Last update 21 Nov 2024

NPT-189

Overview

Basic Info

Drug Type
Fusion protein
Synonyms
Target
Amyloid light chain x TTR
Mechanism
TTR inhibitors(Transthyretin inhibitors), amyloid light chain inhibitors
Therapeutic Areas
NeoplasmsImmune System DiseasesNervous System Diseases+ [4]
Active Indication
Amyloidosis, Hereditary, Transthyretin-RelatedImmunoglobulin Light-Chain Amyloidosis
Inactive Indication-
Originator Organization
Proclara Biosciences, Inc.Proclara Biosciences, Inc.
Active Organization
Proclara Biosciences, Inc.Proclara Biosciences, Inc.
Inactive Organization-
Drug Highest PhasePhase 1
First Approval Date-
Regulation-
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Related

4
Clinical Trials associated with NPT-189
NCT03879278 / TerminatedPhase 1
A Phase 1 Randomized, Double-Blind, Placebo-Controlled, Multiple Ascending Dose Study to Evaluate the Safety, Tolerability and Pharmacokinetics of NPT189 in Healthy Subjects
NL-OMON48151 / CompletedNot Applicable
A phase I randomized, double-blind, placebo-controlled, multiple ascending dose study to evaluate the safety, tolerability and pharmacokinetics of NPT189 in healthy subjects - Study to evaluate the safety, tolerability and PK of NPT189
NCT03610035 / CompletedPhase 1
A Phase 1 Randomized, Double-Blind, Placebo-Controlled, Single Ascending Dose Study to Evaluate the Safety, Tolerability and Pharmacokinetics of NPT189 in Healthy Subjects
100 Clinical Results associated with NPT-189
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100 Translational Medicine associated with NPT-189
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100 Patents (Medical) associated with NPT-189
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100 Deals associated with NPT-189
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
AmyloidosisPhase 2
NL
Proclara Biosciences, Inc.Proclara Biosciences, Inc.
24 Jul 2018
Amyloidosis, Hereditary, Transthyretin-RelatedPhase 1
US
Proclara Biosciences, Inc.Proclara Biosciences, Inc.
30 Jan 2022
Immunoglobulin Light-Chain AmyloidosisPhase 1
US
Proclara Biosciences, Inc.Proclara Biosciences, Inc.
30 Jan 2022
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Clinical Result

Indication
Phase
Evaluation
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Approval

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Regulation

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