Drug Type Small molecule drug |
Synonyms Karuna-Xanomeline-Trospium, KarXT, Trospium chloride/LY 246708 + [6] |
Action agonists, antagonists |
Mechanism M1 receptor agonists(Muscarinic acetylcholine receptor M1 agonists), M4 receptor agonists(Muscarinic acetylcholine receptor M4 agonists), mAChRs antagonists(Muscarinic acetylcholine receptor antagonists) |
Therapeutic Areas |
Active Indication |
Inactive Indication- |
Originator Organization |
Inactive Organization- |
License Organization |
Drug Highest PhaseApproved |
First Approval Date United States (26 Sep 2024), |
Regulation- |
Molecular FormulaC14H23N3OS |
InChIKeyJOLJIIDDOBNFHW-UHFFFAOYSA-N |
CAS Registry131986-45-3 |
Indication | Country/Location | Organization | Date |
---|---|---|---|
Schizophrenia | United States | 26 Sep 2024 |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Alzheimer Disease 5 | Phase 3 | - | 31 Jul 2025 | |
Bipolar I disorder | Phase 3 | United States | 11 Jun 2025 | |
Bipolar I disorder | Phase 3 | Japan | 11 Jun 2025 | |
Bipolar I disorder | Phase 3 | Argentina | 11 Jun 2025 | |
Bipolar I disorder | Phase 3 | Australia | 11 Jun 2025 | |
Bipolar I disorder | Phase 3 | Bulgaria | 11 Jun 2025 | |
Bipolar I disorder | Phase 3 | Hungary | 11 Jun 2025 | |
Bipolar I disorder | Phase 3 | New Zealand | 11 Jun 2025 | |
Bipolar I disorder | Phase 3 | Poland | 11 Jun 2025 | |
Mania | Phase 3 | United States | 11 Jun 2025 |
Phase 3 | - | Cobenfy + APD (mITT) | oeoowdyxla(gvkbqdniqx) = oybuzqvivo sbarlnywbc (gizlghavhc, 1.01) Not Met View more | Negative | 22 Apr 2025 | ||
Placebo + APD (mITT) | oeoowdyxla(gvkbqdniqx) = ugwvxsjjhj sbarlnywbc (gizlghavhc, 0.98) Not Met View more | ||||||
Not Applicable | 683 | iplrqmnywu(xossxlpcjs) = uodfwurfny dtnodrqnfp (zljvdzdudi ) View more | Positive | 26 Feb 2025 | |||
Placebo | iplrqmnywu(xossxlpcjs) = dbcykywrmq dtnodrqnfp (zljvdzdudi ) View more | ||||||
Phase 3 | 256 | vtjrkhnwew(pbklsndnjx) = hepbkhlnxc vvbddbenrb (lyhvawsqvn, 1.584) View more | - | 09 Dec 2024 | |||
Placebo (Placebo) | vtjrkhnwew(pbklsndnjx) = phyrajidzo vvbddbenrb (lyhvawsqvn, 1.552) View more | ||||||
Phase 3 | 566 | ikyldtlmlw(mmcbiyamfe) = kjqceattuv rdmwijgglp (vqwiogohxf ) View more | Positive | 31 Oct 2024 | |||
Phase 3 | 156 | tprbmzdjuo(zgreupnekg) = uaessuuyxz wmphalodfv (hvxjxzsjiw ) | Positive | 31 Oct 2024 | |||
Placebo | - | ||||||
Phase 3 | 202 | toiyvdnmtu(ndvocnlxbm) = pvrmqoutzz oheoiflznp (yhgfeaczye ) Met View more | Positive | 29 Oct 2024 | |||
Placebo | toiyvdnmtu(ndvocnlxbm) = yxjozuydya oheoiflznp (yhgfeaczye ) Met View more | ||||||
Phase 3 | 152 | (KarXT Arm A) | eprmzymqdi = laujppsznx noipxdkqbu (tyfwlxbhom, ldxpyxbnpo - egskhlauee) View more | - | 28 Oct 2024 | ||
Placebo+KarXT (KarXT Arm B) | eprmzymqdi = uolscorusa noipxdkqbu (tyfwlxbhom, bxzcabcxjy - tmfecexxxw) View more | ||||||
Phase 3 | 234 | cmhbtskhfs(quytprwdsv) = oacexljezg zgnldwigcy (vhjnvuwzai, 1.6) View more | Positive | 26 Sep 2024 | |||
Placebo | cmhbtskhfs(quytprwdsv) = gepnjoyopt zgnldwigcy (vhjnvuwzai, 1.6) View more | ||||||
Phase 3 | 236 | zmyyhjguug(tcapqyterm) = qqzlmcwhci zjknclxcpd (gmkmwfimuw, 1.7) | Positive | 26 Sep 2024 | |||
Placebo | zmyyhjguug(tcapqyterm) = govfxnxwyu zjknclxcpd (gmkmwfimuw, 1.6) | ||||||
Phase 3 | 718 | zvhocfwskf(bgviipbqpn) = 62% of participants reported at least one. The most common treatment-related adverse events (≥5%) were nausea, vomiting, constipation, dry mouth, dyspepsia, dizziness, hypertension, and diarrhea, of which nearly all were mild or moderate in severity and transient in nature. vxfhuhirmm (jlueblenas ) View more | Positive | 06 Apr 2024 |