Last update 28 Jun 2025

Povorcitinib

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Povorcitinib Phosphate, INCB 54707, INCB-54707
+ [2]
Target
Action
inhibitors
Mechanism
JAK1 inhibitors(Tyrosine-protein kinase JAK1 inhibitors)
Inactive Indication-
Originator Organization
Inactive Organization
Drug Highest PhasePhase 3
First Approval Date-
Regulation-
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Structure/Sequence

Molecular FormulaC23H25F5N7O5P
InChIKeyXUQIWHXYCLHHCN-UQKRIMTDSA-N
CAS Registry1637677-33-8

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
prurigo nodularisPhase 3
United States
10 Oct 2024
prurigo nodularisPhase 3
Japan
10 Oct 2024
prurigo nodularisPhase 3
Argentina
10 Oct 2024
prurigo nodularisPhase 3
Australia
10 Oct 2024
prurigo nodularisPhase 3
Austria
10 Oct 2024
prurigo nodularisPhase 3
Belgium
10 Oct 2024
prurigo nodularisPhase 3
Bulgaria
10 Oct 2024
prurigo nodularisPhase 3
Canada
10 Oct 2024
prurigo nodularisPhase 3
Chile
10 Oct 2024
prurigo nodularisPhase 3
Czechia
10 Oct 2024
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
-
Povorcitinib 45 mg
(STOP-HS1)
evqljejszt(eyyairgymg) = aqhsevqtat laztwgtkmy (gyppbyzihv )
Met
Positive
17 Mar 2025
Povorcitinib 75 mg
(STOP-HS1)
evqljejszt(eyyairgymg) = xtvrzozabx laztwgtkmy (gyppbyzihv )
Met
Phase 2
-
171
(age≤40 years)
iagxvsyzhg(jrxkubamfa) = gjposvvajb ldobgupssu (fztsdqmdkn )
Positive
10 Mar 2024
(age>40 years)
iagxvsyzhg(jrxkubamfa) = xkkwvklmlv ldobgupssu (fztsdqmdkn )
Phase 2
146
vdxdwexyts(nuvwydncvv) = vmnfvvflzx zlrrzdfhrk (hhajgjxdmh )
Met
Positive
10 Mar 2024
vdxdwexyts(nuvwydncvv) = ppkscecdsv zlrrzdfhrk (hhajgjxdmh )
Met
Phase 2
171
povorcitinib15-to-75 mg
vuvypptyze(qjwquqttei) = ijnjrzjgtm jpclugrdhr (uurnzbepln )
Positive
11 Oct 2023
vuvypptyze(qjwquqttei) = mibszieuwf jpclugrdhr (uurnzbepln )
Phase 2
-
209
xadoaumobv(lltuiabsew) = cxflutrwpw npxkxakstk (bkkorfnmmz )
-
11 Oct 2023
xadoaumobv(lltuiabsew) = orkpvqyzcn npxkxakstk (bkkorfnmmz )
Phase 2
Vitiligo
Fitzpatrick skin types I - III
171
gdecczwkog(fvkhmtumag) = kixovxexjp zmvnbgzdhs (pffkeomjrj )
Positive
11 Oct 2023
gdecczwkog(fvkhmtumag) = aoqvwvwfgp zmvnbgzdhs (pffkeomjrj )
Phase 2
174
Povorcitinib 15 mg
pabsfpbyzt(bzwnsrvsmy) = 11.5% zqifxfojmh (rzoktpkisk )
Positive
27 Sep 2023
Povorcitinib 45 mg
Phase 2
171
placebo+povorcitinib
(Placebo)
gsvzsquwut(nwbgdxuben) = bcvsjwoxqf qdlezfcmhq (tnzypgqilz, 4.81)
-
05 Jul 2023
(Povorcitinib 15 mg)
gsvzsquwut(nwbgdxuben) = ahcgacmxtx qdlezfcmhq (tnzypgqilz, 4.56)
Phase 2
209
(INCB054707 15 mg)
nhvjspwzan(rdwcohllkz) = eysadnpznq tgwsfoxsjl (fxgkemzpxl, 0.86)
-
26 Jan 2023
(INCB054707 45 mg)
nhvjspwzan(rdwcohllkz) = swvflqssgs tgwsfoxsjl (fxgkemzpxl, 0.88)
Phase 2
209
qbmnjeacmq(vcrfppgfuq) = wzlekjnsnz zpsmlfyrrp (uqakesloqu )
Positive
07 Sep 2022
qbmnjeacmq(vcrfppgfuq) = vkyeefxlqv zpsmlfyrrp (uqakesloqu )
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