Delving into the Latest Updates on Methoxy Polyethylene Glycol-Epoetin Beta with Synapse

A randomized, observer blind, parallel-group, active controlled, single dose study to compare pharmacokinetic, pharmacodynamic, safety and immunogenicity of Pegylated Erythropoietin 100 mcg/0.3 ml injection (PEG-EPO) of Incepta and Methoxy Polyethylene Glycol-Epoetin Beta 100 micrograms/0.3 ml solution for injection of Roche (Mircera) in healthy adult human subjects. - NIL

Start Date21 Jan 2025

Sponsor / Collaborator

Incepta Pharmaceuticals Ltd.

[+1]

TCTR20190718006

/ RecruitingPhase 4IIT

A RANDOMIZED, CONTROLLED, OPEN-LABEL, SINGLE-CENTER, PARALLEL GROUP STUDY TO ASSESS THE EFFECT OF MIRCERA ON DELAYING DIALYSIS IN ANEMIC PATIENTS WITH STAGE 5 CHRONIC KIDNEY DISEASE NOT ON DIALYSIS

Start Date19 Mar 2019

Sponsor / Collaborator-

NCT03552393

/ CompletedPhase 2

An Open-Label, Single-Arm, Multicenter Study to Ascertain the Optimal Starting Dose of MIRCERA® Given Subcutaneously for the Maintenance Treatment of Anemia in Pediatric Patients With Chronic Kidney Disease on Dialysis or Not Yet on Dialysis.

Ascertain the starting dose of Mircera given subcutaneously for the maintenance treatment of anemia in pediatric participants with chronic kidney disease (CKD) on dialysis or not yet on dialysis when switching from stable subcutaneous (SC) maintenance treatment with epoetin alfa, epoetin beta, or darbepoetin alfa.

Start Date03 Aug 2018

Sponsor / Collaborator

Hoffmann-La Roche, Inc.

100 Clinical Results associated with Methoxy Polyethylene Glycol-Epoetin Beta

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100 Translational Medicine associated with Methoxy Polyethylene Glycol-Epoetin Beta

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100 Patents (Medical) associated with Methoxy Polyethylene Glycol-Epoetin Beta

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512

Literatures (Medical) associated with Methoxy Polyethylene Glycol-Epoetin Beta

31 Dec 2025·RENAL FAILURE

Effect of roxadustat on lowering blood lipids in peritoneal dialysis patients with anemia

Article

Author: Zang, Xiujuan ; Huang, Xiaomin ; Ma, Yuhua ; Zhang, Chunyan ; Ruan, Yilin ; Chen, Nan ; Wang, Yi ; Yu, Geping ; Xu, Tian ; Xie, Jingyuan ; Ren, Hong ; Qi, Hualin ; Mi, Xiuhua ; Liu, Na

OBJECTIVES:

To observe the effect of roxadustat on lowering blood lipids in peritoneal dialysis (PD) patients beyond treating anemia.

METHODS:

In a prospective, multicenter clinical study, we randomly assigned (in a 1:1 ratio) 100 PD patients who had received erythropoiesis-stimulating agent therapy for at least 4 weeks to receive either roxadustat or erythropoietin (EPO) for 48 weeks. The blood lipids, hemoglobin, blood pressure, blood glucose, iron metabolism and inflammatory factors were compared between the two groups at 0, 2, 4, 8, 12, 16, 20, 24 and 48 weeks, respectively.

RESULTS:

At start of switching to roxadustat, hemoglobin seemed to rise a little faster (102.8 ± 15.4 vs. 97.1 ± 17.3 g/L at 2 weeks, p > 0.05), but there was no significant difference in hemoglobin change between the two groups over the course of observation (p = 0.185). At the early stage of the study (12 weeks), the transferrin saturation (TSAT) of roxadustat group decreased significantly from the baseline (32.7 (20.6) vs. 22.1 (18.7)%, p = 0.001). At the end of the study period (48 weeks), total cholesterol (3.89 ± 0.92 vs. 4.52 ± 1.14 mmol/L, p = 0.012), low density lipoprotein cholesterol (2.24 ± 0.74 vs. 2.63 ± 0.82 mmol/L, p = 0.045) and triglyceride (1.35 (0.86) vs. 1.89 (1.27) mmol/l, p = 0.013) in roxadustat group were significantly lower than those in EPO group.

