The effect of proactive therapy with tacrolimus and betamethasone butyrate on atopic dermatitis: Randomized placebo-controlled study - The effect of proactive therapy on atopic dermatitis: Randomized placebo-controlled study

Start Date01 Dec 2011

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100 Clinical Results associated with Betamethasone Butyrate Propionate

100 Translational Medicine associated with Betamethasone Butyrate Propionate

100 Patents (Medical) associated with Betamethasone Butyrate Propionate

704

Literatures (Medical) associated with Betamethasone Butyrate Propionate

01 Jun 2025·Marine Environmental Research

Organophosphate esters and phthalate esters in marine fishes from a coastal area of China: Occurrence, tissue distribution, trophic transfer, and human exposure

Article

Author: Su, Zi-Han ; Wang, Can ; Zhou, Xue ; He, Ming-Jing

Concern over the influences of constant addition of anthropogenic chemicals to the marine environment has attracted public attention. Organophosphate esters (OPEs) and phthalate esters (PAEs) were two emerging chemicals frequently added to a variety of products as flame retardants and plasticizers. However, limited information is available associated with their environmental behaviors in marine environment, and the tissue-specific bioaccumulation and biomagnification of OPEs and PAEs in fish remain subjects of ongoing debate. Hence, 12 OPE and 6 PA E analogues were analyzed in five marine fish species from the coast of Wenchang, Hainan province. The concentrations of Σ₁₂OPEs and Σ₆PAEs were in the range of 319-1790 ng/g lw and 400-1370 ng/g lw, respectively. Significantly negative correlations (p value < 0.05) were observed between the concentration of pollutants and their corresponding lipid contents of fish tissues. There were no obvious correlations between the logarithmic transformed concentrations of each OPE and PAE analogue with their corresponding Log K_OW value in fish tissues, but OPE and PAE concentrations were likely to reach the highest when Log K_OW values were around five. Significantly negative correlations (p value < 0.05) were found between logarithmic transformed concentrations of TCEP, TCP and BBP along with δ¹⁵N values in fish species, except for TDCIPP, TEHP and DBP which exhibited an increasing trend with the increasing of δ¹⁵N values. Furthermore, human exposure via fish intakes was assessed, and EDI ranged from 73.9 to 1910 ng/kg bw/day for ∑OPEs and 495-4550 ng/kg bw/day for ∑PAEs, respectively, which were both within the safe dose threshold, and the HI values of ΣOPEs and ΣPAEs were much lower than the boundary value of 1.00. This study contributes valuable insights into OPEs and PAEs present in marine organisms as well as robust evidence indicating that most OPE and PAE analogues undergo trophic dilution within marine fish.

01 Jun 2025·Chemosphere

Sources and characterisation of organic pollutants in airborne particle fractions in an urban area, Bab Ezzaour, Algeria: A focus on n-alkanes and polar substances

Article

Author: Teffahi, Amira ; Kerchich, Yacine ; Merabet, Hamza ; Cecinato, Angelo ; Romagnoli, Paola ; Ibrir, Abdellah

