Delving into the Latest Updates on Aminosalicylic acid with Synapse

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

AMINOSALICYLIC ACID RESIN COMPLEX, Aminosalicylic acid (USP), para-aminosalicylic acid

+ [7]

Target-

Action-

Mechanism-

Therapeutic Areas

Infectious Diseases

Active Indication

Tuberculosis, Multidrug-Resistant

Inactive Indication

Crohn Disease

Originator Organization

Eurocept International B.V.

Active Organization

Eurocept International B.V.

Inactive Organization

Bristol Myers Squibb Co.Jacobus Pharmaceutical Co., Inc.

Drug Highest PhaseApproved

First Approval Date

European Union (07 Apr 2014),

Tuberculosis, Multidrug-Resistant

RegulationOrphan Drug (European Union)

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Structure/Sequence

Molecular FormulaC7H7NO3

InChIKeyWUBBRNOQWQTFEX-UHFFFAOYSA-N

CAS Registry65-49-6

Para-aminosalicylic acid enteric-coated granules (4 g) produced by Chongqing Huabang Pharmaceutical Co., Ltd. was used as the test preparation (T). According to the relevant provisions of bioequivalence tests, a bioequivalence test was conducted with para-aminosalicylic acid enteric-coated granules (4 g, PASER®) produced by Jacobus Pharmaceutical as the reference preparation (R).

Start Date13 Sep 2018

Sponsor / Collaborator

Chongqing Huapont Pharmaceutical Co. Ltd.

CTR20181586

/ CompletedNot Applicable

对氨基水杨酸肠溶颗粒的随机、开放、单次给药、双周期、双交叉空腹预BE试验

[Translation] A randomized, open-label, single-dose, two-period, double-crossover fasting pre-BE trial of p-aminosalicylic acid enteric-coated granules

以重庆华邦制药有限公司生产的对氨基水杨酸肠溶颗粒为受试制剂，按有关生物等效性试验的规定，与JACOBUS PHARMACEUTICAL公司生产的对氨基水杨酸肠溶颗粒（商品名：PASER®）进行人体生物利用度与生物等效性试验，比较受试制剂和参比制剂是否生物等效。

[Translation]

Using p-aminosalicylic acid enteric-coated granules produced by Chongqing Huabang Pharmaceutical Co., Ltd. as the test preparation, human bioavailability and bioequivalence tests were conducted with p-aminosalicylic acid enteric-coated granules (trade name: PASER®) produced by Jacobus Pharmaceutical Co., Ltd. in accordance with the relevant provisions of bioequivalence tests to compare whether the test preparation and the reference preparation are bioequivalent.

Start Date15 Jan 2018

Sponsor / Collaborator

Chongqing Huapont Pharmaceutical Co. Ltd.

CTR20171464

/ CompletedNot Applicable

对氨基水杨酸肠溶颗粒的随机、开放、单次给药、双周期、双交叉空腹预BE试验

[Translation] A randomized, open-label, single-dose, two-period, double-crossover fasting pre-BE trial of p-aminosalicylic acid enteric-coated granules

以重庆华邦制药有限公司生产的对氨基水杨酸肠溶颗粒为受试制剂，与JACOBUS PHARMACEUTICAL公司生产的对氨基水杨酸肠溶颗粒（商品名：PASER）进行人体生物利用度与生物等效性试验，比较受试制剂和参比制剂是否生物等效。

[Translation]

The p-aminosalicylic acid enteric-coated granules produced by Chongqing Huabang Pharmaceutical Co., Ltd. were used as the test preparation, and a human bioavailability and bioequivalence study was conducted with p-aminosalicylic acid enteric-coated granules (trade name: PASER) produced by Jacobus Pharmaceutical to compare whether the test preparation and the reference preparation are bioequivalent.

Start Date13 Nov 2017

Sponsor / Collaborator

Chongqing Huapont Pharmaceutical Co. Ltd.

100 Clinical Results associated with Aminosalicylic acid

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100 Translational Medicine associated with Aminosalicylic acid

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100 Patents (Medical) associated with Aminosalicylic acid

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5,100

Literatures (Medical) associated with Aminosalicylic acid

01 Mar 2025·Chemistry & Biodiversity

In Silico and In Vitro Evaluation of Quinoline Derivatives as Potential Inhibitors of AChE, BACE1, and GSK3β for Neurodegenerative Diseases Treatment

Article

Author: Assis de Oliveira, Bruno ; Glanzmann, Nícolas ; Mendonça de Assis, Pollyana ; Gonçalves de Oliveira, Filipe ; Rezende Barbosa Raposo, Nádia ; Zabala Capriles Goliatt, Priscila Vanessa ; de Assis Cruz, Otávio ; David da Silva, Adilson

AbstractNeurodegenerative diseases are characterized by the structural and functional loss of neurons, which impacts populations worldwide. Enzymes such as acetylcholinesterase (AChE), beta‐site APP cleaving enzyme‐1 (BACE1), and glycogen synthase kinase 3‐beta (GSK3β) are implicated in their progression. Therefore, developing compounds that inhibit these enzymes is relevant for treating these conditions. This study investigated the potential of quinoline analogs as multitarget enzyme inhibitors through in silico and in vitro assays. In silico analyses highlighted one of the derivatives as the most potent inhibitor for all proteins. In vitro assays confirmed that the quinoline derivatives modulated the activity of the three targets. The best derivative in silico also exhibited significant AChE inhibition of 94.6 %. For GSK3β and BACE1, four derivatives, with quinoline linked to the sulfonamide nitrogen, showed inhibition values above 40 %. Two of them demonstrated no cytotoxicity for human glioblastoma cell proliferation, and the most potent was noncytotoxic at 7.8 and 3.9 μg mL−1. In murine fibroblasts, the most potent derivative showed no cytotoxicity, unlike its effect on glioblastoma cells. Similarly, other derivatives were noncytotoxic at concentrations less than 62.5 μg mL−1. These findings highlight one of the derivatives as promising multitarget enzyme inhibitors for the treatment of neurodegenerative diseases.