CONCLUSIONS:

Roxadustat not only can improve anemia and iron metabolism, but also can reduce serum cholesterol and triglyceride levels in PD patients after switching from the EPO.

14 Jul 2025·Oxford Medical Case Reports

Over eight years of transfusion independence with continuous erythropoietin receptor activator and Roxadustat in transfusion-dependent low-risk myelodysplastic syndrome

Article

Author: Kitamura, Tetsuya ; Furumatsu, Yoshiyuki ; Ikenoue, Tatsuyoshi

Abstract:

We report a case of a 65-year-old Japanese woman with low-risk myelodysplastic syndrome (MDS) on hemodialysis who achieved transfusion independence for over eight years with combined epoetin beta pegol (continuous erythropoietin receptor activator, CERA) and roxadustat. Transfusion-dependent since 2008, she showed a temporary response to darbepoetin and CERA, initiated in August 2016. Roxadustat was added in January 2020, leading to sustained transfusion independence. No serious adverse events, such as progression to acute leukemia or clinically significant thyroid dysfunction, were observed during this period.

01 Jul 2025·Drug Testing and Analysis

New Transcriptomic Biomarkers for Detection of the Recombinant Human Erythropoietin (rHuEPO) MirCERA in Horses

Article

Author: Delcourt, Vivian ; Loup, Benoit ; Popot, Marie‐Agnès ; André, François ; Leuenberger, Nicolas ; Bailly‐Chouriberry, Ludovic ; Marchand, Alexandre ; Barnabé, Agnès ; Garcia, Patrice

ABSTRACT:

Detection and monitoring of biomarkers related to doping is particularly suitable for the development of analytical strategies dedicated to indirect detection of banned substances. Previous studies in horses have already allowed the investigation of transcriptomic biomarkers in equine blood associated with reGH and rHuEPO administrations. Our most recent developments continue to focus on the discovery and monitoring of transcriptomic biomarkers for the control of ESAs, and a collaborative study with WADA‐accredited doping control laboratories has recently been initiated to conduct a pilot study. In humans, three mRNAs (ALAS2, CA1, and SLC4A1) were previously observed to be differentially expressed after blood doping and were associated with immature red blood cells, the so‐called circulating reticulocytes. In horses, circulating reticulocytes are rarely observed even after rHuEPO administration. With the improved primers that detect the equine orthologues of the human mRNAs from the ALAS2, CA1, and SLC4A1 genes, we can now report the first evidence of the detection of the three biomarkers in equine blood. In addition, an upregulation of the mRNA levels of the three genes was observed after analysis of blood samples collected from MirCERA‐treated animals, with kinetics similar to those previously documented in humans. Our data suggest that ALAS2 and CA1 are promising indirect biomarkers for the detection of recombinant EPO abuse in horses, as observed in humans.

12

News (Medical) associated with Methoxy Polyethylene Glycol-Epoetin Beta

24 Oct 2024

·www.prnewswire.com

Fresenius Medical Care Recent Study Validates Innovative Anemia Therapy Software Improves Clinical Outcomes for Hemodialysis Patients

