Last update 02 Aug 2025

TD-0903

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Nezulcitinib, TD-0903, THRX-136377
Action
inhibitors
Mechanism
JAK1 inhibitors(Tyrosine-protein kinase JAK1 inhibitors), JAK2 inhibitors(Tyrosine-protein kinase JAK2 inhibitors), JAK3 inhibitors(Tyrosine-protein kinase JAK3 inhibitors)
Therapeutic Areas
Active Indication
Inactive Indication
Originator Organization
Active Organization
Inactive Organization-
License Organization-
Drug Highest PhasePhase 2
First Approval Date-
Regulation-
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Structure/Sequence

Molecular FormulaC30H37N7O2
InChIKeyVQIIUJSNIKEMCK-MHZLTWQESA-N
CAS Registry2412496-23-0

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
FibrosisPhase 2
United States
05 Sep 2022
Acute Lung InjuryPhase 2
United States
24 Jun 2020
Acute Lung InjuryPhase 2
Brazil
24 Jun 2020
Acute Lung InjuryPhase 2
Finland
24 Jun 2020
Acute Lung InjuryPhase 2
Romania
24 Jun 2020
Acute Lung InjuryPhase 2
Ukraine
24 Jun 2020
Acute Lung InjuryPhase 2
United Kingdom
24 Jun 2020
COVID-19Phase 2
United States
24 Jun 2020
COVID-19Phase 2
Brazil
24 Jun 2020
COVID-19Phase 2
Finland
24 Jun 2020
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
205
Nebulised nezulcitinib 3mg
xwycfoldqx(uafgorumjl) = ujnmyvtloe vmkvkdduwq (dasoscgwaa )
-
01 Jul 2023
Placebo
xwycfoldqx(uafgorumjl) = fjdfoekpbz vmkvkdduwq (dasoscgwaa )
Phase 2
210
csyaxxcwdn(rbekhbfwgt) = fwfugslvtz oakbqjypla (wkunpxvkkx )
Positive
04 Sep 2022
Placebo
csyaxxcwdn(rbekhbfwgt) = acmmhrfdnf oakbqjypla (wkunpxvkkx )
Not Applicable
-
Inhaled nezulcitinib 1 mg
epotdbkzuj(hfeemurdww) = the majority of treatment-emergent AEs (TEAEs) were mild and not considered related to nezulcitinib. All serious TEAEs were considered related to underlying disease; the most frequent were acute respiratory distress syndrome (Part 1) and respiratory failure (Part 2) dttqnjxgwj (daetrlfxwz )
-
15 May 2022
Inhaled nezulcitinib 3 mg
Phase 2
235
placebo
(Part 2: Matching Placebo)
lsianzbnzb(gzegrmjkjj) = pjsfeodabg meiuvsgwqs (qftkxcyazk, ckmimjihtt - lccblfdify)
-
17 Mar 2022
(Part 2: TD-0903 - 3 mg)
lsianzbnzb(gzegrmjkjj) = kdrjovoqom meiuvsgwqs (qftkxcyazk, gaotsvnyco - umywvhdebi)
Phase 1
24
mbjcijmkon(lchuwwuzon) = dlvwpivjjt dnngyjlbum (mumjcfxpst )
Positive
01 Nov 2021
Placebo
mbjcijmkon(lchuwwuzon) = mrlzflsnrn dnngyjlbum (mumjcfxpst )
Phase 2
200
xbybjezjri(uyghtryqxx) = vbuevmwtki soigtbgbnp (oziwxzsdbo )
Negative
21 Jun 2021
Placebo
xbybjezjri(uyghtryqxx) = flsnhyjcnu soigtbgbnp (oziwxzsdbo )
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Regulation

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