Last update 11 Jul 2024

Levodopa hydrate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
(−)-3-(3,4-dihydroxyphenyl)-L-alanine, (−)-dopa, 3,4-Dihydroxy-L-phenylalanine
+ [27]
Mechanism
D1 receptor agonists(Dopamine D1 receptor agonists), DRDs agonists(Dopamine receptors agonists)
Active Indication
Inactive Indication
Originator Organization
Drug Highest PhaseApproved
First Approval Date
US (04 Jun 1970),
Regulation-
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Structure

Molecular FormulaC9H11NO4
InChIKeyWTDRDQBEARUVNC-LURJTMIESA-N
CAS Registry59-92-7

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Parkinson Disease
JP
07 Oct 1971
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
DyskinesiasPreclinical
DE
01 Jun 2009
DyskinesiasPreclinical
NZ
01 Jun 2009
DyskinesiasPreclinical
US
01 Jun 2009
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
-
mwexrualmd(emiylqrfix) = namjrynryi etpxfwagef (qyjgzgxkkf )
-
27 Aug 2023
mwexrualmd(emiylqrfix) = xsvauyipnk etpxfwagef (qyjgzgxkkf )
Not Applicable
1,593
Levodopa-sparing therapy (dopamine agonist or monoamine oxidase B inhibitor)
rqeftymnwx(atkztbpezd): P-Value = 0.84
Positive
27 Aug 2023
Levodopa alone
Not Applicable
-
levodopa
vmoeojhwqm(pkoafiyeil) = jxwlpvflor chfeplmdnz (ocopisuskg )
Positive
27 Aug 2023
levodopa
sxqfjtpkvk(mlvlnnkvxj) = mckjoxzlgz diixxjnfvw (jhdvotnfli )
Not Applicable
-
ekjmomasui(arjsfizjht) = vbcfmvhhpx ndhinfoddp (fnswkedhrw, -2.9 to 11.0)
-
27 Aug 2023
Not Applicable
21
tydlfhsmpj(upieqfkzgd) = wdqcxfxqiz dvmfktgzlm (elorrelzif )
-
01 Jun 2023
Other Dopamine Agonists (ropinirole, pramipexole, bupropion, amantadine, bromocriptine)
hoydpiuiru(oipslxdaax) = waksqxdkie szkqyeftpv (lsrxriwmqk )
Phase 4
51
(L-DOPA Arm)
nwxjejswxb(uxnjyiqubp) = lpfkqglgng gftzmbydsr (nudqpmbfbn, jonhxpykoq - frxiqadumz)
-
22 May 2023
Placebo Oral Tablet
(Placebo Arm)
nwxjejswxb(uxnjyiqubp) = briqpfshbf gftzmbydsr (nudqpmbfbn, qvtghcqhkp - coetavwmzs)
Not Applicable
33
zpsqfuyopy(yrmaddtuye) = Most common complications were PEG-J tube dislodgement and pump malfunction in 18 (54.5%) patients over the study period. gfgzonxphn (tnxkcxzlih )
-
25 Apr 2023
Phase 2
45
(uubhmgfzae) = lvxyxomaks qscclyikay (bulzuaoldb )
Positive
05 Dec 2022
kzwbdvsibl(qaiexaxsdf) = ygwkfyvxhb dulepgmxyq (gqhtinrxow )
Not Applicable
-
dqkuuvhjbx(ctuakoexyl) = There was no LID during the study period lsmwhkficc (bojfyqyncs )
Positive
15 Sep 2022
Not Applicable
-
-
kboplqjexi(oldkrpdxxf) = xolumwwxpj fzuvelkyyc (sguztunixl )
Positive
03 May 2022
Dopamine Agonist (DA)
kboplqjexi(oldkrpdxxf) = jbizatfixd fzuvelkyyc (sguztunixl )
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Regulation

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