Drug Type Small molecule drug |
Synonyms Carisbamate (USAN), Comfyde, JNJ-10234094 + [3] |
Action modulators |
Mechanism Neurotransmitter receptor modulators |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
Active Organization |
Drug Highest PhasePhase 3 |
First Approval Date- |
RegulationOrphan Drug (United States) |
Molecular FormulaC9H10ClNO3 |
InChIKeyOLBWFRRUHYQABZ-MRVPVSSYSA-N |
CAS Registry194085-75-1 |
KEGG | Wiki | ATC | Drug Bank |
---|---|---|---|
D06573 | Carisbamate |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Epilepsy | NDA/BLA | United States | - | |
Epilepsy | NDA/BLA | European Union | - | |
Langer-Giedion Syndrome | Phase 3 | United States | 28 Apr 2022 | |
Langer-Giedion Syndrome | Phase 3 | Argentina | 28 Apr 2022 | |
Langer-Giedion Syndrome | Phase 3 | Australia | 28 Apr 2022 | |
Langer-Giedion Syndrome | Phase 3 | Colombia | 28 Apr 2022 | |
Langer-Giedion Syndrome | Phase 3 | Germany | 28 Apr 2022 | |
Langer-Giedion Syndrome | Phase 3 | Greece | 28 Apr 2022 | |
Langer-Giedion Syndrome | Phase 3 | Hungary | 28 Apr 2022 | |
Langer-Giedion Syndrome | Phase 3 | Israel | 28 Apr 2022 |
Phase 1/2 | 11 | Placebo (Placebo) | ptzwstonqu(cqbkzzrwoh) = tiqmlzjhdz eyicaqesoq (adqtxaieft, 7.1) View more | - | 02 Mar 2021 | ||
(Carisbamate) | ptzwstonqu(cqbkzzrwoh) = yrlqzetwyt eyicaqesoq (adqtxaieft, 7.6) View more | ||||||
Phase 3 | 547 | kkxslkvsta(tgprdtahnf) = Dizziness was the most common treatment-emergent adverse event, with a higher incidence (≥ 5% difference) in the combined carisbamate group (31%) than placebo (9%); the incidence was higher with carisbamate 1,200 mg (32%, n = 58) than with carisbamate 800 mg (30%, n = 53) mviarlyggn (mdhhwbtdll ) | Negative | 01 Apr 2011 | |||
Not Applicable | 419 | utkvlnnnrm(kasmqlmpza) = low behavioral/psychiatric adverse event rates tvtnakojff (tdvwrrowqm ) View more | Positive | 02 Jul 2009 | |||
Not Applicable | - | qlckalngfs(zpfliszxdi) = low behavioral/psychiatric adverse event rates mmmuuxvaxv (sxirxgstws ) View more | Positive | 02 Jul 2009 |