Ictal SPECT with intravenous injection in a cubital vein of a perfusion tracer is an established technique to localize the ictal onset zone during presurgical evaluation of refractory focal epilepsy. When seizures last less than 10 seconds, localizing information is often not obtained. Since it takes around 30 seconds before the tracer reaches the brain after intravenous injection, ictal hyperperfusion most likely has already switched to postictal hypoperfusion. In this study, we plan to inject the perfusion tracer in the aorta proximal to the cerebral arteries, which will allow a true ictal injection in patients with seizures of short duration.

Start Date01 May 2016

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100 Clinical Results associated with Technetium Tc-99M Bicisate Kit

100 Translational Medicine associated with Technetium Tc-99M Bicisate Kit

100 Patents (Medical) associated with Technetium Tc-99M Bicisate Kit

Literatures (Medical) associated with Technetium Tc-99M Bicisate Kit

01 Jun 2024·Radiological Physics and Technology

Feasibility study of radioactivity estimation of 99mTc and 123I-labeled radiopharmaceuticals using shielded syringes

Article

Author: Yasuno, Narumi ; Nakamura, Yuto

This study investigates the feasibility of estimating the radioactivity of radiopharmaceuticals using shielded syringes. The radioactivities of ^99mTc-MDP, ^99mTc-HMDP, ^99mTc-ECD, ^99mTc-MAG₃, and ¹²³I-IMP were measured using a dose calibrator. Correlation coefficients and regression equations were obtained from the radioactivity in the shielded and unshielded syringes. ^99mTc-MDP was also measured for residual radioactivity after the administration. The correlation coefficients of ^99mTc-MDP, ^99mTc-HMDP, ^99mTc-ECD, ^99mTc-MAG₃, and ¹²³I-IMP were r_s = 0.9998, r_s = 0.9997, r_s = 0.9999, r_s = 0.9998, and r_s = 0.9888, respectively. The regression equations were y = 0.0364x + 0.0913, y = 0.0349x + 0.0273, y = 0.0343x - 0.0018, y = 0.0522x + 0.1215, and y = 0.0383x + 0.0058, respectively. The correlation coefficient for the residual radioactivity of ^99mTc-MDP was r_s = 0.9887 and the regression equation was y = 0.1505x + 0.0853. The radioactivity of ^99mTc- and ¹²³I-labeled radiopharmaceuticals in shielded syringes was accurately measured. It was suggested that the measuring shielded syringes could provide an estimate of the actual radioactivity.

01 Nov 2021·Clinical Nuclear MedicineQ3 · MEDICINE

No Evidence to Favor 99mTc-HMPAO or 99mTc-ECD for Ictal Brain Perfusion SPECT for Identification of the Seizure Onset Zone

Q3 · MEDICINE

Article

Author: Stodieck, Stefan ; Jaber, Mariam ; Apostolova, Ivayla ; Lanz, Michael ; Sauvigny, Thomas ; Voges, Berthold ; Lindenau, Matthias ; Martens, Tobias ; Klutmann, Susanne ; House, Patrick M ; Buchert, Ralph ; Taherpour, Jila

PurposeIctal brain perfusion SPECT with the tracer 99mTc-HMPAO or 99mTc-ECD is widely used for identification of the epileptic seizure onset zone (SOZ) in presurgical evaluation if standard pointers are uncertain or inconsistent. For both tracers, there are theoretical arguments to favor it over the other for this task. The aim of this study was to compare the performance of ictal brain perfusion SPECT between 99mTc-HMPAO and 99mTc-ECD in a rather large patient sample.Patients and MethodsThe study retrospectively included 196 patients from clinical routine in whom ictal perfusion SPECT had been performed with stabilized 99mTc-HMPAO (n = 110) or 99mTc-ECD (n = 86). Lateralization and localization of the SOZ were obtained by the consensus of 2 independent readers based on visual inspection of the SPECT images.ResultsThe 99mTc-HMPAO group and the 99mTc-ECD group were well matched with respect to age, sex, age at first seizure, duration of disease, seizure frequency, history of previous brain surgery, and findings of presurgical MRI. The proportion of lateralizing ictal SPECT did not differ significantly between 99mTc-HMPAO and 99mTc-ECD (65.5% vs 72.1%, P = 0.36). Sensitivity of ictal perfusion SPECT (independent of the tracer) for correct localization of the SOZ in 62 patients with temporal lobe epilepsy and at least worthwhile improvement (Engel scale ≤ III) 12 months after temporal epilepsy surgery was 63%.ConclusionsThis study does not provide evidence to favor 99mTc-HMPAO or 99mTc-ECD for identification of the SOZ by ictal perfusion SPECT.

01 Nov 2020·Journal of NeuroimagingQ3 · MEDICINE

The Role of the Cerebellum in Pain Perception: A Brain SPECT Perfusion Study in Patients with Burn Injuries

Q3 · MEDICINE

Article

Author: Lewis, David H. ; Sharar, Sam ; Hoffman, Hunter ; Patterson, David ; Minoshima, Satoshi ; Zacharias, Claudia ; Bermo, Mohammed S. ; Wilson, Ann

ABSTRACTBACKGROUND AND PURPOSEVirtual reality (VR) is a promising tool for distraction analgesia. This study aims to compare brain perfusion patterns while patients were undergoing burn wound care in two conditions—VR distraction and control (NoVR).METHODSWith IRB approval, four patients hospitalized for acute burn care (three males and one female) participated in the study. All patients underwent wound care on two consecutive days; 1 day with standard analgesia and adjunctive VR, and the other day with standard analgesia alone, otherwise the wound care was very similar. Tc‐99m ethyl cysteinate dimer was injected during wound care at the time of peak pain. Subjective patient reports on a 0‐10 scale of pain intensity, time spent thinking about pain, and “fun” as well as opioid equivalent usage were analyzed. Voxel by voxel subtraction analysis of brain perfusion Single Photon Emission Computed Tomography (SPECT) images was performed at the group level. Statistical significance threshold was defined as P < .05.RESULTSMean group subjective scores (VR, NoVR, statistical significance, and P‐value) were observed for maximal pain intensity (9.0, 8.8, insignificant, and P = .809), time spent thinking about pain (5.2, 10.0, significant, and P = .015), and fun (6.0, 2.5, significant, and P = .012). Subtraction group analysis demonstrated VR‐induced modulation of brain activity with statistically significant relative suppression of cerebellar activation in the VR compared to intense cerebellar activation in the NoVR environments.CONCLUSIONRelative decrease in cerebellar perfusion based on stringent statistical threshold in the VR environment combined with improved subjective pain experience supports the hypotheses on the role of cerebellum in perception of noxious stimuli.

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Indication	Country/Location	Organization	Date
Central nervous system injury	US	Lantheus Medical Imaging, Inc.	23 Nov 1994
Brain Diseases	JP	PDRadiopharma, Inc.	19 Jan 1994

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


SNMMI2018	Not Applicable	Moya-Moya Disease	-	99m Tc-Ethyl cysteinate dimer (Pre-surgery)	lzewkudqel(tbihermpgj) = hgehyoxtih plszcnwlpq (gjttaviriy, 3.7) View more	-	23 May 2018
				99m Tc-Ethyl cysteinate dimer (Post-surgery)	lzewkudqel(tbihermpgj) = klqisjcjtl plszcnwlpq (gjttaviriy, 4.6) View more

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