This randomized controlled study demonstrates that patients achieved a higher percentage of target hemoglobin levels Patients receiving anemia management assistance via the software tools saw a 25% reduction in erythropoiesis-stimulating agent (ESA) usage The software's physiology-based model and predictive controller were associated with improved hemoglobin fluctuations and variability, offering a higher likelihood of more stable hemoglobin levels compared to standard care protocols BAD HOMBURG, Germany, Oct. 24, 2024 /PRNewswire/ -- Fresenius Medical Care (FME), the world's leading provider of products and services for individuals with renal diseases, today announced innovative results from a multicenter, randomized controlled trial in the United States that highlights the potential benefits of personalized anemia therapy for patients undergoing hemodialysis. The study, "Effects of Individualized Anemia Therapy on Hemoglobin Stability," published in the Clinical Journal of the American Society of Nephrology (CJASN), demonstrates that the use the anemia therapy assistance software, attained improved hemoglobin stability and reduced the use of erythropoiesis-stimulating agents (ESAs) among hemodialysis patients participating in the study1. This innovative approach, which is part of the company's ongoing commitment to improve patient outcomes, is powered by a physiology-driven mathematical model designed to deliver personalized treatment recommendations. The results showed a 25% improvement in hemoglobin target attainment for patients receiving individualized therapy compared to standard care. The findings are significant because maintaining target hemoglobin levels with less variability in patients can help reduce the risk of developing cardiovascular problems. "This study exemplifies how data-driven insights can lead to more personalized treatments," said Dr. Frank Maddux, MD, Chief Global Medical Officer of Fresenius Medical Care. "By integrating cutting-edge computational techniques, we are paving the way for more precise, patient-centered care, which not only improves clinical outcomes but also enhances quality of life for people on dialysis. Our commitment is to continue developing innovative solutions that transform kidney care worldwide." The study, conducted by Dr. Doris H. Fuertinger and colleagues, enrolled 96 patients from five Fresenius Kidney Care clinics across the United States. Patients were randomized into two groups: one receiving personalized anemia treatment recommendations from the software, and the other following standard protocols. Over a 26-week period, patients in the personalized therapy group achieved greater hemoglobin stability, experienced fewer fluctuations, and required significantly less ESA, reducing their dose on average by 25%. Additional key findings suggest hemoglobin variability was significantly lower in the personalized therapy group, contributing to more stable patient outcomes. "This prospective, randomized controlled study highlights the value of physiological models and computer-aided individualization of therapy to improve clinical outcomes for people on dialysis," said Dr. Fuertinger, Head of Computational Medicine, Fresenius Medical Care. "By harnessing the power of these technologies, we are able to provide clinicians with actionable insights that may enable more precise and efficient therapy management." The study underscores FME's vision of transforming renal care by designing cloud-based technologies and predictive analytics that can potentially integrate into daily clinical practice. As healthcare moves toward greater personalization, the company is committed to utilizing these advanced tools to optimize patient care and support clinicians in making data-driven decisions. "We are proud to be at the forefront of this important research by developing novel approaches to treat end-stage renal failure," said Dr. Katarzyna Mazur-Hofsaess, member of the Management Board of Fresenius Medical Care and responsible for the segment Care Enablement. "Our commitment to new technology continues to support the individualization of care for people living with kidney disease." For more information on Fresenius Medical Care's innovations and research in renal care, visit . About Fresenius Medical Care: Fresenius Medical Care is the world's leading provider of products and services for individuals with renal diseases of which around 4.1 million patients worldwide regularly undergo dialysis treatment. Through its network of 3,757 dialysis clinics, Fresenius Medical Care provides dialysis treatments for approx. 311,000 patients around the globe. Fresenius Medical Care is also the leading provider of dialysis products such as dialysis machines or dialyzers. Fresenius Medical Care is listed on the Frankfurt Stock Exchange (FME) and on the New York Stock Exchange (FMS). For more information visit the Company's website at . Disclaimer: This release contains forward-looking statements that are subject to various risks and uncertainties. Actual results could differ materially from those described in these forward-looking statements due to various factors, including, but not limited to, changes in business, economic and competitive conditions, legal changes, regulatory approvals, impacts related to the COVID-19 pandemic results of clinical studies, foreign exchange rate fluctuations, uncertainties in litigation or investigative proceedings, and the availability of financing. These and other risks and uncertainties are detailed in Fresenius Medical Care's reports filed with the U.S. Securities and Exchange Commission. Fresenius Medical Care does not undertake any responsibility to update the forward-looking statements in this release. 1 Fuertinger, Doris H., et al. "Effects of Individualized Anemia Therapy on Clinical Outcomes in Patients Undergoing Hemodialysis." Clinical Journal of the American Society of Nephrology, vol. 19, no. 9, 2024, pp. 1100-1110. Media contact Kirsten Stratton T +1 781 929 8096 [email protected] Christine Peters T +49 160 60 66 770 [email protected] Contact for analysts and investors Dr. Dominik Heger T +49 6172 609 2601 [email protected] SOURCE Fresenius Medical Care Holdings, Inc. WANT YOUR COMPANY'S NEWS FEATURED ON PRNEWSWIRE.COM? 440k+ Newsrooms & Influencers 9k+ Digital Media Outlets 270k+ Journalists Opted In GET STARTED

