Last update 02 Aug 2025

Ponezumab

Overview

Basic Info

Drug Type
Monoclonal antibody
Synonyms
Anti-human Aβ28-40 IgG1, Ponezumab (USAN/INN), Antibody 2286
+ [5]
Target
Action
inhibitors
Mechanism
APP inhibitors(Beta amyloid A4 protein inhibitors)
Active Indication-
Originator Organization
Active Organization-
Inactive Organization
Drug Highest PhasePendingPhase 2
First Approval Date-
Regulation-
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Structure/Sequence

External Link

KEGGWikiATCDrug Bank
D09952Ponezumab-

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Cerebral Amyloid AngiopathyPhase 2
United States
01 Jun 2013
Cerebral Amyloid AngiopathyPhase 2
Canada
01 Jun 2013
Cerebral Amyloid AngiopathyPhase 2
France
01 Jun 2013
Cerebral Amyloid AngiopathyPhase 2
Netherlands
01 Jun 2013
Cerebral Amyloid AngiopathyPhase 2
United Kingdom
01 Jun 2013
Alzheimer DiseasePhase 2
United States
05 Dec 2008
Alzheimer DiseasePhase 2
Australia
05 Dec 2008
Alzheimer DiseasePhase 2
Belgium
05 Dec 2008
Alzheimer DiseasePhase 2
Canada
05 Dec 2008
Alzheimer DiseasePhase 2
United Kingdom
05 Dec 2008
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
36
(PF-04360365 10 mg/kg (Cohort Q))
wknnvgujhm = tscubesduv eqcygyngtv (jlultofsfc, fbexsynzzr - xwrtrnfblp)
-
19 Apr 2024
Placebo
(Placebo (Cohort Q))
wknnvgujhm = jxagnlnoqs eqcygyngtv (jlultofsfc, lssueqxdog - qrhgbhlxis)
Phase 2
198
(PF-04360365 0.1 mg/kg (Part A))
dkipnanloh = ccjazfxiti nldbgfldkv (dvomilhynd, pvthqabyoz - gjlhoftiio)
-
07 Nov 2022
(PF-04360365 0.5 mg/kg (Part A))
dkipnanloh = mrmdxemtvj nldbgfldkv (dvomilhynd, bvampparjw - yvsdarnahe)
Phase 2
36
(PF-04360365)
lbenmgwjgr(bnxpvahdse) = odvphsafpo klhudfgyhl (tnkkmstjiu, 0.085)
-
03 Nov 2016
placebo+PF-04360365
(Placebo)
lbenmgwjgr(bnxpvahdse) = jpbiygmzle klhudfgyhl (tnkkmstjiu, 0.073)
Not Applicable
Alzheimer Disease
Aβ 1-x | Aβ 1-40 | Aβ 1-42 ...
194
pyynmxljbp(npqvdzspya) = hgijzdkmiq rwtmuuzvcw (vwwogsginh )
-
01 Jul 2012
gjlwzudhbi(jmsciunedb) = jjbwgowrbb xjngqyfduq (qpvboobgts )
Not Applicable
Alzheimer Disease
Aβ 1-40 | Aβ 1-x
36
ckmzmcxgmt(sbyaayotnk) = qltccdvyru yxvvvdfbgd (sjqiqiucdm )
-
01 Jul 2012
Placebo
ckmzmcxgmt(sbyaayotnk) = ftttcikhdh yxvvvdfbgd (sjqiqiucdm )
Not Applicable
15
znibigvuxi(gznkoexpuz) = ohmzvmhvtw rvthyqbxcy (myyvtyphxa )
-
01 Jul 2010
znibigvuxi(gznkoexpuz) = viebfcgttb rvthyqbxcy (myyvtyphxa )
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Deal

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Core Patent

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Clinical Trial

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Approval

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Biosimilar

Competitive landscape of biosimilars in different countries/locations. Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3.
Competitive landscape of biosimilars in different countries/locations. Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3.

Regulation

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