Drug Type Small molecule drug |
Synonyms AZD 4877, AZD4877 |
Target |
Action inhibitors |
Mechanism KIF11 inhibitors(Kinesin-like protein 1 inhibitors) |
Therapeutic Areas |
Active Indication- |
Inactive Indication |
Originator Organization |
Active Organization- |
Inactive Organization |
Drug Highest PhaseDiscontinuedPhase 2 |
First Approval Date- |
Regulation- |
Molecular FormulaC28H33N5O2S |
InChIKeySMFXSYMLJDHGIE-UHFFFAOYSA-N |
CAS Registry758722-49-5 |
KEGG | Wiki | ATC | Drug Bank |
---|---|---|---|
- | - | - |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Bladder Cancer | Phase 2 | United States | 01 May 2008 | |
Bladder Cancer | Phase 2 | Canada | 01 May 2008 | |
Bladder Cancer | Phase 2 | Germany | 01 May 2008 | |
Bladder Cancer | Phase 2 | Spain | 01 May 2008 | |
Bladder Cancer | Phase 2 | United Kingdom | 01 May 2008 | |
Renal Pelvis Carcinoma | Phase 2 | United States | 01 May 2008 | |
Renal Pelvis Carcinoma | Phase 2 | Canada | 01 May 2008 | |
Renal Pelvis Carcinoma | Phase 2 | Germany | 01 May 2008 | |
Renal Pelvis Carcinoma | Phase 2 | Spain | 01 May 2008 | |
Renal Pelvis Carcinoma | Phase 2 | United Kingdom | 01 May 2008 |
Phase 2 | 39 | AZD4877 25 mg | hktqkknqmn(qjqodpvrtm) = 6 patients mqarnrbnkn (rmzkvfqnef ) View more | Negative | 01 Aug 2013 | ||
Phase 1/2 | 47 | uwlysjbywj(jdstwhuoxw) = ifvmchkrcx zqfkwxsebv (mcurpywggn ) | Negative | 01 Jun 2012 | |||
Phase 2 | 54 | szhevynesp = twxssrmnkt pmcuxwfgsx (plenlxemem, jowyrsoofw - xpbgdoarkl) View more | - | 12 Jan 2011 | |||
Phase 1 | Refractory acute myeloid leukemia Consolidation | 24 | kjzdxatvhv(ylcwmktmke) = Mucositis was the DLT at 18 mg/day; with 1 pt developing Gr 3 palmar-plantar syndrome at this dose ldaxqcefxx (elhaakrigl ) View more | - | 20 May 2009 | ||
Phase 1 | - | penllbfusl(adysfjlzoe) = jpcdjlscfq alltiwjmly (wiqsdaozxf ) View more | - | 20 May 2008 |