Clinical Result

13 Feb 2024

·www.businesswire.com

Injectable Hematology Growth Factors Report 2024 - Evolution in Therapeutic Care - ResearchAndMarkets.com

DUBLIN--( BUSINESS WIRE )--The "Injectable Hematology Growth Factors Report" has been added to ResearchAndMarkets.com's offering. This report is a comprehensive evaluation and analysis of the technology, products, and participants providing the driving force behind this evolving segment of the healthcare sector. The study is designed to provide drug company decision-makers, drug delivery developers, device designers, healthcare marketers, and supply chain participants with a detailed understanding of the economics, technologies, and opportunities for injection devices designed for patient self-administration. Provider organization business managers, healthcare administrators, and investors will also benefit from this study. Evolution in Therapeutic Care Several recombinant hematologic growth factors or agonists for their receptors have been produced that are useful in treating anemia, neutropenia, and thrombocytopenia, particularly in patients with end-stage renal disease or aplastic anemia or who have received cancer chemotherapy or a hematopoietic cell transplant. The shift in as-supplied packaging from single and multi-use vials to prefilled injection devices will accelerate over the next five years as drug developers move to empower an increasing number of chronically ill patients. The powerful physiological effects of antibodies, hormones, and other biological drugs also increase the need for safety and compliance. What You Will Learn Provides detailed analysis of injectable hematology growth factors delivery and device strategies, and product development factors. Assesses key markets, market dynamics, and market demographics. Analyzes therapeutic demand drivers and evaluates injectable drug products in a number of key therapeutic segments. Provides market data and forecasts. Profiles market sector participants, their product development activities, business strategies, and corporate alliances and affiliations Assesses the importance of alliances and partnerships on drug product commercialization. Evaluates the impact of economic, technology, and regulatory factors Key Topics Covered: Hematology Market Dynamics Competitive Factors Proliferation of Biological Drugs Product Manufacturers Hematology Growth Factors Devices for Administering Injectable Growth Factors Device Selection - Stability and Material Issues Competitive Landscape Prefilled Syringes Pen Injectors Dual Chamber Pens Emerging Devices Injectable Hematology Growth Factors - Product Assessment Abseamed Accofil Aranesp Binocrit Biograstim Biopoin Epoetin Alfa Hexal Eporatio Filgrastim Hexal Fulphila Granix Grastofil Mircera NeoRecormon Neulasta Neupogen Nivestim Ratiograstim Retacrit Rolvedon Silapo Tevagrastim Udenyca (Coherus BioSciences) Zarzio Ziextenzo Market Assessment Anemia Hematopoietic Stem Cell Transplant Advanced Kidney Disease Neutropenia Predonation of Autologous Blood Company Profiles Companies Mentioned AbZ-Pharma Accord Healthcare Amgen Genentech Hexal AG Medice Arzneimittel Mylan International Novartis Pfizer Ratiopharm Rentscler Biotechnologie Roche Sandoz Stada Arzneimittel AG Teva Pharmaceuticals For more information about this report visit https://www.researchandmarkets.com/r/bktosb About ResearchAndMarkets.com ResearchAndMarkets.com is the world's leading source for international market research reports and market data. We provide you with the latest data on international and regional markets, key industries, the top companies, new products and the latest trends.

