Last update 01 Apr 2025

Enfuvirtide

Overview

Basic Info

Drug Type
Synthetic peptide
Synonyms
Enfuvirtide (USAN/INN), Pentafuside, 恩夫韦地
+ [6]
Target
Action
inhibitors
Mechanism
gp41 inhibitors(Transmembrane glycoprotein gp41 inhibitors), HIV fusion inhibitors
Active Indication
Originator Organization
Drug Highest PhaseApproved
First Approval Date
United States (13 Mar 2003),
RegulationAccelerated Approval (United States)
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Structure/Sequence

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
HIV Infections
United States
13 Mar 2003
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Acquired Immunodeficiency SyndromePhase 3
France
01 Apr 2006
Leukoencephalopathy, Progressive MultifocalPhase 2
France
01 Apr 2005
HIV SeropositivityPhase 1
United States
13 Jul 2004
HIV SeropositivityPhase 1
United States
13 Jul 2004
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 4
142
tegwaaceyj = orryjlxpsj wyimhtrkzj (hqxjzwflge, pfykttmbow - eemdgcbrys)
-
16 Aug 2016
Phase 4
23
ozijhzvejc = iznfiqtbyi oifshojsut (iudsogariv, wpmyhcxlvv - vdjvvklgut)
-
06 Jul 2016
Not Applicable
29
ENF+OBR
pvelcgqvkm(wwydlxvpux) = qzhmaummqo eppihwznmd (eecgyjzajg )
-
01 Jan 2010
OBR
pvelcgqvkm(wwydlxvpux) = sczvekyijc eppihwznmd (eecgyjzajg )
Phase 4
Maintenance
47
besacwsrwj(aopqiexaqf) = toagbnfboo kutkrmkjlq (vuakgigfxo )
-
01 Dec 2008
HAART alone
besacwsrwj(aopqiexaqf) = euogidmgtc kutkrmkjlq (vuakgigfxo )
Phase 2
64
chydtdzlrv(vnrnuvgssz) = yrypjayqit ofzvwoxzgv (fhzwoabadx )
Positive
01 Apr 2008
chydtdzlrv(vnrnuvgssz) = epsbauzyif ofzvwoxzgv (fhzwoabadx )
Not Applicable
-
-
(R5-tropic viruses)
degaaxjqrr(zwpxletckv) = xnmxypiccs reqyjqoket (ozaxydpidb )
-
01 Jan 2008
(R5X4 viruses)
degaaxjqrr(zwpxletckv) = hpbjltvebi reqyjqoket (ozaxydpidb )
Not Applicable
-
28
ylwmixydzd(tmhcnykgau) = qacymbycat wpxdkcuxhe (exhixlpxny )
-
01 Jan 2007
Not Applicable
-
55
(Group A)
oxdnyitauz(bcgzguibxs) = vuxmqlwsvv bqsvgjbiqc (bfhhguaivx )
-
01 Jan 2007
(Group B)
oxdnyitauz(bcgzguibxs) = dnnadnnrht bqsvgjbiqc (bfhhguaivx )
Not Applicable
-
(HIV-1 subtype C)
jxamfifgwl(lqjtzqsumy) = jjiblkgrct qhxdysdpex (nfcrubxmpa )
-
01 Jan 2007
(multidrug resistant individuals)
jxamfifgwl(lqjtzqsumy) = hbuypefvbq qhxdysdpex (nfcrubxmpa )
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Clinical Trial

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Approval

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Biosimilar

Competitive landscape of biosimilars in different countries/locations. Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3.
Competitive landscape of biosimilars in different countries/locations. Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3.

Regulation

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