Last update 05 Dec 2024

Benzylguanine

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Alkylade, O(6)-Benzylguanine, O(6)-benzylguanine
+ [8]
Target
Mechanism
MGMT inhibitors(6-O-methylguanine-DNA methyltransferase inhibitors), DNA repair enzymes inhibitors
Active Indication-
Active Organization
Drug Highest PhaseDiscovery
First Approval Date-
Regulation-
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Structure

Molecular FormulaC12H11N5O
InChIKeyKRWMERLEINMZFT-UHFFFAOYSA-N
CAS Registry19916-73-5

External Link

KEGGWikiATCDrug Bank
-Benzylguanine-

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Glioblastoma MultiformePhase 3
US
01 Sep 2001
GliosarcomaPhase 3
US
01 Sep 2001
Cutaneous T-cell lymphoma refractoryPhase 2
US
01 Feb 2010
Sezary SyndromePhase 2
US
01 Feb 2010
Mixed oligoastrocytomaPhase 2
US
01 Oct 2006
OligodendrogliomaPhase 2
US
01 Oct 2006
Brain Stem NeoplasmsPhase 2
US
01 Feb 2006
Recurrent Malignant GliomaPhase 2
US
01 Feb 2006
Recurrent GlioblastomaPhase 2
US
01 Apr 2004
Recurrent GliomaPhase 2
US
01 Aug 2000
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1
10
(MGMT-P140K transfected hematopoetic progenitor cells)
nxhttnsmku(sbqzvkjyun) = 3/10 patients suffering grade 3-4 hematologic toxicity wvhooqbjoi (kqfoauzjfm )
Positive
26 May 2019
Phase 1/2
12
Intensity-Modulated Radiation Therapy+Temozolomide+Carmustine+O6-Benzylguanine+Filgrastim+Plerixafor
ourvossffq(ulyhwkujrw) = erccrrerhw khhselazrm (lqeyvxksbz, ykqcaifmjb - apwbdsstps)
-
28 Dec 2018
Phase 1/2
17
fonmdjxyxb(qpkxmieioi) = svdipqjvcc azxfyksicf (vxfwtcwtvi )
Positive
01 May 2017
Phase 2
12
wlhdhvxfnq(vexwcayqnm) = vrnjkomywp gjzvscmgpr (yiezslnzri, oxhpbwfzst - fsvneyxtuf)
-
28 Mar 2017
Phase 3
179
BCNU+radiation therapy+O?-benzylguanine
aljspjpnay(optlusebco) = igzwbttpyy hmyjztbyli (bjtaesgfbd, 8 - 13)
Negative
01 Aug 2015
BCNU+radiation therapy
aljspjpnay(optlusebco) = vrrbcfqcps hmyjztbyli (bjtaesgfbd, 8 - 12)
Phase 1/2
17
Laboratory Biomarker Analysis+Carmustine+O6-benzylguanine
klqlwzjafc(dueaixegar) = mviafbkkma nzhddylrqr (tkceawsqpc, amepxzeclp - ljvgcfqksr)
-
23 Mar 2015
Not Applicable
-
jdprshjnop(xcswzyrqzp) = amzxrfuqzd xfflgumkvx (dgoeehvgab )
-
01 Oct 2014
Phase 2
41
(Recurrent High-Grade Gliomas)
mqxmhxywbt(ekuxdmqrik) = avmnwvhhdp tujersbfbv (ieggimcevl, htbnnbwivm - iwsgpncjvm)
-
09 Aug 2011
(Recurrent Brain Stem Tumors)
mqxmhxywbt(ekuxdmqrik) = enmaeordqo tujersbfbv (ieggimcevl, ugwekqtlvi - uufaadgixa)
Phase 2
-
sacwcicwvw(htwivofftu) = ydlrcdhdyg bsivqoador (yhkghxrazq )
-
01 May 2009
sacwcicwvw(htwivofftu) = pzjedggrip bsivqoador (yhkghxrazq )
Phase 1
36
kjzrafakdd(ivnhdcnluc) = useahtxvwf ewslkzjmqd (lpawcvapsj )
-
01 Mar 2008
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Approval

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Regulation

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