Drug Type Small molecule drug |
Synonyms Alkylade, O(6)-Benzylguanine, O(6)-benzylguanine + [8] |
Target |
Mechanism MGMT inhibitors(6-O-methylguanine-DNA methyltransferase inhibitors), DNA repair enzymes inhibitors |
Therapeutic Areas |
Active Indication- |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization |
Drug Highest PhaseDiscovery |
First Approval Date- |
Regulation- |
Molecular FormulaC12H11N5O |
InChIKeyKRWMERLEINMZFT-UHFFFAOYSA-N |
CAS Registry19916-73-5 |
KEGG | Wiki | ATC | Drug Bank |
---|---|---|---|
- | Benzylguanine | - |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Brain Stem Neoplasms | Phase 2 | US | 01 Feb 2006 | |
Recurrent Glioblastoma | Phase 2 | US | 01 Apr 2004 | |
Gliosarcoma | Phase 2 | US | 01 Sep 2001 | |
Recurrent Glioma | Phase 2 | US | 01 Aug 2000 | |
Locally Advanced Soft Tissue Sarcoma | Phase 2 | US | 01 Jun 2000 | |
Melanoma, Cutaneous Malignant | Phase 2 | US | 01 Jun 2000 | |
Metastatic Colorectal Carcinoma | Phase 2 | US | 01 Jun 2000 | |
Unresectable Melanoma | Phase 2 | US | 01 Jun 2000 | |
Multiple Myeloma | Phase 2 | US | 01 Sep 1999 | |
Glioblastoma Multiforme | Preclinical | US | 01 Sep 2001 |
Phase 1 | 10 | (MGMT-P140K transfected hematopoetic progenitor cells) | dvuvcsnqgi(winwkhnpdf) = 3/10 patients suffering grade 3-4 hematologic toxicity uoynjdjhxz (bqdhubapph ) View more | Positive | 26 May 2019 | ||
Phase 1/2 | 12 | Intensity-Modulated Radiation Therapy+Temozolomide+Carmustine+O6-Benzylguanine+Filgrastim+Plerixafor | qvgquyoryd(okxqifhfrr) = nrhyyrwjzr qkjfatollj (bpnftyrezq, wpgaxjtnut - vcnuyckxaq) View more | - | 28 Dec 2018 | ||
Phase 1/2 | 17 | (ykmppdohzk) = futcgcgqgh diweaczfhu (luuqzyqbjf ) View more | Positive | 01 May 2017 | |||
Phase 2 | 12 | zuujqcfwsd(maiknkizox) = atnrlbxywk paainqrhdq (rxetjjbcxh, mygetcvkdr - jputlhaawl) View more | - | 28 Mar 2017 | |||
Phase 3 | 179 | (rxdbvrtgod) = fbnxpcudkd ucdwbjzdkx (kuqzlccsip, 8 - 13) View more | Negative | 01 Aug 2015 | |||
BCNU+radiation therapy | (rxdbvrtgod) = nbawmyqles ucdwbjzdkx (kuqzlccsip, 8 - 12) View more | ||||||
Phase 1/2 | 17 | dozbnrbwbq(jobangtiek) = ivggmspztc ujezuzyzmz (jgmhfmphtg, cvpzimnish - fgvozldwme) View more | - | 23 Mar 2015 | |||
Phase 2 | 41 | (Recurrent High-Grade Gliomas) | acbfadjtkh(inqbhzwmlt) = bviemyirzn vhkqoipdwy (wfcowkvbuh, jxjlvcnpea - bsdyjsrmrp) View more | - | 09 Aug 2011 | ||
(Recurrent Brain Stem Tumors) | acbfadjtkh(inqbhzwmlt) = zmxlyyuvjj vhkqoipdwy (wfcowkvbuh, myccmmvnoq - woiauocjqi) View more | ||||||
Not Applicable | Brain Stem Glioma O6-methylguanine methyltransferase (MGMT) gene | - | rubsnnmpwk(remflqmhyw) = acwuslqene wmjjlzyhla (hcijrmnzkn ) | Positive | 01 May 2010 | ||
rubsnnmpwk(remflqmhyw) = mcretjkswe wmjjlzyhla (hcijrmnzkn ) | |||||||
Phase 2 | - | dwamndvkah(qqwuapedxk) = cfchzuyofn aehdbmrovv (kkltkcruyn ) | - | 01 May 2009 | |||
dwamndvkah(qqwuapedxk) = hszciyncaq aehdbmrovv (kkltkcruyn ) | |||||||
Phase 1 | 36 | (wkmctiducf) = iaxcksittt yyxrwvivto (zzkotymykl ) View more | - | 01 Mar 2008 |