ASH

09 Feb 2024

·www.prnewswire.com

Injectable Hematology Growth Factors Report: Shift in As-Supplied Packaging from Single and Multi-use Vials to Prefilled Injection Devices will Accelerate over the Next Five Years

DUBLIN, Feb. 9, 2024 /PRNewswire/ -- The "Injectable Hematology Growth Factors Report" has been added to ResearchAndMarkets.com's offering. Understanding the rapidly advancing sector of injectable hematology growth factors is crucial for stakeholders in the healthcare industry. The latest comprehensive report evaluates the intersection of technology, products, and key players that are shaping this dynamic segment, with particular emphasis on devices designed for patient self-administration. The study presents an in-depth examination of the evolving therapeutic care landscape, highlighting significant developments in the treatment of conditions such as anemia, neutropenia, and thrombocytopenia. It analyzes the shift from traditional vials to prefilled injection devices, a trend that is likely to gain momentum over the following five years, emphasizing the market forces driving this change. Key Highlights from the Report: An in-depth analysis of device strategies and product development factors influencing the injectable hematology growth factors delivery systems. Insight into market dynamics and demographics, underpinning industry growth. An evaluation of therapeutic demand drivers across pivotal segments in healthcare. Comprehensive market data and forecast trends to inform strategic decisions. Profiles of sector participants including business strategies and corporate associations. An assessment of how alliances and partnerships affect the commercialization of drug products. Insights into the economic, technological, and regulatory factors impacting the market. Healthcare administrators, investors, and other stakeholders will benefit from this study's findings that not only chart current market conditions but also project future industry directions. It serves as a critical resource for decision-makers aiming to understand and capitalize on the opportunities presented within this segment. The report's findings are pivotal for a broad spectrum of healthcare professionals, including pharmaceutical decision-makers, device developers, healthcare marketers, and supply chain entities. It is particularly geared towards empowering chronically ill patients and enhancing safety protocols through revolutionary drug delivery methods. Stakeholders are poised to gain substantial insights into the strategies propelling the adoption of injectable hematologic treatments, facilitating informed decisions that align with the compelling trends of self-administered therapeutic care. Discover the Future of Injectable Hematology Treatments As the healthcare industry continues its inexorable march towards more patient-centric and self-managed treatment options, understanding the nuances and intricacies of injectable hematology growth factor treatments becomes ever more critical. The recent report provides these vital insights, demarking a clear view of the path forward. Stay informed on the latest in healthcare advancements and market opportunities. For further information and to explore the depth of this report, interested parties are encouraged to delve into the comprehensive analysis that awaits them. Key Topics Covered: Hematology Market Dynamics Competitive Factors Proliferation of Biological Drugs Product Manufacturers Hematology Growth Factors Devices for Administering Injectable Growth Factors Device Selection - Stability and Material Issues Competitive Landscape Prefilled Syringes Pen Injectors Dual Chamber Pens Emerging Devices Injectable Hematology Growth Factors - Product Assessment Abseamed Accofil Aranesp Binocrit Biograstim Biopoin Epoetin Alfa Hexal Eporatio Filgrastim Hexal Fulphila Granix Grastofil Mircera NeoRecormon Neulasta Neupogen Nivestim Ratiograstim Retacrit Rolvedon Silapo Tevagrastim Udenyca (Coherus BioSciences) Zarzio Ziextenzo Market Assessment Anemia Hematopoietic Stem Cell Transplant Advanced Kidney Disease Neutropenia Predonation of Autologous Blood Company Profiles Companies Mentioned AbZ-Pharma Accord Healthcare Amgen Genentech Hexal AG Medice Arzneimittel Mylan International Novartis Pfizer Ratiopharm Rentscler Biotechnologie Roche Sandoz Stada Arzneimittel AG Teva Pharmaceuticals For more information about this report visit About ResearchAndMarkets.com ResearchAndMarkets.com is the world's leading source for international market research reports and market data. We provide you with the latest data on international and regional markets, key industries, the top companies, new products and the latest trends. Media Contact: Research and Markets Laura Wood, Senior Manager [email protected] For E.S.T Office Hours Call +1-917-300-0470 For U.S./CAN Toll Free Call +1-800-526-8630 For GMT Office Hours Call +353-1-416-8900 U.S. Fax: 646-607-1907 Fax (outside U.S.): +353-1-481-1716 Logo: SOURCE Research and Markets

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100 Deals associated with Methoxy Polyethylene Glycol-Epoetin Beta

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KEGG	Wiki	ATC	Drug Bank
-	Methoxy Polyethylene Glycol-Epoetin Beta	B03XA03	DB09107

R&D Status

Approved

10 top approved records.

