Last update 27 Apr 2025

Bempedoic acid

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Bempedoic acid (USAN/INN), Nilemdo, 贝派度酸
+ [3]
Target
Action
inhibitors
Mechanism
ACL inhibitors(ATP-citrate synthase inhibitors)
Originator Organization
Inactive Organization-
Drug Highest PhaseApproved
First Approval Date
RegulationOrphan Drug (United States)
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Structure/Sequence

Molecular FormulaC19H36O5
InChIKeyHYHMLYSLQUKXKP-UHFFFAOYSA-N
CAS Registry738606-46-7

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Cardiovascular Diseases
United States
22 Mar 2024
Myocardial Infarction
United States
22 Mar 2024
Primary Hyperlipidemia
United States
22 Mar 2024
Dyslipidemias
European Union
01 Apr 2020
Dyslipidemias
Iceland
01 Apr 2020
Dyslipidemias
Liechtenstein
01 Apr 2020
Dyslipidemias
Norway
01 Apr 2020
Primary hypercholesterolemia
European Union
01 Apr 2020
Primary hypercholesterolemia
Iceland
01 Apr 2020
Primary hypercholesterolemia
Liechtenstein
01 Apr 2020
Primary hypercholesterolemia
Norway
01 Apr 2020
Atherosclerosis
United States
21 Feb 2020
Heterozygous familial hypercholesterolemia
United States
21 Feb 2020
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
HypercholesterolemiaNDA/BLA
Japan
26 Nov 2024
Hyper LDL cholesterolaemiaPhase 3
Japan
13 Feb 2023
HyperlipidemiasPhase 3
United States
23 Oct 2017
HypertensionPhase 2
United States
16 Jun 2014
Diabetes Mellitus, Type 2Phase 2
United States
01 Apr 2012
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
96
Placebo
qemkqynqvp(aoybwzdlsj) = lfqhfkmccq pzczypbdjo (zebftgkcmj, 1.901)
-
13 Mar 2025
Phase 3
6,177
Bempedoic Acid 180 mg
ifsczjored(hjjbgwlnsn) = xqukpjxmno ziifvdltjp (wbqqzfdzil, 0.76 [0.63 - 0.92])
Positive
18 Feb 2025
Placebo
-
Not Applicable
-
ykbxajnphn(rtpxzswoqk): OR = 0.84 (95% CI, 0.76 - 0.96)
Positive
30 Aug 2024
Placebo
Not Applicable
7,475
kvwnjnfvak(yzrytpqwjn) = bbjsnlxnnl wmkjtsacpp (izhfyvdujq, -37.56 to -22.82)
Positive
01 Jun 2024
Phase 3
96
qwediarrot(hvqpbwhtsv) = toqpjqacel ezknvampwf (giofroelqd )
Met
Positive
20 May 2024
Placebo
qwediarrot(hvqpbwhtsv) = fqmvkwsxtx ezknvampwf (giofroelqd )
Met
Phase 2
188
Placebo
tidnjylmix(inljyvubcv) = qxdvkzktjk gegbvwlgjo (nxspxnvocf, 2.117)
-
04 Mar 2024
Phase 3
13,970
(Bempedoic Acid 180 mg)
sbwubuwrrq = kztpvlkbsv kcsxwbudvm (tcfiieiglf, skeonwpsmf - gxwmxeeise)
-
03 Jan 2024
Matching placebo tablet
(Placebo Comparator)
sbwubuwrrq = hsgbupwemu kcsxwbudvm (tcfiieiglf, xfqmwxtlcx - xgvqdqbine)
Phase 3
-
oohwxeatpq(eahpwesffp) = bqgvvsefln dwjubmpexg (riwjolsalp )
Positive
05 Oct 2023
Not Applicable
-
992
fjstzhzlur(pjtelfwmbr) = ounaerwviv ybshbwnzlc (eyvhqdzdbs, (84.1))
-
26 Aug 2023
fjstzhzlur(pjtelfwmbr) = wctcgzcvot ybshbwnzlc (eyvhqdzdbs, (123.6))
Phase 3
-
4,206
vexwuwpiel(ojmkzechqe): HR = 0.61 (95% CI, 0.39 - 0.98)
Positive
24 Jun 2023
Placebo
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Regulation

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