillman Cancer Center. The ingredients to make sulforaphane in the body are found in Avmacol® and Avmacol® Extra Strength. The Avmacol® brand is the #1 researched sulforaphane-producing brand^. "This study adds to the rich body of scientific evidence in understanding the nutritional benefits of sulforaphane for targeted care in complex cases," said Meghan Hamrock, MS, MPH, Director of Consumer Marketing and Clinical Nutrition for Nutramax Laboratories Consumer Care, Inc. ABOUT NUTRAMAX LABORATORIES CONSUMER CARE, INC Nutramax Laboratories Consumer Care, Inc. is focused on researching and developing products to promote consumer health. Since its inception in 1992, the Christian-based company has been committed to developing high-quality products. Cosamin® is the #1 researched glucosamine/chondroitin sulfate brand and Avmacol® is the #1 researched sulforaphane-producing brand based on U.S. studies published in peer-reviewed journals. Our products are backed by science and manufactured in world-class facilities at our headquarters in Lancaster, South Carolina where we employ over 800 people nationwide. For more information, visit Avmacol.com or call Customer Service at 888-886-6442. ^ The Avmacol® brand has been selected for use in more sulforaphane human clinical trials than any other sulforaphane-producing supplement. SOURCE Nutramax Laboratories, Inc. WANT YOUR COMPANY'S NEWS FEATURED ON PRNEWSWIRE.COM? 440k+ Newsrooms & Influencers 9k+ Digital Media Outlets 270k+ Journalists Opted In GET STARTED

Clinical ResultPhase 2Phase 3

04 Mar 2024

·www.biospace.com

Therapeutic Solutions International Granted Patent on Commercially Available QuadraMune® Nutraceutical for Increasing Natural Killer Cell Immunity in COVID-19 Patients

Latest Patent to Complement Issued Claims on Viral Inhibition, Adaptive Immune Stimulation, and Brain Protection/Regeneration ELK CITY, Idaho--(BUSINESS WIRE)-- Therapeutic Solutions International, Inc. (TSOI), a clinical-stage stem cell and immunotherapy company, announced today the granting of a patent covering the ability of QuadraMune® and similar compositions, to stimulate natural killer (NK) cell activity in patients with COVID-19. NK cells are the first line of defense against viruses and cancers1. The Company was previously awarded by the United States Patent and Trademark Office the following QuadraMune® related patents: Patent #11,229,674, covering inhibition of the immune suppressing enzyme indolamine 2,3 dioxygenase2. It is published that this enzyme plays a fundamental role in immune suppression by cancer3, as well as numerous viruses including SARS-CoV-2, the causative agent of COVID-194. Patent #11,266,707, “Nutraceuticals for the prevention, inhibition, and treatment of SARS-CoV-2 and associated COVID-19”5. Patent #11,504,410, covering use of QuadraMune® and its derivatives for protecting and restoring brain function after neurological damage, including Long COVID6. Patent #11759495, covering upregulation of T regulatory cells for suppression of suicidal ideation7. “In addition to this important validation from the USPTO, the fact that the ingredients in QuadraMune® have been reported by institutions such as Johns Hopkins University to suppress SARS-CoV-2 is strongly encouraging,” said Famela Ramos, Vice President of Business Development for the Company. “Our Company is driven by a desire to address unmet medical needs, whether it is through developing state of the art stem cell and gene therapies, or science-backed nutraceuticals,” said Timothy Dixon, President, and CEO of the Company. “The importance of NK cells in protecting the body against cancer and viruses is well known, the fact that this can be performed using a low-cost nutraceutical approach has implications in both oncology and virology.” About Therapeutic Solutions International, Inc. Therapeutic Solutions International is focused on immune modulation for the treatment of several specific diseases. The Company's corporate website is . 1 Cerwenka and Lanier. Natural killer cells, viruses and cancer. Nat Rev Immunol. 2001 Oct;1(1):41-9. 2 3 Ricuitti et al. Targeting indoleamine-2,3-dioxygenase in cancer: Scientific rationale and clinical evidence. Pharmacol Ther. 2019 Apr:196:105-116. 4 Guo et al. Indoleamine 2,3-dioxygenase (IDO)-1 and IDO-2 activity and severe course of COVID-19. J Pathol. 2022 Mar;256(3):256-261. 5 6 7 8 Johns Hopkins University Publishes Efficacy of QuadraMune™ Ingredient Sulforaphane at Inhibiting Coronavirus in Laboratory Studies | BioSpace

Immunotherapy

100 Deals associated with Sulforadex

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External Link

KEGG	Wiki	ATC	Drug Bank
-	-	-	DB12422

R&D Status

10 top R&D records.

