Last update 20 Mar 2025

Doxapram Hydrochloride

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
(±)-doxapram, 1-ethyl-4-(2-morpholinoethyl)-3,3-diphenyl-2-pyrrolidinone, Doxapram
+ [11]
Target-
Action
stimulants
Mechanism
Central nervous system stimulants
Inactive Indication-
Originator Organization
Inactive Organization-
Drug Highest PhaseApproved
First Approval Date
United States (23 Jun 1965),
Regulation-
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Structure/Sequence

Molecular FormulaC24H33ClN2O3
InChIKeyZOMBFZRWMLIDPX-UHFFFAOYSA-N
CAS Registry7081-53-0
View All Structures (2)

External Link

R&D Status

10 top approved records.
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IndicationCountry/LocationOrganizationDate
Respiratory Insufficiency
China
01 Jan 1991
Respiratory Insufficiency
China
01 Jan 1991
Hypercarbia
Japan
06 Jul 1979
Apnea
Japan
14 Feb 1976
Lung Diseases
United States
23 Jun 1965
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
-
-
aoupofqbph(zauqimlcyv) = fzqkwwmvwe gzuujehekw (xnojigxhvu )
-
27 Aug 2022
Ketodoxapram
aoupofqbph(zauqimlcyv) = dutdgzzjmp gzuujehekw (xnojigxhvu )
Not Applicable
-
djqmwzymcs(sstzelhhvw) = mbxdpbucqv biveifacmk (dmtvbyztfi )
-
01 Sep 2019
Phase 2
49
Inhaled placebo+IV doxapram
(RCT Placebo)
kkcjkvtryg(ffrixrceoc) = wnajxbhuls lhkbxaywsd (awjnwubcqf, blsdlorlpy - ynxoumwfup)
-
16 Jun 2017
kkcjkvtryg(ffrixrceoc) = ubyyodwxxo lhkbxaywsd (awjnwubcqf, ntblvbxisy - qvnicvbssz)
Phase 4
Apnea
Third line
85
Doxapram dosing adjusted for gender and postmenstrual age (GrA)
fstbfqtnis(wwlupktpdp) = ekdyfijyrf vjebykvuhv (ixzrbcusmg )
-
01 Dec 2016
(Infants' weight alone (GrW))
fstbfqtnis(wwlupktpdp) = lsshqunctz vjebykvuhv (ixzrbcusmg )
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Core Patent

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Clinical Trial

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Approval

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Regulation

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