Last update 31 Oct 2024

S-81694

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
N-(2,6-diethyphenyl)-8-({4-[4-(dimethylamino)piperidin-1-yl]-2- methoxyphenyl}amino)-1-methyl-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide phosphate, NMS 01940153E, NMS P153
+ [5]
Mechanism
RPS27 inhibitors(ribosomal protein S27 inhibitors), TTK inhibitors(Dual specificity protein kinase TTK inhibitors)
Originator Organization
Drug Highest PhasePhase 2
First Approval Date-
RegulationOrphan Drug (US)
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Structure

Molecular FormulaC35H39F3N8O3
InChIKeyJFOAJUGFHDCBJJ-UHFFFAOYSA-N
CAS Registry1202055-32-0

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Unresectable Hepatocellular CarcinomaPhase 2
US
13 Nov 2020
Unresectable Hepatocellular CarcinomaPhase 2
IT
13 Nov 2020
Unresectable Hepatocellular CarcinomaPhase 2
ES
13 Nov 2020
Metastatic breast cancerPhase 2
JP
04 Jan 2018
Metastatic breast cancerPhase 2
JP
04 Jan 2018
Metastatic breast cancerPhase 2
BE
04 Jan 2018
Metastatic breast cancerPhase 2
BE
04 Jan 2018
Metastatic breast cancerPhase 2
FR
04 Jan 2018
Metastatic breast cancerPhase 2
FR
04 Jan 2018
Metastatic breast cancerPhase 2
NL
04 Jan 2018
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1/2
-
NMS-01940153E (NMS-153)
bdjngvtezu(oaxdkxoosh) = usrzwmyhtr flsboaxoch (kqgperlbmk )
Positive
20 Apr 2023
Not Applicable
-
eyralqjhxf(cqqcdnnurb) = hqzltzqdqa mhrznexymz (jfdpqkedqe )
Positive
28 Oct 2022
Phase 1/2
12
(dose-finding)
dpenjtepuw(fbkdcpzyox) = pdgdtnhgto dskwfvcora (pvserwqzlo )
Positive
28 Oct 2022
Phase 1
38
yfbebwucdc(ggrzntklhn) = jciwfzxqzf sqicthdxap (fqnrzhxvja )
-
11 May 2022
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Clinical Trial

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Approval

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Regulation

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