Drug Type Small molecule drug |
Synonyms Nimustine, Nimustine hydrochloride (JAN), 尼莫司汀 + [6] |
Target |
Action inhibitors |
Mechanism DNA inhibitors(DNA inhibitors) |
Therapeutic Areas |
Inactive Indication- |
Originator Organization |
Active Organization |
Inactive Organization- |
Drug Highest PhaseApproved |
First Approval Date Japan (22 May 1979), |
Regulation- |
Molecular FormulaC9H13ClN6O2 |
InChIKeyVFEDRRNHLBGPNN-UHFFFAOYSA-N |
CAS Registry42471-28-3 |
KEGG | Wiki | ATC | Drug Bank |
---|---|---|---|
D01059 | Nimustine Hydrochloride |
Indication | Country/Location | Organization | Date |
---|---|---|---|
Chronic Lymphocytic Leukemia | China | 25 Jul 2002 | |
Philadelphia chromosome positive chronic myelogenous leukemia | China | 25 Jul 2002 | |
Brain Cancer | Japan | 22 May 1979 | |
Chronic leukemia | Japan | 22 May 1979 | |
Colorectal Cancer | Japan | 22 May 1979 | |
Liver Cancer | Japan | 22 May 1979 | |
Lung Cancer | Japan | 22 May 1979 | |
Lymphoma | Japan | 22 May 1979 | |
Stomach Cancer | Japan | 22 May 1979 |
Phase 2 | 21 | (tfmxcfeupf) = rfhuinezfc lezkkxtfyg (senrfikqqt ) View more | Positive | 02 Jun 2022 | |||
Phase 1/2 | 49 | jtyjkmglos(bayqyegyaj) = Thirty-five percent of patients experienced grade 3 or 4 toxicities, mainly hematologic bavivwtxdj (nohmmrsphn ) | Positive | 05 Nov 2018 | |||
Phase 1/2 | 49 | ymnlfzruan(oqwvomgwnz) = Thirty-five percent of patients experienced grade 3 or 4 toxicities, mainly hematologic dzetmaqlsw (kzuxbwyvoz ) View more | Positive | 06 Nov 2017 | |||
Phase 1/2 | 49 | iinexgxgms(sswvxtyjav) = Thirty-five percent of patients (14 of 40) experienced grade 3 or 4 toxicities, mainly hematologic ikgqaqmfev (utvnduoncv ) | Positive | 07 Nov 2016 | |||
Not Applicable | 359 | wwubocmfam(vwezrcaaij) = zsfaygijwx xgzgvtliqg (kxjxnyajau ) | - | 20 May 2010 | |||
crympmclsv(vllucaosuy) = vvvivwxyei envheywdur (jinavjvewn ) | |||||||
Not Applicable | Recurrent Glioblastoma Third line | 35 | omvgjslmgf(mkyvauwkyc) = ctjcttedvn rgaplwopuq (htzjgoverk ) View more | Positive | 20 May 2008 | ||
Not Applicable | 151 | (prqgushaze) = hcenesuols hgbkrxrvuq (ptbqnqzpfe ) | Positive | 20 May 2008 |