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Indication	Country/Location	Organization	Date
Anemia	China	Roche Pharma (Schweiz) AG	28 Apr 2018
Anemia of renal disease	Japan	Chugai Pharmaceutical Co., Ltd.	22 Apr 2011
Anemia in chronic kidney disease	Australia	Roche Products Pty Ltd.	28 Jul 2009
chronic renal failure anemia	European Union	Roche Registration GmbH	20 Jul 2007
chronic renal failure anemia	Iceland	Roche Registration GmbH	20 Jul 2007
chronic renal failure anemia	Liechtenstein	Roche Registration GmbH	20 Jul 2007
chronic renal failure anemia	Norway	Roche Registration GmbH	20 Jul 2007

Developing

10 top R&D records.

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Indication	Highest Phase	Country/Location	Organization	Date
Chronic kidney disease, Stage V	Phase 3	United States	Hoffmann-La Roche, Inc.	01 Mar 2007
Peritoneal dialysis complication	Phase 3	Japan	Chugai Pharmaceutical Co., Ltd.	01 Feb 2007
Nephrosis	Phase 3	Japan	Chugai Pharmaceutical Co., Ltd.	01 Jan 2007
Chronic Kidney Diseases	Phase 3	United States	Hoffmann-La Roche, Inc.	01 Feb 2004
Chronic Kidney Diseases	Phase 3	Brazil	Hoffmann-La Roche, Inc.	01 Feb 2004
Chronic Kidney Diseases	Phase 3	Canada	Hoffmann-La Roche, Inc.	01 Feb 2004
Chronic Kidney Diseases	Phase 3	Czechia	Hoffmann-La Roche, Inc.	01 Feb 2004
Chronic Kidney Diseases	Phase 3	France	Hoffmann-La Roche, Inc.	01 Feb 2004
Chronic Kidney Diseases	Phase 3	Germany	Hoffmann-La Roche, Inc.	01 Feb 2004
Chronic Kidney Diseases	Phase 3	Greece	Hoffmann-La Roche, Inc.	01 Feb 2004

