Last update 11 Oct 2025

YTS-104

Overview

Basic Info

Drug Type
Autologous CAR-T
Synonyms
合成性T细胞受体抗原受体, YTS 104, YTS104
Target
LILRB4
Action
inhibitors
Mechanism
LILRB4 inhibitors(Leukocyte immunoglobulin-like receptor subfamily B member 4 inhibitors)
Therapeutic Areas
NeoplasmsImmune System DiseasesHemic and Lymphatic Diseases+ [1]
Active Indication
Relapse multiple myelomaChronic Myelogenous LeukemiaChronic Myelomonocytic Leukemia+ [3]
Inactive Indication-
Originator Organization
BriSTAR Immunotech LimitedBriSTAR Immunotech Limited
Active Organization
BriSTAR Immunotech LimitedBriSTAR Immunotech Limited
Inactive Organization-
License Organization-
Drug Highest PhasePhase 1
First Approval Date-
RegulationOrphan Drug (United States)
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Related

3
Clinical Trials associated with YTS-104
NCT05913804
/ RecruitingPhase 1IIT
An Exploratory Clinical Study on the Safety and Efficacy of YTS104 Cell Injection in the Treatment of Relapsed or Refractory Multiple Myeloma
NCT05548088
/ CompletedPhase 1IIT
An Exploratory Clinical Study of the Safety and Efficacy of LILRB4 STAR-T Cells for the Treatment of Relapsed/Refractory Acute Myeloid Leukemia/Chronic Granulocytic-Mononocytic Leukemia
NCT05739409
/ Unknown statusNot ApplicableIIT
An Exploratory Clinical Study on the Safety and Efficacy of LILRB4 STAR-T Cells in the Treatment of Monocytic Leukemia
100 Clinical Results associated with YTS-104
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100 Translational Medicine associated with YTS-104
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100 Patents (Medical) associated with YTS-104
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100 Deals associated with YTS-104
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Relapse multiple myelomaPhase 1
China
BriSTAR Immunotech LimitedBriSTAR Immunotech Limited
28 Jun 2023
Chronic Myelogenous LeukemiaPhase 1
China
-25 May 2023
Chronic Myelomonocytic LeukemiaPhase 1
China
-25 May 2023
Refractory acute myeloid leukemiaPhase 1
China
-25 May 2023
Acute Myeloid LeukemiaPhase 1
China
BriSTAR Immunotech LimitedBriSTAR Immunotech Limited
-
Relapsing acute myeloid leukemiaIND Application
China
BriSTAR Immunotech LimitedBriSTAR Immunotech Limited
03 Nov 2023
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Clinical Result

Indication
Phase
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Clinical Trial

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Approval

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Regulation

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