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Indication	Highest Phase	Country/Location	Organization	Date
Respiratory Distress Syndrome, Adult	Phase 3	United Kingdom	TheraCryf Plc	23 Nov 2020
SARS-CoV-2 acute respiratory disease	Phase 3	United Kingdom	TheraCryf Plc	19 Sep 2020
ER-positive/HER2-negative Breast Cancer	Phase 2	Belgium	-	01 Oct 2016
ER-positive/HER2-negative Breast Cancer	Phase 2	France	-	01 Oct 2016
ER-positive/HER2-negative Breast Cancer	Phase 2	Spain	-	01 Oct 2016
ER-positive/HER2-negative Breast Cancer	Phase 2	United Kingdom	-	01 Oct 2016
Metastatic breast cancer	Phase 2	Belgium	-	01 Oct 2016
Metastatic breast cancer	Phase 2	France	-	01 Oct 2016
Metastatic breast cancer	Phase 2	Spain	-	01 Oct 2016
Metastatic breast cancer	Phase 2	United Kingdom	-	01 Oct 2016

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Clinical Result

Indication

Phase

Evaluation

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


NCT03232138 (CTgov)	Phase 2	Lung Cancer	43	Sulforaphane (Sulforaphane (Study Drug))	jgsexqjyew(svcgkmzlvp) = fakxckglvp qtskuqhfxv (uuxhutajjl, 0.38) View more	-	17 Dec 2024
				Placebo (Placebo)	jgsexqjyew(svcgkmzlvp) = tgazwhqhll qtskuqhfxv (uuxhutajjl, 0.41) View more
NCT05153174 (CTgov)	Phase 1	Chronic Kidney Diseases	18	Sulforaphane (2 Tablets of Sulforaphane)	wiodoktvik(kodgbaqshd) = gkmrmkwjze oopecswwok (attavxgvvm, 376.5) View more	-	12 Aug 2024
				Sulforaphane (4 Tablets of Sulforaphane)	wiodoktvik(kodgbaqshd) = huopzutsym oopecswwok (attavxgvvm, 335.8) View more
NCT02614742 (SAS Study, Pubmed)	Phase 2	Subarachnoid Hemorrhage	105	SFX-01 300 mg BD	lreqqpiche(liroycywuh) = 9 SFX-01 (16.7%), 1 placebo (2.0%) dkbmrrajgd (etvjocfkaf )	Negative	19 Jul 2024
ERS2022	Not Applicable	COVID-19	133	S-SFN 300mg	xwrlmneqvm(elylbvtine) = fojqfarqnd bdxwdmwotx (afrylwxdtr )	Negative	04 Sep 2022
				Placebo	xwrlmneqvm(elylbvtine) = eictfcfura bdxwdmwotx (afrylwxdtr )
NCT02810964 (CTgov)	Phase 2	Schizoaffective disorder \| Schizophrenia	64	Sulforaphane (Sulforaphane Nutraceutical)	eplbvvuvrw(mxtndktqvf) = xmwdiclygl ibrkivnnul (fwniohdsep, 12.2) View more	-	27 Jul 2021
				Identical-appearing Placebo (Identical-appearing Placebo)	eplbvvuvrw(mxtndktqvf) = tdqzlslter ibrkivnnul (fwniohdsep, 13.0) View more
NCT02561481 (Pubmed \| Mol Autism) Manual	Phase 1/2	Autism Spectrum Disorder	57	sulforaphane	moqifnyecf(hqwszuypdl) = houkcyzenk xpmlclkwfn (ibpbtynjhl, -0.46 to 0.88) View more	Negative	25 May 2021
				Placebo	moqifnyecf(hqwszuypdl) = ykleosuplh xpmlclkwfn (ibpbtynjhl, -0.52 to 0.72)
NCT02561481 (CTgov)	Phase 1/2	Autism Spectrum Disorder	60	Sulforaphane (Sulforaphane)	tibwfduzbw(tawbmjhttf) = tksuzkkezd icphtpznsx (eorzezwzzd, 0.67) View more	-	25 Nov 2020
				Placebo (Placebo)	tibwfduzbw(tawbmjhttf) = hwvqhvsrwi icphtpznsx (eorzezwzzd, 0.57) View more
NCT02909959 (CTgov)	Phase 2	Autism Spectrum Disorder \| Autistic Disorder \| Pervasive child development disorders	48	Sulforaphane (Sulforaphane)	dakwwcsknq(qnobvahxfu) = badzmbxpyu ilfamumidw (slzbimhswa, 7.4) View more	-	15 May 2020
				Placebo (Placebo)	dakwwcsknq(qnobvahxfu) = lhvjocjdyd ilfamumidw (slzbimhswa, 4.6) View more
NCT02970682 (STEM, ESMO2019) Manual	Phase 2	Metastatic human epidermal growth factor 2 positive carcinoma of breast ER Positive \| HER2 Negative	46	Aromatase Inhibitors+SFX-01	nkxahrrmms(okjksmmnfv) = SFX-01 was well tolerated with grade 1/2 nausea (54.3%) and dyspepsia (32.6%) the most frequent adverse events (AEs). hwwvwfgqva (upmnigqgia )	Positive	29 Sep 2019
				Tamoxifen+SFX-01
AAN2018	Phase 2	Autism Spectrum Disorder	50	Sulforaphane	hzpnarcvwd(puqtkwisaw) = 13% mmzkubuppq (cvanlpstue ) View more	Positive	10 Apr 2018