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Clinical Result

Indication

Phase

Evaluation

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


MH40258 (ERA2022)	Not Applicable	Anemia in chronic kidney disease	229	C.E.R.A. (Continuous Erythropoietin Receptor Activator—Methoxy Polyethylene Glycol Epoetin Beta) (Peritoneal Dialysis (PD))	qyqowkcjsj(jgiuacqhii) = 121 PD patients (68%) and 36 HD patients (69%) had ≥ 1 hospitalization, of whom 102/121 (84%) and 32/36 (89%), respectively, had non-elective hospitalizations. Median hospitalization surveillance time/patient was 13.5 months in the PD and 18.3 months in the HD cohorts. The most frequent causes for non-elective hospitalization were infections, reported as a cause in 56/177 (32%) patients in the PD cohort and 14/52 (27%) in the HD cohort and technique complications, in 41/177 (23%) patients in the PD cohort and 20/52 (38%) in the HD cohort. dukzsstkdq (fnzzufjgys ) View more	Positive	03 May 2022
				C.E.R.A. (Continuous Erythropoietin Receptor Activator—Methoxy Polyethylene Glycol Epoetin Beta) (Hemodialysis (HD))
NCT03552393 (SKIPPER, ERA2022)	Phase 2	Anemia in chronic kidney disease Maintenance	-	C.E.R.A. SC every 4 weeks	yssgckzpmu(szxuhzntxw) = tzcircpkzp wubzeuuyuh (rzhpaunnig, 1.03) View more	Positive	03 May 2022
NCT03552393 (SKIPPER, CTgov)	Phase 2	Anemia \| chronic renal failure anemia \| Chronic Kidney Diseases	40	Mircera	pnyttollxs(rtoymaohrr) = rrlynwwxru kugxuenfaj (qdvhhoqsgp, 0.51) View more	-	07 Mar 2022
NCT00773513 (Pubmed \| Clin J Am Soc Nephrol)	Phase 4	Anemia in chronic kidney disease	2,818	Methoxy Polyethylene Glycol-Epoetin Beta	piciqbkbdx(tefngadjbc): HR = 1.06 (95% CI, 0.94 - 1.19) View more	-	06 Dec 2019
				Reference Erythropoiesis-Stimulating Agents
NCT01519947 (ALTITUD \| ALTITUDE, CTgov)	Phase 4	chronic renal failure anemia	87	Methoxy polyethylene glycol-epoetin beta (Pre-dialysis, Sea Level)	hwpzvilvur(nbmbflfzmy) = tjtbevigev jzasvqucrc (nvxfywzspl, 69.0) View more	-	27 Dec 2018
				Methoxy polyethylene glycol-epoetin beta (Dialysis, Sea Level)	hwpzvilvur(nbmbflfzmy) = yidomxaxyi jzasvqucrc (nvxfywzspl, 214.2) View more
NCT00773513 (CTgov)	Phase 4	Cardiovascular Diseases \| chronic renal failure anemia	2,825	methoxy polyethylene glycol-epoetin beta+Epoetin Beta+Darbepoetin Alfa (Erythropoiesis Stimulating Agents)	slzsjrixyi(tpeckfmytn) = qzjxgxhkqn jrgqlrsknm (emiitrfuqy, nwvcrvwojf - wknmnyirhn) View more	-	15 Aug 2018
				methoxy polyethylene glycol-epoetin beta+Epoetin Alfa+Darbepoetin Alfa (Methoxy Polyethylene Glycol-Epoetin Beta)	slzsjrixyi(tpeckfmytn) = voxxjtcocv jrgqlrsknm (emiitrfuqy, rvecygzkux - jvvjckhunk) View more
NCT00717366 (Pubmed \| Clin J Am Soc Nephrol) Manual	Phase 2	Chronic Kidney Diseases	64	methoxy polyethylene glycol-epoetin beta	rqwlkzywkm(rnrnjpdkeu) = hekqldchzn oahwbdvqaz (uirrukwtub, -0.45 to 0.26) View more	Positive	06 Jan 2018
NCT00717366 (NH19707, CTgov)	Phase 2	Anemia of renal disease \| chronic renal failure anemia \| Chronic Kidney Diseases	64	Methoxy Polyethylene Glycol-Epoetin Beta (MIRCERA Group 1: Intermediate-Conversion-Factor Group)	nxwnwmydze(nrzjkoxfct) = bnfcbufnpq errkwyqjsn (uuywqmcixj, 0.496) View more	-	08 Sep 2017
				Methoxy Polyethylene Glycol-Epoetin Beta (MIRCERA Group 2: High-Conversion-Factor Group)	nxwnwmydze(nrzjkoxfct) = mtynixasrv errkwyqjsn (uuywqmcixj, 0.493) View more
NCT01194154 (Pubmed \| Nephrol Dial Transplant) Manual	Phase 2	Chronic Kidney Diseases	235	erythropoiesis-stimulating agents	evpoukqyaj(oocnrstrqa) = odpgysazka pphypqvflj (adtpejrbbd, -2.2 to 3.8) View more	Negative	01 Feb 2017
				Placebo	evpoukqyaj(oocnrstrqa) = jcyhmxispf pphypqvflj (adtpejrbbd, -2.0 to 3.2) View more
NCT00394953 (CTgov)	Phase 3	Anemia \| chronic renal failure anemia \| Chronic Kidney Diseases	490	methoxy polyethylene glycol-epoetin beta [Mircera] (MIRCERA)	uybeuszbzk = stztjjpbsp dsrhgdhchd (xdtkcttobz, zoxtvwqdge - krfmgaxkod) View more	-	20 Jan 2017
				Darbepoetin alfa (Darbepoetin Alfa)	uybeuszbzk = jandhflakr dsrhgdhchd (xdtkcttobz, tnluydlntk - qnaxpqyfnp) View more

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