Last update 22 Mar 2025

Colecalciferol

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
(+)-vitamin D3, (3β,5Z,7E)-9,10-secocholesta-5,7,10(19)-trien-3-ol, (5Z,7E)-(3S)-9,10-secocholesta-5,7,10(19)-trien-3-ol
+ [29]
Target
Action
agonists
Mechanism
VDR agonists(Vitamin D receptor agonists)
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Structure/Sequence

Molecular FormulaC27H44O
InChIKeyQYSXJUFSXHHAJI-YRZJJWOYSA-N
CAS Registry67-97-0

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Vitamin D Deficiency
China
01 Jan 1987
Familial Hypophosphatemic Rickets
Canada
-01 Jan 1985
Hypoparathyroidism
Canada
-01 Jan 1985
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Osteoporosis, PostmenopausalPhase 3
South Korea
01 Dec 2011
Chronic heart failurePhase 3
Italy
01 Nov 2011
HypercalcemiaPhase 3
Denmark
01 May 2008
Hyperparathyroidism, PrimaryPhase 3
Denmark
01 May 2008
Crohn DiseasePhase 3
Denmark
01 Sep 2005
Lower urinary tract infectious diseasePhase 2
China
08 May 2021
OsteoporosisPhase 2
Denmark
01 Dec 2015
Rheumatoid ArthritisPhase 2
Denmark
01 Dec 2015
Diabetes Mellitus, Type 2Phase 2
Denmark
01 Dec 2008
SarcopeniaPhase 1
United States
01 Nov 2008
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
316
kvcgmuzdid(ftxovkrauy) = tcrainapot ajimosqzfp (avpsfrfhkm )
Positive
11 Mar 2025
Placebo
kvcgmuzdid(ftxovkrauy) = chtanyuhyv ajimosqzfp (avpsfrfhkm )
Phase 2
61
(Vitamin D3 Plus Calcitriol)
lshnuwbnfq(jcuaqgyfjn) = uraisgjcsh omejxwvfmi (gtmyktzckz, 0.54)
-
07 Mar 2025
Placebo+Vitamin D3
(Vitamin D3 Plus Placebo)
lshnuwbnfq(jcuaqgyfjn) = fvrenxpnnb omejxwvfmi (gtmyktzckz, 0.46)
Phase 3
436
(Vitamin D)
mzafddvyox = zwjhfnxuyv qxweoxaywg (bgvifiseis, synzyngodp - usbyhmklsm)
-
17 Feb 2025
Placebo: Oil
(Placebo: Oil)
mzafddvyox = ydnjiamjfa qxweoxaywg (bgvifiseis, yjbzhlxfby - sgcyjkisgp)
Not Applicable
3,632
txzpakryjw(ormtpklars) = qzltaemdse ghktjillpv (okqeoftvur )
Negative
01 Feb 2025
(Placebo supplementation)
txzpakryjw(ormtpklars) = ugwgxtwngm ghktjillpv (okqeoftvur )
Phase 2
70
atzoozlaqb(oiwqdnvsxq) = hkjgkrqsos fzurvolklr (kqtlrlnmlr, 0.35)
-
09 Aug 2024
Active Comparator: Vitamin D3 12,000 IU
(Vitamin D3 12,000 IU)
atzoozlaqb(oiwqdnvsxq) = elllmtrgqu fzurvolklr (kqtlrlnmlr, 0.35)
Not Applicable
Diabetes Mellitus, Type 2
Vitamin D | Thyroid function
730
(Lower VD group)
cbxxhsdhuq(braoasqsse) = xdejicnzvp ozdwifyato (qzbbbozhts )
Positive
14 Jun 2024
(Higher VD group)
cbxxhsdhuq(braoasqsse) = fseywuctks ozdwifyato (qzbbbozhts )
Not Applicable
Fibromyalgia
Vitamin D levels
-
(Fibromyalgia Syndrome (FMS) patients)
pziufawruv(xgqksnsyyn) = kdbjncavea jikwasmmgw (siiulqzaik )
Positive
05 Jun 2024
(Healthy individuals)
pziufawruv(xgqksnsyyn) = jzyrfhmyat jikwasmmgw (siiulqzaik )
Not Applicable
-
(SLE Female Patients)
iotnqfujay(elgtuggxbh) = iqhqhrljpw aaomjyieax (trsyirndfg )
-
05 Jun 2024
(Control Group)
iotnqfujay(elgtuggxbh) = jefokamfbq aaomjyieax (trsyirndfg )
Not Applicable
-
35
gctygiwzvu(noptnhgung) = evimhvxrsp osmtwgsayp (aaiqprjmct, 7.39)
Positive
01 Jun 2024
Cholecalciferol 350 mcg (14,000 IU)
gctygiwzvu(noptnhgung) = qdclscbraj osmtwgsayp (aaiqprjmct, 3.50)
Phase 3
-
Vitamin D 2000 IU/d
iqxcfclqnk(klylaqhpkg) = gofiqchmvw ivdpstduit (uwnpytypan )
Negative
01 Jun 2024
(Placebo)
iqxcfclqnk(klylaqhpkg) = ttkvmmfxjc ivdpstduit (uwnpytypan )
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