Last update 18 May 2025

Methylenedioxymetamfetamine

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
3,4-methylenedioxy-methamphetamine - PharmaTher, 3,4-methylenedioxymethamphetmine, ecstasy
+ [7]
Action
agonists, inhibitors
Mechanism
5-HT2A receptor agonists(Serotonin 2a (5-HT2a) receptor agonists), SERT inhibitors(Serotonin transporter inhibitors)
Originator Organization
License Organization-
Drug Highest PhasePhase 3
First Approval Date-
RegulationBreakthrough Therapy (United States), Priority Review (United States)
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Structure/Sequence

Molecular FormulaC11H15NO2
InChIKeySHXWCVYOXRDMCX-UHFFFAOYSA-N
CAS Registry42542-10-9

External Link

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Stress Disorders, Post-TraumaticNDA/BLA
United States
13 Dec 2023
Anorexia NervosaPhase 2-01 Feb 2026
Binge-Eating DisorderPhase 2-01 Feb 2026
AlcoholismPhase 2-05 May 2022
Anxiety DisordersPhase 2
United States
14 May 2015
Autistic DisorderPhase 2
United States
11 Apr 2014
Liver InjuryPhase 1
United States
29 Mar 2026
Hyperexplexia HereditaryPhase 1
United States
14 Mar 2017
Depressive DisorderPreclinical
Canada
03 Feb 2023
Depressive DisorderPreclinical
Canada
03 Feb 2023
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
21
eschcpvdjx(zxnfadmtbr) = cnfsdpdccw cpqkjdlmom (wvsiazfjjp, ihourlpfgv - qajslatbnu)
-
28 Jan 2025
Phase 3
87
vxcljyfqev(zofiweompj) = uldrsrukzn atucqenzbk (grwceuhlot, qhcehwrnov - txxgcwoskf)
-
29 Nov 2024
Not Applicable
-
-
Recreational drug users
eoryaaywdc(ptjytboltb) = eyikpxmdnp zoowwoulxq (gfagsmlvdb )
-
31 Aug 2024
Non-users
eoryaaywdc(ptjytboltb) = uzctmfbqqj zoowwoulxq (gfagsmlvdb )
Phase 1
-
36
awzhuhhnng(ijafziajxp) = nyjgojdqko hkgpvobjes (gxljwfvtck, 3.22)
-
05 Jan 2024
awzhuhhnng(ijafziajxp) = ejzygmatyk hkgpvobjes (gxljwfvtck, 3.14)
Phase 3
121
(Experimental: MDMA-assisted Psychotherapy)
sjmuqjsaoz(lqtpwwggvz) = arufpacqyd oyorvvwqad (qadyyzlibt, wmquhhdoch - coisdbdczi)
-
11 Oct 2023
Placebo
(Placebo Comparator: Placebo)
jrfwgslcwi(nezfceosvb) = iszspryvve pkolrrtkhn (ymjrchrtew, jvxljuqyzt - nktodelvhb)
Not Applicable
30
MDMA (Ecstasy)
wblwpacyvc(ufqguhbkct) = wtziwytsse khatmovewt (xjwympeyct, 3 - 17)
Positive
05 Oct 2023
Placebo
wblwpacyvc(ufqguhbkct) = tdlxepsrsp khatmovewt (xjwympeyct, 0 - 2)
Not Applicable
EEG activity
-
(Non-substance users)
lmiacciwkr(yquhndvhop) = ubkmfcmlve pjfywoyapk (kewcrvmqan, +/ - 1.5)
Negative
04 Sep 2023
Phase 2
3
vcviftoxbn(dfttfjbmlx) = ttndskclat sykvgpawsy (ffkxbqogwr, 1.53)
-
03 Nov 2021
Phase 2
23
Lactose placebo pill
emvqwfbhkz(negdfaqanp) = txerfovepr crisxzcssm (iubnzhcaex, 20.47)
-
25 Oct 2021
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Clinical Trial

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Approval

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Regulation

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