Last update 01 Nov 2024

Benzylguanine

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Alkylade, O(6)-Benzylguanine, O(6)-benzylguanine
+ [8]
Target
Mechanism
MGMT inhibitors(6-O-methylguanine-DNA methyltransferase inhibitors), DNA repair enzymes inhibitors
Active Indication-
Active Organization
Drug Highest PhaseDiscovery
First Approval Date-
Regulation-
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Structure

Molecular FormulaC12H11N5O
InChIKeyKRWMERLEINMZFT-UHFFFAOYSA-N
CAS Registry19916-73-5

External Link

KEGGWikiATCDrug Bank
-Benzylguanine-

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Brain Stem NeoplasmsPhase 2
US
01 Feb 2006
Recurrent GlioblastomaPhase 2
US
01 Apr 2004
GliosarcomaPhase 2
US
01 Sep 2001
Recurrent GliomaPhase 2
US
01 Aug 2000
Locally Advanced Soft Tissue SarcomaPhase 2
US
01 Jun 2000
Melanoma, Cutaneous MalignantPhase 2
US
01 Jun 2000
Metastatic Colorectal CarcinomaPhase 2
US
01 Jun 2000
Unresectable MelanomaPhase 2
US
01 Jun 2000
Multiple MyelomaPhase 2
US
01 Sep 1999
Glioblastoma MultiformePreclinical
US
01 Sep 2001
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1
10
(MGMT-P140K transfected hematopoetic progenitor cells)
dvuvcsnqgi(winwkhnpdf) = 3/10 patients suffering grade 3-4 hematologic toxicity uoynjdjhxz (bqdhubapph )
Positive
26 May 2019
Phase 1/2
12
Intensity-Modulated Radiation Therapy+Temozolomide+Carmustine+O6-Benzylguanine+Filgrastim+Plerixafor
qvgquyoryd(okxqifhfrr) = nrhyyrwjzr qkjfatollj (bpnftyrezq, wpgaxjtnut - vcnuyckxaq)
-
28 Dec 2018
Phase 1/2
17
(ykmppdohzk) = futcgcgqgh diweaczfhu (luuqzyqbjf )
Positive
01 May 2017
Phase 2
12
zuujqcfwsd(maiknkizox) = atnrlbxywk paainqrhdq (rxetjjbcxh, mygetcvkdr - jputlhaawl)
-
28 Mar 2017
Phase 3
179
BCNU+radiation therapy+O?-benzylguanine
(rxdbvrtgod) = fbnxpcudkd ucdwbjzdkx (kuqzlccsip, 8 - 13)
Negative
01 Aug 2015
BCNU+radiation therapy
(rxdbvrtgod) = nbawmyqles ucdwbjzdkx (kuqzlccsip, 8 - 12)
Phase 1/2
17
Laboratory Biomarker Analysis+Carmustine+O6-benzylguanine
dozbnrbwbq(jobangtiek) = ivggmspztc ujezuzyzmz (jgmhfmphtg, cvpzimnish - fgvozldwme)
-
23 Mar 2015
Phase 2
41
(Recurrent High-Grade Gliomas)
acbfadjtkh(inqbhzwmlt) = bviemyirzn vhkqoipdwy (wfcowkvbuh, jxjlvcnpea - bsdyjsrmrp)
-
09 Aug 2011
(Recurrent Brain Stem Tumors)
acbfadjtkh(inqbhzwmlt) = zmxlyyuvjj vhkqoipdwy (wfcowkvbuh, myccmmvnoq - woiauocjqi)
Not Applicable
Brain Stem Glioma
O6-methylguanine methyltransferase (MGMT) gene
-
rubsnnmpwk(remflqmhyw) = acwuslqene wmjjlzyhla (hcijrmnzkn )
Positive
01 May 2010
rubsnnmpwk(remflqmhyw) = mcretjkswe wmjjlzyhla (hcijrmnzkn )
Phase 2
-
dwamndvkah(qqwuapedxk) = cfchzuyofn aehdbmrovv (kkltkcruyn )
-
01 May 2009
dwamndvkah(qqwuapedxk) = hszciyncaq aehdbmrovv (kkltkcruyn )
Phase 1
36
(wkmctiducf) = iaxcksittt yyxrwvivto (zzkotymykl )
-
01 Mar 2008
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Approval

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Regulation

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