The main objective of this study was to determine the loads, sources and behaviour of n-alkanes and several polar organics, including plasticisers (phthalates, [bis]2-ethylhexyl adipate), psychotropic substances (both legal and illegal) and the mosquito repellent DEET, in the atmosphere of the city of Bab Ezzouar, northern Algeria. Particulate matter was classified into three fractions according to aerodynamic diameter: coarse (PM_10-2.5), fine (PM_2.5-1) and ultrafine (PM_1-0.01) particles. s. Particulate samples were collected from the atmosphere using a high-volume sampler (HVS), and target compounds were characterised using gas chromatography coupled with mass spectrometry detection (GC-MS) over a one-year period (January 2018 to January 2019). In detail, 41 organic compounds were analysed. The total content of n-alkanes, considering the three particle size fractions, was found to be 43.8 ± 18.0 ng/m³, while the phthalate reached 27.4 ± 13.6 ng/m³. The incremental risk to human health was assessed using a model in accordance with USEPA guidelines. The results indicate that the carcinogenic risk for BBP and DEHP were 1.49 × 10^-10 and 7.72 × 10^-8, respectively. The study of psychotropic substances revealed the occurrence of significant concentrations of nicotine and caffeine (up to tens of ng/m³), accompanied by cotinine and cannabinol. According to principal component analysis and three molecular indices (i.e. carbon preference index [CPI], carbon number of n-alkane maximum concentration [Cmax] and natural wax percentage [NW%]), PVC combustion and vehicle exhaust were the main sources of organic pollutants associated with airborne particles at Bab Ezzouar. Tabacco smoke and biogenic emissions (microorganisms/bacteria and high vegetation) contribute less to the formation of organic contaminants, although they cannot be ignored.

01 May 2025·Ecotoxicology and Environmental Safety

Evaluation of phthalates induced cardiotoxicity using human iPSCs-derived cardiomyocyte and dual-cardiotoxicity evaluation methods

Article

Author: Park, Jeong Hwan ; Kim, C-Yoon ; Shin, Hyewon ; Kim, Yoonseo ; Park, Shinhye ; Park, Sang Woong ; Lee, Yun Hyeong ; Kim, Min Woo ; Oh, Jeong-Seop ; Kim, Seeun ; Lee, Myeonghee ; Lee, Seul-Gi ; Jeong, Youngin ; Bae, Young Min ; Lee, Suemin ; Chung, Hyung Min

Phthalates, known as plasticizers, are endocrine disruptor, and their risks are being highlighted as their use increases worldwide. Di-2-ethylhexyl phthalate (DEHP), the most prevalent of the phthalates, is known to be toxic to humans, and it has recently been reported to be linked to cardiotoxicity. Although many other phthalates are also widely used, data on their cardiotoxic effects are yet to be well established. In this study, we assessed the cardiotoxic potential of various phthalates using human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) and a microelectrode array-based dual-cardiotoxicity evaluation method previously reported. Cytotoxicity results showed that acute exposure to DEHP, dibutyl phthalate (DBP), benzyl butyl phthalate (BBP), and di-n-octyl phthalate (DnOP) did not affect the viability of hiPSC-CMs. Before examining the functional changes in hiPSC-CMs caused by exposure to these four phthalates, we present changes in field potential (FP) and contractility based on the blocking of major ions for reference. Contrary to concerns, FP results showed a dramatic decrease in spike amplitude, beat period, and FP duration (FPD) at high doses of DBP and BBP rather than DEHP. Interestingly, DnOP resulted in a prolonged FPD, unlike the others. Furthermore, contractility results indicated that, unlike DEHP and DnOP, high doses of DBP and BBP caused beating arrest along with decreased beat amplitude. Overall, this study demonstrated that phthalates other than DEHP can also induce cardiotoxicity, even with acute exposure. It is expected that the application of the established evaluation method will facilitate the development of safe alternatives.

100 Deals associated with Betamethasone Butyrate Propionate

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KEGG	Wiki	ATC	Drug Bank
D02032	-	D07XC01 A07EA04 R01AD06 C05AA05 S03BA03 S01CB04 S01BA06 D07AC01 H02AB01 S02BA07 R03BA04	-

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Indication	Country/Location	Organization	Date
Psoriasis	Japan	-	03 Jan 1995
Cicatrix, Hypertrophic	-	-	-
Dermatitis	-	-	-
Eczema	-	-	-
Erythema	-	-	-
Exanthema	-	-	-
Keratosis, Seborrheic	-	-	-
Lichen Planus	-	-	-
Lupus Erythematosus, Discoid	-	-	-
Mycosis Fungoides	-	-	-
Pemphigoid, Bullous	-	-	-
Prurigo	-	-	-
Sarcoidosis	-	-	-

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