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Last update 30 Aug 2025
Antisense PTP-1B gene therapy(Ionis Pharmaceuticals, Inc.)
Last update 30 Aug 2025
Overview
Basic Info
Drug Type ASO |
Synonyms IONIS PTP1BRX, IONIS-PTP1BRX, ISIS-PTP1BRX + [1] |
Target |
Action inhibitors |
Mechanism PTP1B inhibitors(Protein-tyrosine phosphatase 1B inhibitors) |
Therapeutic Areas |
Active Indication- |
Inactive Indication |
Originator Organization |
Active Organization- |
Inactive Organization |
License Organization- |
Drug Highest PhasePendingPhase 2 |
First Approval Date- |
Regulation- |
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Structure/Sequence
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Related
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Clinical Trials associated with Antisense PTP-1B gene therapy(Ionis Pharmaceuticals, Inc.)NCT01918865
A Double Blind, Placebo-Controlled, Phase 2 Study to Assess the Safety, Tolerability, and Efficacy of ISIS 404173 Administered Once Weekly to Obese Patients With Type 2 Diabetes Mellitus Being Treated With Metformin or Metformin Plus Sulfonylurea
100 Clinical Results associated with Antisense PTP-1B gene therapy(Ionis Pharmaceuticals, Inc.)
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100 Translational Medicine associated with Antisense PTP-1B gene therapy(Ionis Pharmaceuticals, Inc.)
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100 Patents (Medical) associated with Antisense PTP-1B gene therapy(Ionis Pharmaceuticals, Inc.)
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100 Deals associated with Antisense PTP-1B gene therapy(Ionis Pharmaceuticals, Inc.)
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R&D Status
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| Indication | Highest Phase | Country/Location | Organization | Date |
|---|---|---|---|---|
| Diabetes Mellitus, Type 2 | Phase 2 | Argentina | 01 Aug 2013 | |
| Diabetes Mellitus, Type 2 | Phase 2 | Canada | 01 Aug 2013 | |
| Diabetes Mellitus, Type 2 | Phase 2 | South Africa | 01 Aug 2013 | |
| Obesity | Phase 2 | Argentina | 01 Aug 2013 | |
| Obesity | Phase 2 | Canada | 01 Aug 2013 | |
| Obesity | Phase 2 | South Africa | 01 Aug 2013 |
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Clinical Result
Clinical Result
Indication
Phase
Evaluation
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NCT01918865 (Pubmed) Manual  | Phase 2 | 92 | wayxxyrflt(nhbvjisylz) = aoolzgfnwe hdpnjcsfhf (dsqcqpobqd ) View more | Positive | 01 Apr 2018 | ||
Placebo | - | ||||||
Phase 2 | - | zuleuorpdu(eygikbmfuw) = carvjhyprq uzcfojzvkq (mtuudrwahy ) View more | Positive | 15 Sep 2015 |
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Translational Medicine
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Deal
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Core Patent
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Clinical Trial
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Approval
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Regulation
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