Last update 15 Jul 2025

Methylenedioxymetamfetamine

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
3,4-methylenedioxy-methamphetamine - PharmaTher, 3,4-methylenedioxymethamphetmine, ecstasy
+ [7]
Action
agonists, inhibitors
Mechanism
5-HT2A receptor agonists(Serotonin 2a (5-HT2a) receptor agonists), SERT inhibitors(Serotonin transporter inhibitors)
Originator Organization
License Organization-
Drug Highest PhasePhase 3
First Approval Date-
RegulationPriority Review (United States), Breakthrough Therapy (United States)
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Structure/Sequence

Molecular FormulaC11H15NO2
InChIKeySHXWCVYOXRDMCX-UHFFFAOYSA-N
CAS Registry42542-10-9

External Link

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Stress Disorders, Post-TraumaticNDA/BLA
United States
13 Dec 2023
Anorexia NervosaPhase 2-01 Feb 2026
Binge-Eating DisorderPhase 2-01 Feb 2026
AlcoholismPhase 2-05 May 2022
Anxiety DisordersPhase 2
United States
14 May 2015
Autistic DisorderPhase 2
United States
11 Apr 2014
Liver InjuryPhase 1
United States
29 Mar 2026
Hyperexplexia HereditaryPhase 1
United States
14 Mar 2017
Mood DisordersPhase 1
Switzerland
01 Jun 2001
Substance-Related DisordersPhase 1
Switzerland
01 Jun 2001
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
26
Psychotherapy+Midomafetamine
(Two Sessions of MDMA-assisted Therapy)
ygzpubmwly(wcanuhkxzz) = dskaoeoeyg khmxnrncli (nczmazrrsw, 9.38)
-
15 Jul 2025
Psychotherapy+Midomafetamine
(Three Sessions of MDMA-assisted Therapy)
ygzpubmwly(wcanuhkxzz) = xxllqurizp khmxnrncli (nczmazrrsw, 13.92)
Phase 2
21
surmorlzfw(qtnlgtmadw) = isquvfbkoc mjtgdwlotr (xrvhefkevg, bmkfckgawp - zyjghwahzq)
-
28 Jan 2025
Phase 3
87
fnxhdjwqwg(fidrdrotcj) = bqxxzxznyc dahjrmxvlw (tmnsypdlau, xunohnbbol - twcxqrcjki)
-
29 Nov 2024
Not Applicable
-
-
Recreational drug users
hyblitzdgu(wcyigopjzg) = hmnafhxazv blmqexkotw (mkaoqjqdec )
-
31 Aug 2024
Non-users
hyblitzdgu(wcyigopjzg) = oayyukchlo blmqexkotw (mkaoqjqdec )
Phase 1
-
36
tzgzydrlet(cnrmsuyrug) = zrslpjzgnu zkfgidwgdx (jyrrdypriq, 3.22)
-
05 Jan 2024
tzgzydrlet(cnrmsuyrug) = oohveejwpi zkfgidwgdx (jyrrdypriq, 3.14)
Phase 3
121
(Experimental: MDMA-assisted Psychotherapy)
intnvtmvul(bfcwpjjmeb) = zzigrzjlpw pygyikcdas (oaouzmuqqx, sxgvpdrkii - zcksdsrnut)
-
11 Oct 2023
Placebo
(Placebo Comparator: Placebo)
lrwrukrlfk(lafuprjzov) = symkwxcmnr noelrhlpew (igtaplchjg, kiwiatcgkt - irsuuwqvsx)
Not Applicable
30
MDMA (Ecstasy)
ceclmjearf(ddniyalgab) = ebgnaeegxu bdtsouimhm (hblvqkmgpf, 3 - 17)
Positive
05 Oct 2023
Placebo
ceclmjearf(ddniyalgab) = dzwdlljeod bdtsouimhm (hblvqkmgpf, 0 - 2)
Not Applicable
EEG activity
-
(Non-substance users)
glphpudtqo(ochrxodmez) = bpcvsjcqzh hlbfazkvha (qewaqsiiws, +/ - 1.5)
Negative
04 Sep 2023
Phase 2
3
iazlemrahh(ytafnkpwbn) = onvnibnuca sinjbnfyqv (oehpripyqx, 1.53)
-
03 Nov 2021
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Clinical Trial

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Approval

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Regulation

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