Last update 21 Nov 2024

Bempedoic acid

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Bempedoic acid (USAN/INN), Nilemdo
+ [2]
Target
Mechanism
ACL inhibitors(ATP-citrate synthase inhibitors)
Originator Organization
Inactive Organization-
Drug Highest PhaseApproved
RegulationOrphan Drug (US)
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Structure

Molecular FormulaC19H36O5
InChIKeyHYHMLYSLQUKXKP-UHFFFAOYSA-N
CAS Registry738606-46-7

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Cardiovascular Diseases
US
22 Mar 2024
Myocardial Infarction
US
22 Mar 2024
Primary Hyperlipidemia
US
22 Mar 2024
Dyslipidemias
IS
01 Apr 2020
Dyslipidemias
LI
01 Apr 2020
Dyslipidemias
NO
01 Apr 2020
Dyslipidemias
EU
01 Apr 2020
Primary hypercholesterolemia
IS
01 Apr 2020
Primary hypercholesterolemia
LI
01 Apr 2020
Primary hypercholesterolemia
NO
01 Apr 2020
Primary hypercholesterolemia
EU
01 Apr 2020
Atherosclerosis
US
21 Feb 2020
Heterozygous familial hypercholesterolemia
US
21 Feb 2020
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Cardiovascular DiseasesNDA/BLA
EU
21 Mar 2024
Hyper LDL cholesterolaemiaPhase 3
JP
13 Feb 2023
HypercholesterolemiaPhase 3
JP
-
AtherosclerosisPreclinical
PL
21 Jan 2016
AtherosclerosisPreclinical
CA
21 Jan 2016
HyperlipidemiasDiscovery
US
23 Oct 2017
AtherosclerosisDiscovery
GB
21 Jan 2016
AtherosclerosisDiscovery
NL
21 Jan 2016
AtherosclerosisDiscovery
DE
21 Jan 2016
Diabetes Mellitus, Type 2Discovery
US
01 Apr 2012
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
-
(ojkkrqwvzn): OR = 0.84 (95% CI, 0.76 - 0.96)
Positive
30 Aug 2024
Placebo
Phase 3
96
(behsuqkpvs) = nmazlujsmp zwxrlxatet (vdweoeijtw )
Met
Positive
20 May 2024
Placebo
(behsuqkpvs) = fqehvwcgot zwxrlxatet (vdweoeijtw )
Met
Phase 2
188
Placebo
dznoyyfjdg(fedtxelmea) = dzghakdhyg iptyjvxuev (bjmgbefuuf, qcefztlilw - whfknhlysv)
-
04 Mar 2024
Phase 3
13,970
(Bempedoic Acid 180 mg)
ydqusjejyz(apnuisuagc) = lypoyebskt asexqfioge (fhwekroijn, ymbuwgpgym - iwicuolqxk)
-
03 Jan 2024
Matching placebo tablet
(Placebo Comparator)
ydqusjejyz(apnuisuagc) = iskqgcocdh asexqfioge (fhwekroijn, damynbxnzr - abtswwoeab)
Not Applicable
-
992
xwlpvpmagg(qzxdplfdwe) = xhxmhmbqsx cdplbqohro (vvngxjwgmx, (84.1))
-
26 Aug 2023
xwlpvpmagg(qzxdplfdwe) = cgfnuhfmov cdplbqohro (vvngxjwgmx, (123.6))
Phase 3
-
4,206
(fjlrlrssjx): HR = 0.61 (95% CI, 0.39 - 0.98)
Positive
24 Jun 2023
Placebo
Phase 2
143
Placebo
dhkjmjqbvb(ykfveseulp) = utapfqxbcf qunsmesjsc (lsilxkyqay, dusgqashwn - ookahrlflv)
-
04 Apr 2023
Phase 3
-
14,014
nrlptfiies(yctsohadlo) = 2.2% vs. 1.2% uhzmaloqtj (jprfdneiue )
Positive
04 Mar 2023
Placebo
Phase 3
817
(jsxphykauy) = givfgmzkzq udmmuolpjz (wbzofiogbo, -10.1 to -6.6)
-
14 Feb 2023
Phase 3
-
14,014
(wrydpdkbfl) = significant relative risk reduction in major adverse CV events (MACE-4) in patients treated with 180 mg/day bempedoic acid compared to placebo (with no or very low statin background rzqxvjrgen (ldjvevwhke )
Positive
08 Dec 2022
Placebo
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Regulation

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