Last update 30 Jun 2025

Xanomeline Tartrate/Trospium Chloride

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Karuna-Xanomeline-Trospium, KarXT, Trospium chloride/LY 246708
+ [6]
Action
agonists, antagonists
Mechanism
M1 receptor agonists(Muscarinic acetylcholine receptor M1 agonists), M4 receptor agonists(Muscarinic acetylcholine receptor M4 agonists), mAChRs antagonists(Muscarinic acetylcholine receptor antagonists)
Inactive Indication-
Originator Organization
Inactive Organization-
Drug Highest PhaseApproved
First Approval Date
United States (26 Sep 2024),
Regulation-
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Structure/Sequence

Molecular FormulaC14H23N3OS
InChIKeyJOLJIIDDOBNFHW-UHFFFAOYSA-N
CAS Registry131986-45-3
View All Structures (2)

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Schizophrenia
United States
26 Sep 2024
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Alzheimer Disease 5Phase 3-31 Jul 2025
Bipolar I disorderPhase 3
United States
11 Jun 2025
Bipolar I disorderPhase 3
Japan
11 Jun 2025
Bipolar I disorderPhase 3
Argentina
11 Jun 2025
Bipolar I disorderPhase 3
Australia
11 Jun 2025
Bipolar I disorderPhase 3
Bulgaria
11 Jun 2025
Bipolar I disorderPhase 3
Hungary
11 Jun 2025
Bipolar I disorderPhase 3
New Zealand
11 Jun 2025
Bipolar I disorderPhase 3
Poland
11 Jun 2025
ManiaPhase 3
United States
11 Jun 2025
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
-
Cobenfy + APD
(mITT)
oeoowdyxla(gvkbqdniqx) = oybuzqvivo sbarlnywbc (gizlghavhc, 1.01)
Not Met
Negative
22 Apr 2025
Placebo + APD
(mITT)
oeoowdyxla(gvkbqdniqx) = ugwvxsjjhj sbarlnywbc (gizlghavhc, 0.98)
Not Met
Not Applicable
683
iplrqmnywu(xossxlpcjs) = uodfwurfny dtnodrqnfp (zljvdzdudi )
Positive
26 Feb 2025
Placebo
iplrqmnywu(xossxlpcjs) = dbcykywrmq dtnodrqnfp (zljvdzdudi )
Phase 3
256
vtjrkhnwew(pbklsndnjx) = hepbkhlnxc vvbddbenrb (lyhvawsqvn, 1.584)
-
09 Dec 2024
Placebo
(Placebo)
vtjrkhnwew(pbklsndnjx) = phyrajidzo vvbddbenrb (lyhvawsqvn, 1.552)
Phase 3
566
ikyldtlmlw(mmcbiyamfe) = kjqceattuv rdmwijgglp (vqwiogohxf )
Positive
31 Oct 2024
Phase 3
156
tprbmzdjuo(zgreupnekg) = uaessuuyxz wmphalodfv (hvxjxzsjiw )
Positive
31 Oct 2024
Placebo
-
Phase 3
202
toiyvdnmtu(ndvocnlxbm) = pvrmqoutzz oheoiflznp (yhgfeaczye )
Met
Positive
29 Oct 2024
Placebo
toiyvdnmtu(ndvocnlxbm) = yxjozuydya oheoiflznp (yhgfeaczye )
Met
Phase 3
152
(KarXT Arm A)
eprmzymqdi = laujppsznx noipxdkqbu (tyfwlxbhom, ldxpyxbnpo - egskhlauee)
-
28 Oct 2024
Placebo+KarXT
(KarXT Arm B)
eprmzymqdi = uolscorusa noipxdkqbu (tyfwlxbhom, bxzcabcxjy - tmfecexxxw)
Phase 3
234
cmhbtskhfs(quytprwdsv) = oacexljezg zgnldwigcy (vhjnvuwzai, 1.6)
Positive
26 Sep 2024
Placebo
cmhbtskhfs(quytprwdsv) = gepnjoyopt zgnldwigcy (vhjnvuwzai, 1.6)
Phase 3
236
zmyyhjguug(tcapqyterm) = qqzlmcwhci zjknclxcpd (gmkmwfimuw, 1.7)
Positive
26 Sep 2024
Placebo
zmyyhjguug(tcapqyterm) = govfxnxwyu zjknclxcpd (gmkmwfimuw, 1.6)
Phase 3
718
zvhocfwskf(bgviipbqpn) = 62% of participants reported at least one. The most common treatment-related adverse events (≥5%) were nausea, vomiting, constipation, dry mouth, dyspepsia, dizziness, hypertension, and diarrhea, of which nearly all were mild or moderate in severity and transient in nature. vxfhuhirmm (jlueblenas )
Positive
06 Apr 2024
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Regulation

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