Last update 20 Mar 2025

SLV-334

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Target
CD10 x ECE
Action
inhibitors
Mechanism
ECE inhibitors(Endothelin-converting enzyme 1 inhibitors), enkephalinase inhibitors(Neprilysin inhibitors)
Therapeutic Areas
Nervous System DiseasesOther Diseases
Active Indication-
Inactive Indication
Brain InjuriesBrain Injuries, Traumatic
Originator Organization
AbbVie, Inc.AbbVie, Inc.
Active Organization-
Inactive Organization
Solvay Pharmaceuticals, Inc.Solvay Pharmaceuticals, Inc.Abbott Products LLCAbbVie, Inc.AbbVie, Inc.
Drug Highest PhaseDiscontinuedPhase 2
First Approval Date-
Regulation-
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Structure/Sequence

Molecular FormulaC33H36N2O6
InChIKeyLOFDNSDPZTVIIO-VPUSJEBWSA-N
CAS Registry182821-33-6

Related

2
Clinical Trials associated with SLV-334
NCT01044524
/ CompletedPhase 1
An Open Label Study to Determine ADME of 14C Labeled SLV334 and Its Metabolites After Single Intravenous Dose Infusion
NCT00735085
/ TerminatedPhase 2
A Randomized, Double Blind, Placebo-Controlled Dose Escalation Study to Investigate the Safety and Pharmacokinetics After Single and Multiple Doses of SLV334 in Sequential Cohorts of Patients With Moderate and Severe Traumatic Brain Injury
100 Clinical Results associated with SLV-334
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100 Translational Medicine associated with SLV-334
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100 Patents (Medical) associated with SLV-334
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100 Deals associated with SLV-334
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External Link

KEGGWikiATCDrug Bank
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DB15356

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Brain Injuries, TraumaticPhase 2
Spain
Abbott Products LLC
01 Apr 2009
Brain Injuries, TraumaticPhase 2
Italy
Abbott Products LLC
01 Apr 2009
Brain Injuries, TraumaticPhase 2
United States
Abbott Products LLC
01 Apr 2009
Brain Injuries, TraumaticPhase 2
Israel
Abbott Products LLC
01 Apr 2009
Brain InjuriesPhase 2-
AbbVie, Inc.AbbVie, Inc.
-
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Clinical Result

Indication
Phase
Evaluation
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Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date

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Approval

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Regulation

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