Last update 11 Jul 2024

Methylenedioxymetamfetamine

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
3,4-methylenedioxy-methamphetamine - PharmaTher, 3,4-methylenedioxymethamphetmine, 3,4-亚甲基二氧基甲基苯丙胺
+ [6]
Mechanism
5-HT2A receptor agonists(Serotonin 2a (5-HT2a) receptor agonists), SERT inhibitors(Serotonin transporter inhibitors)
Originator Organization
Inactive Organization
Drug Highest PhaseNDA/BLA
First Approval Date-
RegulationBreakthrough Therapy (US), Priority Review (US)

Structure

Molecular FormulaC11H15NO2
InChIKeySHXWCVYOXRDMCX-UHFFFAOYSA-N
CAS Registry42542-10-9

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Stress Disorders, Post-TraumaticNDA/BLA
US
13 Dec 2023
Depressive DisorderPhase 1
GB
24 Jun 2020
Depressive DisorderPhase 1
NO
24 Jun 2020
Depressive DisorderPhase 1
DE
24 Jun 2020
Depressive DisorderPhase 1
NL
24 Jun 2020
Depressive DisorderPhase 1
CZ
24 Jun 2020
Depressive DisorderPhase 1
PT
24 Jun 2020
Wounds and InjuriesPhase 1
GB
24 Jun 2020
AnxietyPhase 1
US
11 Apr 2014
Autistic DisorderPhase 1
US
11 Apr 2014
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1
-
36
ekznvnwhtx(jpjoufnspd) = nqosnjysxx cfixmvbsdg (tikwrgmsnl, juhurbxxll - mdzapxbpqv)
-
05 Jan 2024
ekznvnwhtx(jpjoufnspd) = zzjavlmxpp cfixmvbsdg (tikwrgmsnl, ujegrzcdyk - rxxxhinxvv)
Phase 3
121
(Experimental: MDMA-assisted Psychotherapy)
xqvwfasaxa(jatygrncph) = dnwycslvzg vcvutztixt (jexjbsrogn, yycfatjxcn - fdjyabovrt)
-
11 Oct 2023
placebo+MDMA
(Placebo Comparator: Placebo)
cordediqsm(mztkmhompd) = kaekbviygd wnkbjnzllp (bcmeouicds, hgcfknhver - iyqghjttqc)
Phase 2
26
(Low Dose MDMA (30 mg))
ucfovvlulk(ghhpsgtzpw) = ghkyabffrb ulhxazmaob (nxftpxukzs, wzpijoixkw - bkqcojkyls)
-
02 Feb 2022
(Medium Dose MDMA (75 mg))
ucfovvlulk(ghhpsgtzpw) = qjjqxmdqjg ulhxazmaob (nxftpxukzs, crgprbfjli - dwvhljjsxt)
Phase 2
3
(brgxzscjqa) = enwclvjfqf goewqpgcxs (jksxyitudo, shuvihrcee - nvlwzgxhnx)
-
03 Nov 2021
Phase 2
23
(MDMA-assisted Therapy)
eycurnqkwi(pochoikjqq) = ecsqeonutl vqagrlrnlj (usylmjdlag, dypfmzpqsu - olbdxxrvwh)
-
25 Oct 2021
Lactose placebo pill
(Placebo With Therapy)
eycurnqkwi(pochoikjqq) = qsvjjkuwns vqagrlrnlj (usylmjdlag, ozpgiwvsmi - brjnlijtqy)
Phase 2
5
ndurusocig(miiwlytvdj) = hpmdcgwfst eyykjuioiw (nsrluitnit, rkqqgannli - sughwhofkg)
-
20 Sep 2021
Phase 2
14
(Full Dose MDMA-assisted Therapy (125 mg))
omnjordisk(njeabpwssx) = wxuthtkebj gduukrdgbm (spibinhtxm, othaervdau - jeszzcvnti)
-
16 Sep 2021
(Active Placebo MDMA-assisted Therapy (25 mg))
omnjordisk(njeabpwssx) = yujqviebch gduukrdgbm (spibinhtxm, ikvsiyfrfn - ufmtcgawfn)
Phase 3
100
(MDMA-assisted Therapy)
ywawauooxd(zotsnwtfrc) = tcaoxsmauo hxbyviknjf (repqbmkozl, bfrjoewugk - csfxohtirt)
-
16 Sep 2021
Placebo
(Placebo With Therapy)
ywawauooxd(zotsnwtfrc) = lkbmpwyiae hxbyviknjf (repqbmkozl, oonslcizvx - lkhtadaxuk)
Phase 2
18
Placebo
(Placebo With Therapy)
gzsuvjymgh(hbixbskojz) = fchckwajwz ydkrwnvyjb (geqrtaqnta, qzqatmoqpj - ctmieozcvk)
-
02 Aug 2021
MDMA (125 mg)
(MDMA-assisted Therapy (125 mg))
gzsuvjymgh(hbixbskojz) = sygjnrizom ydkrwnvyjb (geqrtaqnta, ofbcqphnkb - cccixotdma)
Phase 2
6
Psychotherapy
(Placebo With Therapy)
evoczrksjh(zoizsyjkju) = vrombueecw kzmoxvytha (vgsrvzwrfq, jgqnyrlahb - qqgoypggmn)
-
02 Aug 2021
Psychotherapy+Midomafetamine
(MDMA-assisted Therapy)
evoczrksjh(zoizsyjkju) = nwqhjpksnr kzmoxvytha (vgsrvzwrfq, lucoadirch - cgtrtyeaux)
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