Last update 29 Sep 2024

Atrasentan

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Atrasentan hydrochloride, Xinlay, (+)-A 127722
+ [12]
Target
Mechanism
ETA antagonists(Endothelin receptor type A antagonists)
Originator Organization
Inactive Organization
Drug Highest PhaseNDA/BLA
First Approval Date-
RegulationOrphan Drug (US), Orphan Drug (EU), Special Review Project (US)

Structure

Molecular FormulaC29H38N2O6
InChIKeyMOTJMGVDPWRKOC-QPVYNBJUSA-N
CAS Registry173937-91-2

External Link

KEGGWikiATCDrug Bank
-Atrasentan-

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Glomerulonephritis, IGANDA/BLA
US
18 Jul 2024
Chronic Kidney DiseasesPhase 3
US
11 Dec 2020
Chronic Kidney DiseasesPhase 3
CN
11 Dec 2020
Chronic Kidney DiseasesPhase 3
JP
11 Dec 2020
Chronic Kidney DiseasesPhase 3
AR
11 Dec 2020
Chronic Kidney DiseasesPhase 3
AU
11 Dec 2020
Chronic Kidney DiseasesPhase 3
BR
11 Dec 2020
Chronic Kidney DiseasesPhase 3
CA
11 Dec 2020
Chronic Kidney DiseasesPhase 3
CO
11 Dec 2020
Chronic Kidney DiseasesPhase 3
FR
11 Dec 2020
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
Diabetes Mellitus, Type 2 | Chronic Kidney Diseases
estimated glomerular filtration rate | urinary albumin-to-creatinine ratio
1,834
ndkrfviuca(ciufstnaur) = xlpbfkdric xkvvzetijz (kztefxotbp, 0.72 - 0.93)
Positive
01 Dec 2023
Placebo
ndkrfviuca(ciufstnaur) = flgxfqowwy xkvvzetijz (kztefxotbp )
Phase 3
-
llmqxzsulv(usddmjzffb) = The study met its primary efficacy endpoint at the 36-week interim analysis, with atrasentan demonstrating superiority versus placebo with a clinically meaningful and highly statistically significant reduction in proteinuria (protein in urine) in patients with IgAN receiving supportive care (maximally tolerated and stable dose of a renin-angiotensin system [RAS] inhibitor). tkuaiejuvd (sxmbemvetv )
Met
Positive
30 Oct 2023
Placebo
Phase 2
-
Atrasentan 0.75mg/d
qnvrcryjxx(nnjcbcdnub) = ahzpoacins ytjyeurqnf (rhgpsybnwz, -52.7 to 1.0)
Positive
05 Nov 2022
Phase 2
-
ibzxwkbxxh(xotywhnlzs) = cpcdbdjrvz xvjhoogwpu (lrcbqrfogw, 39.8 - 58.3)
Positive
03 Nov 2022
Phase 2
20
syunxmremf(osdajrfkjh) = tpkjxauywt futdydcgvk (nrlddvrkto )
Positive
01 Nov 2022
Phase 3
5,107
eojkpdauqa(pxizyqrlia): HR = 1.39 (95% CI, 0.97 - 1.99), P-Value = 0.072
Positive
01 Jul 2022
Placebo
Phase 2
17
gisglrphkx(jreihrinqd) = fkdgmtlqsw mebcehkprq (sjouqflppl, 29.0 - 55.2)
Positive
03 May 2022
Phase 3
3,668
(rvqxvcmhen): hazard ratio = 1.39 (95% CI, 0.97 - 1.99)
-
01 Dec 2021
Placebo
Not Applicable
Heart Failure
eGFR | UACR
3,668
jalownfkej(dmpdidrrss): HR = 1.39 (95% CI, 0.97 - 1.99)
Positive
27 Oct 2021
Placebo
Not Applicable
-
(IgA-containing immune complexes)
qqaldvexzh(hhaqikwetd) = nfzkgkqpcl dftmlsijiw (hbgoasozbs, 0.13)
-
01 Apr 2021
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