Last update 21 Nov 2024

Trastuzumab envedotin

Overview

Basic Info

Drug Type
Antibody drug conjugate (ADC)
Synonyms
+ [2]
Mechanism
HER2 antagonists(Receptor protein-tyrosine kinase erbB-2 antagonists), Tubulin inhibitors
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Structure

Molecular FormulaC18H29N5O4
InChIKeyVEGGTWZUZGZKHY-GJZGRUSLSA-N
CAS Registry159857-79-1
View All Structures (2)
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
HER2 Positive Breast CancerPhase 3
CN
11 Oct 2023
Advanced HER2-Positive Breast CarcinomaPhase 3-01 Jul 2023
HER2-expressing Gastric AdenocarcinomaPhase 2-26 Aug 2024
Metastatic Gastroesophageal Junction AdenocarcinomaPhase 2-26 Aug 2024
Metastatic Gastric CarcinomaPhase 2-01 Aug 2021
Recurrent Metastatic Gastric CarcinomaPhase 2-01 Aug 2021
Ovarian CancerPhase 2
CN
01 Jul 2021
Advanced gastric carcinomaPhase 1
CN
08 Jun 2021
Metastatic human epidermal growth factor 2 positive carcinoma of breastDiscovery-01 May 2022
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1
94
(avzmdvfbpr) = (Grade 3 eye pain) was observed at 4.0 mg/kg dose ddezuisrix (mmylbmxymh )
Positive
12 Sep 2024
Phase 1
94
(mtdhqdfjjv) = ocfhsnyvnh xwtodwubpy (jrmzotzdcv )
Positive
22 Oct 2023
(vxkimfldup) = xolpgkzmwj guwcbdcsit (brwctthamy )
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Translational Medicine

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Deal

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Core Patent

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Clinical Trial

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Approval

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Regulation

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