01 Mar 2025·FEBS Open Bio

Antitubercular potential and pH‐driven mode of action of salicylic acid derivatives

Article

Author: Mies, Frédérique ; Shlyonsky, Vadim ; Forest, Emma ; Bolla, Jean‐Michel ; Crauste, Céline ; Santucci, Pierre ; Francis, Thomas ; Canaan, Stéphane ; Cavalier, Jean‐François ; Laudouze, Janïs

In the search for new antituberculosis drugs with novel mechanisms of action, we evaluated the antimycobacterial activity of a panel of eight phenolic acids against four pathogenic mycobacterial model species, including Mycobacterium tuberculosis. We demonstrated that salicylic acid (SA), as well as the iodinated derivatives 5‐iodo‐salicylic acid (5ISA) and 3,5‐diiodo‐salicylic acid (3,5diISA), displayed promising antitubercular activities. Remarkably, using a genetically encoded mycobacterial intrabacterial pH reporter, we describe for the first time that SA, 5ISA, 3,5diISA, and the anti‐inflammatory drug aspirin (ASP) act by disrupting the intrabacterial pH homeostasis of M. tuberculosis in a dose‐dependent manner under in vitro conditions mimicking the endolysosomal pH of macrophages. In contrast, the structurally related second‐line anti‐TB drug 4‐aminosalicylic acid (PAS) had no pH‐dependent activity and was strongly antagonized by l‐methionine supplementation, thereby suggesting distinct modes of action. Finally, we propose that SA, ASP, and its two iodinated derivatives could restrict M. tuberculosis growth in a pH‐dependent manner by acidifying the cytosol of the bacilli, therefore making such compounds very attractive for further development of antibacterial agents.

01 Mar 2025·Analytical Biochemistry

Electrochemical sensing of dopamine using nanostructured silver chromate: Development of an IoT-integrated sensor

Article

Author: Kumari, Pooja ; Singh, Harishchandra ; Ghosh, Sarit K ; Saha, Chandan ; Mgenge, Lungelo ; Mallick, Kaushik

Dopamine, one of the most important neurotransmitters, plays a crucial role in the functions of human metabolism, as well as the cardiovascular, central nervous and hormonal systems. This study focuses on the synthesis of nanostructured silver chromate and their application in dopamine sensing. The nanoparticles were synthesized using a complexation-mediated route using aminosalicylic acid as a stabilizer, resulting in uniform particles ranging from 3 to 15 nm in size. The synthesized silver chromate was characterized using X-ray diffraction, transmission electron microscopy and X-ray photoelectron spectroscopy techniques. Electrochemical studies revealed that the silver chromate exhibit excellent catalytic activity for the detection of dopamine. The electroanalysis provided the selective recognition of dopamine with the limit of detection of 1.05 μM and sensitivity of 2.68 μA μM^-1 cm^-2 in a linear range of 5-45 μM. Additionally, a portable, IoT (internet of things)-integrated sensor based on the synthesized silver chromate was developed using Arduino Uno R4 Wi-Fi module, enabling real-time monitoring of dopamine with data transmission to a cloud platform.

100 Deals associated with Aminosalicylic acid

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External Link

KEGG	Wiki	ATC	Drug Bank
D00162	Aminosalicylic acid	J04AA01	DB00233

R&D Status

Approved

10 top approved records.

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Indication	Country/Location	Organization	Date
Tuberculosis, Multidrug-Resistant	Norway	Eurocept International B.V.	07 Apr 2014
Tuberculosis, Multidrug-Resistant	Liechtenstein	Eurocept International B.V.	07 Apr 2014
Tuberculosis, Multidrug-Resistant	Iceland	Eurocept International B.V.	07 Apr 2014
Tuberculosis, Multidrug-Resistant	European Union	Eurocept International B.V.	07 Apr 2014

Developing

10 top R&D records.

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Indication	Highest Phase	Country/Location	Organization	Date
Crohn Disease	Preclinical	Israel	Jacobus Pharmaceutical Co., Inc.	01 Jan 2007
Crohn Disease	Preclinical	United States	Jacobus Pharmaceutical Co., Inc.	01 Jan 2007

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Clinical Result

Indication

Phase

Evaluation

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


NCT00495521 (CTgov)	Phase 2	Crohn Disease	2	4-Aminosalicylic acid extended release granules (Active)	xgenprcgbm(tbvazkocfj) = emuhakfaoy itghdffofi (tokgnmfuro, obgfoizyzr - mruoixxneu) View more	-	21 Sep 2017
				4-Aminosalicylic acid extended release granules (Placebo)	xgenprcgbm(tbvazkocfj) = rdhiayvxxo itghdffofi (tokgnmfuro, oebixetvde - bvtjsjkwvu) View more